Panuramine, a selective inhibitor of uptake of 5-hydroxytryptamine in the brain of the rat

The neurochemical profile of the novel inhibitor of uptake of 5-hydroxytryptamine (5-HT) panuramine (Wy 26002) has been investigated in the rat. In vitro, panuramine was found to be a potent and selective inhibitor of uptake of 5-HT with an IC 50 of 22 ± 4 nM. The IC 50 for inhibition of uptake of n...

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Veröffentlicht in:	Neuropharmacology 1984-01, Vol.23 (9), p.1049-1052
Hauptverfasser:	Blurton, P.A., Broadhurst, A.M., Cross, J.A., Ennis, C., Wood, M.D., Wyllie, M.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT receptors 5-HT release 5-HT uptake inhibition in vivo Animals Biogenic Amines - metabolism Biological and medical sciences Brain Chemistry - drug effects Corpus Striatum - metabolism Dopamine - metabolism Hypothalamus - metabolism In Vitro Techniques Medical sciences monoamine uptake inhibition Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Norepinephrine - metabolism p-chloroamphetamine p-Chloroamphetamine - pharmacology Pharmacology. Drug treatments Piperidines - pharmacology Potassium - pharmacology Rats Receptors, Dopamine - metabolism Receptors, Serotonin - drug effects Serotonin - metabolism Serotonin Antagonists - pharmacology Serotoninergic system Synaptosomes - metabolism
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