Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome
The possible contribution of metabolites of arachidonic acid to the increased permeability of the alveolar-capillary barrier in the adult respiratory distress syndrome was examined by quantifying the pulmonary edema fluid concentrations of lipoxygenase and cyclooxygenase products. The concentration...
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| Veröffentlicht in: | Journal of clinical immunology 1984-11, Vol.4 (6), p.479-483 |
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| container_end_page | 483 |
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| container_issue | 6 |
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| container_title | Journal of clinical immunology |
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| creator | MATTHAY, M. A ESCHENBACHER, W. L GOETZL, E. J |
| description | The possible contribution of metabolites of arachidonic acid to the increased permeability of the alveolar-capillary barrier in the adult respiratory distress syndrome was examined by quantifying the pulmonary edema fluid concentrations of lipoxygenase and cyclooxygenase products. The concentration of leukotriene D4 in pulmonary edema fluid of 10 patients with the adult respiratory distress syndrome (18.5 +/- 6.8 pmol/ml; mean +/- SD), assessed by specific radioimmunoassay after isolation of the mediator, was significantly higher (P less than 0.001) than that of five patients with cardiogenic pulmonary edema (4.4 +/- 1.1 pmol/ml). The concentrations of leukotrienes B4 and C4, prostaglandin E2, and thromboxane B2 in edema fluid were not significantly different in the adult respiratory distress syndrome patients than in the other subjects with pulmonary edema. The edema fluid concentration of leukotriene D4 correlated with the ratio of edema fluid to plasma concentrations of albumin (r = 0.64). Leukotriene D4 thus may contribute to the permeability defect which allows an accumulation of protein-rich alveolar fluid in the adult respiratory distress syndrome. |
| doi_str_mv | 10.1007/BF00916578 |
| format | Article |
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The concentrations of leukotrienes B4 and C4, prostaglandin E2, and thromboxane B2 in edema fluid were not significantly different in the adult respiratory distress syndrome patients than in the other subjects with pulmonary edema. The edema fluid concentration of leukotriene D4 correlated with the ratio of edema fluid to plasma concentrations of albumin (r = 0.64). Leukotriene D4 thus may contribute to the permeability defect which allows an accumulation of protein-rich alveolar fluid in the adult respiratory distress syndrome.</description><identifier>ISSN: 0271-9142</identifier><identifier>EISSN: 1573-2592</identifier><identifier>DOI: 10.1007/BF00916578</identifier><identifier>PMID: 6511865</identifier><identifier>CODEN: JCIMDO</identifier><language>eng</language><publisher>New York, NY: Kluwer/Plenum</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Capillary Permeability ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Pneumology ; Pulmonary Alveoli - physiopathology ; Pulmonary Edema - complications ; Pulmonary Edema - metabolism ; Pulmonary Edema - physiopathology ; Respiratory Distress Syndrome, Adult - complications ; Respiratory Distress Syndrome, Adult - metabolism ; Respiratory Distress Syndrome, Adult - physiopathology ; Respiratory system : syndromes and miscellaneous diseases ; Serum Albumin - metabolism ; SRS-A - metabolism</subject><ispartof>Journal of clinical immunology, 1984-11, Vol.4 (6), p.479-483</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-b41eacc8ec13eb49b4421d9d1e88f58ae0ad0de884cf9ab4a775db35bc7ec6193</citedby><cites>FETCH-LOGICAL-c311t-b41eacc8ec13eb49b4421d9d1e88f58ae0ad0de884cf9ab4a775db35bc7ec6193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8989681$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6511865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MATTHAY, M. A</creatorcontrib><creatorcontrib>ESCHENBACHER, W. L</creatorcontrib><creatorcontrib>GOETZL, E. J</creatorcontrib><title>Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome</title><title>Journal of clinical immunology</title><addtitle>J Clin Immunol</addtitle><description>The possible contribution of metabolites of arachidonic acid to the increased permeability of the alveolar-capillary barrier in the adult respiratory distress syndrome was examined by quantifying the pulmonary edema fluid concentrations of lipoxygenase and cyclooxygenase products. The concentration of leukotriene D4 in pulmonary edema fluid of 10 patients with the adult respiratory distress syndrome (18.5 +/- 6.8 pmol/ml; mean +/- SD), assessed by specific radioimmunoassay after isolation of the mediator, was significantly higher (P less than 0.001) than that of five patients with cardiogenic pulmonary edema (4.4 +/- 1.1 pmol/ml). The concentrations of leukotrienes B4 and C4, prostaglandin E2, and thromboxane B2 in edema fluid were not significantly different in the adult respiratory distress syndrome patients than in the other subjects with pulmonary edema. The edema fluid concentration of leukotriene D4 correlated with the ratio of edema fluid to plasma concentrations of albumin (r = 0.64). Leukotriene D4 thus may contribute to the permeability defect which allows an accumulation of protein-rich alveolar fluid in the adult respiratory distress syndrome.