CORTISOL PRODUCTION BY ALDOSTERONE-PRODUCING ADENOMAS IN VITRO

SUMMARY 1. In vitro short‐term production of cortisol by dispersed tumour and non‐tumorous adrenal cortical cells was measured with and without added angiotensin II (AII) or adrenocorticotrophin (ACTH) in adrenals removed from five patients with primary aldosteronism. 2. Aldosterone‐producing adenom...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 1993-05, Vol.20 (5), p.292-295
Hauptverfasser:	Stowasser, Michael, Tunny, Terry J., Klemm, Shelley A., Gordon, Richard D.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenoma Adenoma - metabolism adrenal cortex Adrenal Cortex - drug effects Adrenal Cortex - metabolism Adrenal Cortex Neoplasms - metabolism Adrenals. Adrenal axis. Renin-angiotensin system (diseases) adrenocorticotrophin Adrenocorticotropic Hormone - pharmacology aldosterone Aldosterone - biosynthesis aldosteronism angiotensin Angiotensin II - pharmacology Biological and medical sciences cortisol Dexamethasone Dose-Response Relationship, Drug Endocrinopathies Female Humans Hydrocortisone - biosynthesis Hydrocortisone - blood Hyperaldosteronism - metabolism in vitro In Vitro Techniques Male Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms steroid biosynthesis steroid regulation
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