Inhibition of Furosemide-Induced Kaliuresis in the Rat by Trilostane, an Inhibitor of Adrenal Steroidogenesis

Abstract In rats treated with furosemide, urinary losses of water, sodium and potassium were accompanied by increased circulating levels of aldosterone. Trilostane, an inhibitor of adrenal 3β-hydroxysteroid dehydrogenase activity, prevented furosemide-induced hyperaldosteronism which resulted in a p...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1984-12, Vol.177 (3), p.388-391
Hauptverfasser:	Harding, Homer R., Creange, John E., Potts, Gordon O., Schane, H. Philip
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors Adrenalectomy Aldosterone - blood Animals Biological and medical sciences Dihydrotestosterone - analogs & derivatives Dihydrotestosterone - pharmacology Diuresis - drug effects Furosemide - pharmacology Male Medical sciences Natriuresis - drug effects Pharmacology. Drug treatments Potassium - urine Rats Rats, Inbred Strains Spironolactone - pharmacology Urinary system
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