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Capillary Permeability</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Pulmonary Alveoli - physiopathology</subject><subject>Pulmonary Edema - complications</subject><subject>Pulmonary Edema - metabolism</subject><subject>Pulmonary Edema - physiopathology</subject><subject>Respiratory Distress Syndrome, Adult - complications</subject><subject>Respiratory Distress Syndrome, Adult - metabolism</subject><subject>Respiratory Distress Syndrome, Adult - physiopathology</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Serum Albumin - metabolism</subject><subject>SRS-A - metabolism</subject><issn>0271-9142</issn><issn>1573-2592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtr3TAUhEVpSW8em-4LWpQuCm50bMuWlkmaFwSyadZGlo6JEllyJDkl9M9Hl1yS1WGYbwbOEPIN2G9grD8-vWBMQsd78YlsgPdNVXNZfyYbVvdQSWjrr2Q_pQfGWNPVfI_sdRxAdHxD_p87fFYZDdXBa_Q5qmyDTzRM1OH6GHK06JH-aan1dFndHLyKLxQNzopObrVmiy4lVcKJ_rP5nuZ7pMqsLtOIabGlMpSIsSkXnWh68SaGGQ_Jl0m5hEe7e0DuLs7_nl1VN7eX12cnN5VuAHI1toBKa4EaGhxbObZtDUYaQCEmLhQyZZgpotWTVGOr-p6bseGj7lF3IJsD8vOtd4nhacWUh9kmjc4pj2FNQ89F3fFmC_56A3UMKUWchiXaubw7ABu2Sw8fSxf4-651HWc07-hu2uL_2PkqaeWmqLy26R0TUshOQPMKlReI0w</recordid><startdate>198411</startdate><enddate>198411</enddate><creator>MATTHAY, M. A</creator><creator>ESCHENBACHER, W. L</creator><creator>GOETZL, E. J</creator><general>Kluwer/Plenum</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198411</creationdate><title>Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome</title><author>MATTHAY, M. A ; ESCHENBACHER, W. L ; GOETZL, E. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-b41eacc8ec13eb49b4421d9d1e88f58ae0ad0de884cf9ab4a775db35bc7ec6193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Capillary Permeability</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Pulmonary Alveoli - physiopathology</topic><topic>Pulmonary Edema - complications</topic><topic>Pulmonary Edema - metabolism</topic><topic>Pulmonary Edema - physiopathology</topic><topic>Respiratory Distress Syndrome, Adult - complications</topic><topic>Respiratory Distress Syndrome, Adult - metabolism</topic><topic>Respiratory Distress Syndrome, Adult - physiopathology</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Serum Albumin - metabolism</topic><topic>SRS-A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MATTHAY, M. A</creatorcontrib><creatorcontrib>ESCHENBACHER, W. L</creatorcontrib><creatorcontrib>GOETZL, E. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MATTHAY, M. A</au><au>ESCHENBACHER, W. L</au><au>GOETZL, E. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome</atitle><jtitle>Journal of clinical immunology</jtitle><addtitle>J Clin Immunol</addtitle><date>1984-11</date><risdate>1984</risdate><volume>4</volume><issue>6</issue><spage>479</spage><epage>483</epage><pages>479-483</pages><issn>0271-9142</issn><eissn>1573-2592</eissn><coden>JCIMDO</coden><abstract>The possible contribution of metabolites of arachidonic acid to the increased permeability of the alveolar-capillary barrier in the adult respiratory distress syndrome was examined by quantifying the pulmonary edema fluid concentrations of lipoxygenase and cyclooxygenase products. The concentration of leukotriene D4 in pulmonary edema fluid of 10 patients with the adult respiratory distress syndrome (18.5 +/- 6.8 pmol/ml; mean +/- SD), assessed by specific radioimmunoassay after isolation of the mediator, was significantly higher (P less than 0.001) than that of five patients with cardiogenic pulmonary edema (4.4 +/- 1.1 pmol/ml). The concentrations of leukotrienes B4 and C4, prostaglandin E2, and thromboxane B2 in edema fluid were not significantly different in the adult respiratory distress syndrome patients than in the other subjects with pulmonary edema. The edema fluid concentration of leukotriene D4 correlated with the ratio of edema fluid to plasma concentrations of albumin (r = 0.64). Leukotriene D4 thus may contribute to the permeability defect which allows an accumulation of protein-rich alveolar fluid in the adult respiratory distress syndrome.</abstract><cop>New York, NY</cop><pub>Kluwer/Plenum</pub><pmid>6511865</pmid><doi>10.1007/BF00916578</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of clinical immunology, 1984-11, Vol.4 (6), p.479-483 |
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| language | eng |
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| subjects | Adolescent Adult Aged Biological and medical sciences Capillary Permeability Female Humans Male Medical sciences Middle Aged Pneumology Pulmonary Alveoli - physiopathology Pulmonary Edema - complications Pulmonary Edema - metabolism Pulmonary Edema - physiopathology Respiratory Distress Syndrome, Adult - complications Respiratory Distress Syndrome, Adult - metabolism Respiratory Distress Syndrome, Adult - physiopathology Respiratory system : syndromes and miscellaneous diseases Serum Albumin - metabolism SRS-A - metabolism |
| title | Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome |
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