Anthropometric measurements in the second trimester fetus
Normal anthropometric measurements, of accepted value for clinicians and pathologists in the assessment of the dysmorphic neonate, have not in the past been available for the second trimester fetus, in which dysmorphic features are often more subtle and objective measurements most needed. In order t...
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Veröffentlicht in: | Early human development 1993-04, Vol.33 (1), p.45-59 |
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description | Normal anthropometric measurements, of accepted value for clinicians and pathologists in the assessment of the dysmorphic neonate, have not in the past been available for the second trimester fetus, in which dysmorphic features are often more subtle and objective measurements most needed. In order to establish these values 19 anthropometric measurements, comparable to those published for the larger fetus and neonate, were recorded at autopsy on each of 260 overtly normal non-macerated singleton fetuses between 13 and 26 weeks gestation. Regression lines for each parameter, and growth ratios of potential value for description and assessment of dysmorphic features, were derived. The sex ratio was 1.27 and as there was no statistically significant sex difference for any of the 19 measurements chosen, the data was subsequently pooled. There were linear correlations between gestational age and each growth parameter, all but three exceeding 0.90. The linear correlations between pairs of growth parameter were higher than the correlations between gestational age and individual growth parameters. This suggests that growth parameter pairs, expressed as a ratio, are less affected by errors in gestational age estimation. Ratios enabling the dysmorphologist to more objectively assess common observations such as abnormalities of head shape, relationship between limb and trunk length and gross proportional relationships between major body segments were derived. Collected measurements were compared with established ultrasound reference ranges. While reference ranges for biparietal diameter and head circumference showed close concordance with those derived from ultrasound measurements, the abdominal circumference was consistently lower than that measured by ultrasound possibly because of differing trunk positions in utero compared with after death. The graphs and ratios derived in this study can be rapidly applied to confirm visual impressions at clinical examination and at autopsy. |
doi_str_mv | 10.1016/0378-3782(93)90172-Q |
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In order to establish these values 19 anthropometric measurements, comparable to those published for the larger fetus and neonate, were recorded at autopsy on each of 260 overtly normal non-macerated singleton fetuses between 13 and 26 weeks gestation. Regression lines for each parameter, and growth ratios of potential value for description and assessment of dysmorphic features, were derived. The sex ratio was 1.27 and as there was no statistically significant sex difference for any of the 19 measurements chosen, the data was subsequently pooled. There were linear correlations between gestational age and each growth parameter, all but three exceeding 0.90. The linear correlations between pairs of growth parameter were higher than the correlations between gestational age and individual growth parameters. This suggests that growth parameter pairs, expressed as a ratio, are less affected by errors in gestational age estimation. Ratios enabling the dysmorphologist to more objectively assess common observations such as abnormalities of head shape, relationship between limb and trunk length and gross proportional relationships between major body segments were derived. Collected measurements were compared with established ultrasound reference ranges. While reference ranges for biparietal diameter and head circumference showed close concordance with those derived from ultrasound measurements, the abdominal circumference was consistently lower than that measured by ultrasound possibly because of differing trunk positions in utero compared with after death. The graphs and ratios derived in this study can be rapidly applied to confirm visual impressions at clinical examination and at autopsy.