Combined intracerebral microdialysis and electrophysiological recording: methodology and applications
A microdialysis probe is described that can simultaneously monitor indices of electrical activity, ionic homeostasis and changes in the composition of the extracellular fluid at the same brain site in anaesthetised laboratory animals. The probe is no larger than its conventional counterpart and avoi...
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| Veröffentlicht in: | Journal of neuroscience methods 1993-04, Vol.47 (1), p.139-145 |
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| container_title | Journal of neuroscience methods |
| container_volume | 47 |
| creator | Obrenovitch, T.P. Richards, D.A. Sarna, G.S. Symon, L. |
| description | A microdialysis probe is described that can simultaneously monitor indices of electrical activity, ionic homeostasis and changes in the composition of the extracellular fluid at the same brain site in anaesthetised laboratory animals. The probe is no larger than its conventional counterpart and avoids tissue injury problems due to implantation of separate recording electrodes. Examples are given of its application to the study of changes following probe implantation, cerebral ischaemia and local high K
+-induced depolarisation. |
| doi_str_mv | 10.1016/0165-0270(93)90030-U |
| format | Article |
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+-induced depolarisation.</description><subject>Action Potentials - drug effects</subject><subject>Anesthesia, General</subject><subject>Animals</subject><subject>Anoxic depolarisation</subject><subject>Biological and medical sciences</subject><subject>Brain - physiology</subject><subject>Brain Chemistry</subject><subject>Calcium - physiology</subject><subject>Cerebral ischaemia</subject><subject>DC potential</subject><subject>Dialysis - methods</subject><subject>Electroencephalogram</subject><subject>Electroencephalography - instrumentation</subject><subject>Electroencephalography - methods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects. Models. 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Methods</topic><topic>Glutamates - analysis</topic><topic>Glutamic Acid</topic><topic>Male</topic><topic>Microchemistry - methods</topic><topic>Microdialysis</topic><topic>Microelectrodes</topic><topic>Potassium - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Spreading depression</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obrenovitch, T.P.</creatorcontrib><creatorcontrib>Richards, D.A.</creatorcontrib><creatorcontrib>Sarna, G.S.</creatorcontrib><creatorcontrib>Symon, L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroscience methods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obrenovitch, T.P.</au><au>Richards, D.A.</au><au>Sarna, G.S.</au><au>Symon, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined intracerebral microdialysis and electrophysiological recording: methodology and applications</atitle><jtitle>Journal of neuroscience methods</jtitle><addtitle>J Neurosci Methods</addtitle><date>1993-04-01</date><risdate>1993</risdate><volume>47</volume><issue>1</issue><spage>139</spage><epage>145</epage><pages>139-145</pages><issn>0165-0270</issn><eissn>1872-678X</eissn><coden>JNMEDT</coden><abstract>A microdialysis probe is described that can simultaneously monitor indices of electrical activity, ionic homeostasis and changes in the composition of the extracellular fluid at the same brain site in anaesthetised laboratory animals. The probe is no larger than its conventional counterpart and avoids tissue injury problems due to implantation of separate recording electrodes. Examples are given of its application to the study of changes following probe implantation, cerebral ischaemia and local high K
+-induced depolarisation.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>8100599</pmid><doi>10.1016/0165-0270(93)90030-U</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-0270 |
| ispartof | Journal of neuroscience methods, 1993-04, Vol.47 (1), p.139-145 |
| issn | 0165-0270 1872-678X |
| language | eng |
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| source | MEDLINE; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Action Potentials - drug effects Anesthesia, General Animals Anoxic depolarisation Biological and medical sciences Brain - physiology Brain Chemistry Calcium - physiology Cerebral ischaemia DC potential Dialysis - methods Electroencephalogram Electroencephalography - instrumentation Electroencephalography - methods Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Glutamates - analysis Glutamic Acid Male Microchemistry - methods Microdialysis Microelectrodes Potassium - pharmacology Rats Rats, Sprague-Dawley Spreading depression Vertebrates: nervous system and sense organs |
| title | Combined intracerebral microdialysis and electrophysiological recording: methodology and applications |
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