Separable Regulatory Elements Governing myogenin Transcription in Mouse Embryogenesis
Expression of the myogenic helix-loop-helix (HLH) protein myogenin in muscle cell precursors within somites and limb buds is among the earliest events associated with myogenic lineage determination in vertebrates. Mutations in the myogenin promoter that abolish binding sites for myogenic HLH protein...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1993-07, Vol.261 (5118), p.215-218 |
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| creator | Cheng, Tse-Chang Wallace, Mia C. Merlie, John P. Olson, Eric N. |
| description | Expression of the myogenic helix-loop-helix (HLH) protein myogenin in muscle cell precursors within somites and limb buds is among the earliest events associated with myogenic lineage determination in vertebrates. Mutations in the myogenin promoter that abolish binding sites for myogenic HLH proteins or myocyte enhancer factor-2 (MEF-2) suppressed transcription of a linked lacZ transgene in subsets of myogenic precursors in mouse embryos. These results suggest that myogenic HLH proteins and MEF-2 participate in separable regulatory circuits leading to myogenin transcription and provide evidence for positional regulation of myogenic regulators in the embryo. |
| doi_str_mv | 10.1126/science.8392225 |
| format | Article |
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Mutations in the myogenin promoter that abolish binding sites for myogenic HLH proteins or myocyte enhancer factor-2 (MEF-2) suppressed transcription of a linked lacZ transgene in subsets of myogenic precursors in mouse embryos. These results suggest that myogenic HLH proteins and MEF-2 participate in separable regulatory circuits leading to myogenin transcription and provide evidence for positional regulation of myogenic regulators in the embryo.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.8392225</identifier><identifier>PMID: 8392225</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Animals ; Binding Sites ; Biological and medical sciences ; Developmental genetics ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Drug regulation ; Embryo, Mammalian - metabolism ; Embryogenesis ; Embryos ; Extremities - embryology ; Female ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Genes ; Genetic mutation ; Government regulation ; Limb buds ; Male ; MEF2 Transcription Factors ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Transgenic ; Molecular and cellular biology ; Molecular genetics ; Muscle Proteins - genetics ; Muscles ; Muscles - embryology ; Muscles - metabolism ; Mutation ; Myogenesis ; Myogenic Regulatory Factors ; Myogenin ; Promoter Regions, Genetic ; Stem cells ; Trans-Activators - genetics ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transcription, Genetic ; Transgenes</subject><ispartof>Science (American Association for the Advancement of Science), 1993-07, Vol.261 (5118), p.215-218</ispartof><rights>Copyright 1993 American Association for the Advancement of Science</rights><rights>1993 INIST-CNRS</rights><rights>COPYRIGHT 1993 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c674t-3332dedecd345862eb08f162cba489e22a9a6cab960087fc2976010dcf11d0173</citedby><cites>FETCH-LOGICAL-c674t-3332dedecd345862eb08f162cba489e22a9a6cab960087fc2976010dcf11d0173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2881819$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2881819$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4821847$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8392225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Tse-Chang</creatorcontrib><creatorcontrib>Wallace, Mia C.</creatorcontrib><creatorcontrib>Merlie, John P.</creatorcontrib><creatorcontrib>Olson, Eric N.</creatorcontrib><title>Separable Regulatory Elements Governing myogenin Transcription in Mouse Embryogenesis</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Expression of the myogenic helix-loop-helix (HLH) protein myogenin in muscle cell precursors within somites and limb buds is among the earliest events associated with myogenic lineage determination in vertebrates. Mutations in the myogenin promoter that abolish binding sites for myogenic HLH proteins or myocyte enhancer factor-2 (MEF-2) suppressed transcription of a linked lacZ transgene in subsets of myogenic precursors in mouse embryos. These results suggest that myogenic HLH proteins and MEF-2 participate in separable regulatory circuits leading to myogenin transcription and provide evidence for positional regulation of myogenic regulators in the embryo.</description><subject>Animals</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Developmental genetics</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Drug regulation</subject><subject>Embryo, Mammalian - metabolism</subject><subject>Embryogenesis</subject><subject>Embryos</subject><subject>Extremities - embryology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genetic mutation</subject><subject>Government regulation</subject><subject>Limb buds</subject><subject>Male</subject><subject>MEF2 Transcription Factors</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred CBA</subject><subject>Mice, Transgenic</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Muscle Proteins - genetics</subject><subject>Muscles</subject><subject>Muscles - embryology</subject><subject>Muscles - metabolism</subject><subject>Mutation</subject><subject>Myogenesis</subject><subject>Myogenic Regulatory Factors</subject><subject>Myogenin</subject><subject>Promoter Regions, Genetic</subject><subject>Stem cells</subject><subject>Trans-Activators - genetics</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription, Genetic</subject><subject>Transgenes</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s1v0zAYB2ALgUY3OHMBKUIIcSCbPxLbOY6qlEmFSmzjajnOm8iTk3R2itb_HpdGhUkVVD7Y8vvY8scPoVcEnxNC-UUwFjoD55IVlNL8CZoQXORpQTF7iiYYM55KLPLn6DSEO4xjrWAn6GTkE3R7DSvtdekg-Q7N2umh95tk5qCFbgjJvP8JvrNdk7SbvoE4Sm687oLxdjXYvkvixNd-HSCZtaX_TSDY8AI9q7UL8HLsz9Dt59nN9Eu6WM6vppeL1HCRDSljjFZQgalYlktOocSyJpyaUmeyAEp1obnRZcExlqI2tBAcE1yZmpAKE8HO0Pvdvivf368hDKq1wYBzuoN4KiVyyfJMsP9CwjkWgvII3-5gox0o29X94LXZYnVJMioElziijwfQ9u5eu76D2sbpv3l6gMdWQWvNIf_hkY9kgIeh0esQ1NX1t6Pp8sfR9NP8WCrni388xUhN7xw0oOJvT5eP-MWOG9-H4KFWK29b7TeKYLUNtBoDrcaExhVvxp9bly1Ue_-n_m6s62C0q2M6jQ17lklKZLZNyusduwsx4fsylZJIUrBfNCYDag</recordid><startdate>19930709</startdate><enddate>19930709</enddate><creator>Cheng, Tse-Chang</creator><creator>Wallace, Mia C.</creator><creator>Merlie, John P.</creator><creator>Olson, Eric N.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19930709</creationdate><title>Separable Regulatory Elements Governing myogenin Transcription in Mouse Embryogenesis</title><author>Cheng, Tse-Chang ; Wallace, Mia C. ; Merlie, John P. ; Olson, Eric N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c674t-3332dedecd345862eb08f162cba489e22a9a6cab960087fc2976010dcf11d0173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Developmental genetics</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Drug regulation</topic><topic>Embryo, Mammalian - metabolism</topic><topic>Embryogenesis</topic><topic>Embryos</topic><topic>Extremities - embryology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genetic mutation</topic><topic>Government regulation</topic><topic>Limb buds</topic><topic>Male</topic><topic>MEF2 Transcription Factors</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred CBA</topic><topic>Mice, Transgenic</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Muscle Proteins - genetics</topic><topic>Muscles</topic><topic>Muscles - embryology</topic><topic>Muscles - metabolism</topic><topic>Mutation</topic><topic>Myogenesis</topic><topic>Myogenic Regulatory Factors</topic><topic>Myogenin</topic><topic>Promoter Regions, Genetic</topic><topic>Stem cells</topic><topic>Trans-Activators - genetics</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription, Genetic</topic><topic>Transgenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Tse-Chang</creatorcontrib><creatorcontrib>Wallace, Mia C.</creatorcontrib><creatorcontrib>Merlie, John P.</creatorcontrib><creatorcontrib>Olson, Eric N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Tse-Chang</au><au>Wallace, Mia C.</au><au>Merlie, John P.</au><au>Olson, Eric N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Separable Regulatory Elements Governing myogenin Transcription in Mouse Embryogenesis</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1993-07-09</date><risdate>1993</risdate><volume>261</volume><issue>5118</issue><spage>215</spage><epage>218</epage><pages>215-218</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Expression of the myogenic helix-loop-helix (HLH) protein myogenin in muscle cell precursors within somites and limb buds is among the earliest events associated with myogenic lineage determination in vertebrates. Mutations in the myogenin promoter that abolish binding sites for myogenic HLH proteins or myocyte enhancer factor-2 (MEF-2) suppressed transcription of a linked lacZ transgene in subsets of myogenic precursors in mouse embryos. These results suggest that myogenic HLH proteins and MEF-2 participate in separable regulatory circuits leading to myogenin transcription and provide evidence for positional regulation of myogenic regulators in the embryo.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8392225</pmid><doi>10.1126/science.8392225</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1993-07, Vol.261 (5118), p.215-218 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Animals Binding Sites Biological and medical sciences Developmental genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drug regulation Embryo, Mammalian - metabolism Embryogenesis Embryos Extremities - embryology Female Fundamental and applied biological sciences. Psychology Gene expression Genes Genetic mutation Government regulation Limb buds Male MEF2 Transcription Factors Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Transgenic Molecular and cellular biology Molecular genetics Muscle Proteins - genetics Muscles Muscles - embryology Muscles - metabolism Mutation Myogenesis Myogenic Regulatory Factors Myogenin Promoter Regions, Genetic Stem cells Trans-Activators - genetics Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Transgenes |
| title | Separable Regulatory Elements Governing myogenin Transcription in Mouse Embryogenesis |
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