</description><identifier>ISSN: 0378-3782</identifier><identifier>EISSN: 1872-6232</identifier><identifier>DOI: 10.1016/0378-3782(93)90172-Q</identifier><identifier>PMID: 8319554</identifier><identifier>CODEN: EHDEDN</identifier><language>eng</language><publisher>Lausanne: Elsevier Ireland Ltd</publisher><subject>anthropometric measurements ; Anthropometry ; Biological and medical sciences ; Embryology: invertebrates and vertebrates. Teratology ; Embryonic and Fetal Development ; Female ; fetal biometric parameters ; Fetus - anatomy & histology ; Fundamental and applied biological sciences. Psychology ; Gestational Age ; human fetus ; Humans ; Male ; Organogenesis. Fetal development ; Organogenesis. 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In order to establish these values 19 anthropometric measurements, comparable to those published for the larger fetus and neonate, were recorded at autopsy on each of 260 overtly normal non-macerated singleton fetuses between 13 and 26 weeks gestation. Regression lines for each parameter, and growth ratios of potential value for description and assessment of dysmorphic features, were derived. The sex ratio was 1.27 and as there was no statistically significant sex difference for any of the 19 measurements chosen, the data was subsequently pooled. There were linear correlations between gestational age and each growth parameter, all but three exceeding 0.90. The linear correlations between pairs of growth parameter were higher than the correlations between gestational age and individual growth parameters. This suggests that growth parameter pairs, expressed as a ratio, are less affected by errors in gestational age estimation. Ratios enabling the dysmorphologist to more objectively assess common observations such as abnormalities of head shape, relationship between limb and trunk length and gross proportional relationships between major body segments were derived. Collected measurements were compared with established ultrasound reference ranges. While reference ranges for biparietal diameter and head circumference showed close concordance with those derived from ultrasound measurements, the abdominal circumference was consistently lower than that measured by ultrasound possibly because of differing trunk positions in utero compared with after death. The graphs and ratios derived in this study can be rapidly applied to confirm visual impressions at clinical examination and at autopsy.</description><subject>anthropometric measurements</subject><subject>Anthropometry</subject><subject>Biological and medical sciences</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Embryonic and Fetal Development</subject><subject>Female</subject><subject>fetal biometric parameters</subject><subject>Fetus - anatomy & histology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gestational Age</subject><subject>human fetus</subject><subject>Humans</subject><subject>Male</subject><subject>Organogenesis. Fetal development</subject><subject>Organogenesis. Physiological fonctions</subject><subject>perinatal autopsy</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><subject>Sex Ratio</subject><issn>0378-3782</issn><issn>1872-6232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMo67r6DRR6ENFDNWmaNL0Iy-I_WJAFPYc0mWBk265JKvjtzbpljx6GDLw3My8_hM4JviWY8DtMK5GnKq5relNjUhX56gBNiUgNL2hxiKZ7yzE6CeETY8xEjSdoIiipGSunqJ538cP3m76F6J3OWlBh8NBCF0Pmuix-QBZA953Jkt5CiOAzC3EIp-jIqnWAs_GdoffHh7fFc758fXpZzJe5poLH3ECREhHBecO5oaZQilgmhLGWKcAcUhQDytpGV41QphEcrKlKJlRZ1pWmM3S127vx_deQAsjWBQ3rteqgH4KsmEgX0odnqNwZte9D8GDlJiVW_kcSLLfE5BaH3OKQNZV_xOQqjV2M-4emBbMfGhEl_XLUVdBqbb3qtAt7W1kxImqRbPc7GyQW3w68DNpBp8E4DzpK07v_c_wCFgaIlQ</recordid><startdate>19930401</startdate><enddate>19930401</enddate><creator>Chambers, Helen M.</creator><creator>Knowles, Simon</creator><creator>Staples, Alan</creator><creator>Tamblyn, Michelle</creator><creator>Haan, Eric A.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930401</creationdate><title>Anthropometric measurements in the second trimester fetus</title><author>Chambers, Helen M. ; Knowles, Simon ; Staples, Alan ; Tamblyn, Michelle ; Haan, Eric A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-de21871866b66d3d2aa1f588dff5ae06e831deaffbc7b8adb86efd7458a4497c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>anthropometric measurements</topic><topic>Anthropometry</topic><topic>Biological and medical sciences</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryonic and Fetal Development</topic><topic>Female</topic><topic>fetal biometric parameters</topic><topic>Fetus - anatomy & histology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gestational Age</topic><topic>human fetus</topic><topic>Humans</topic><topic>Male</topic><topic>Organogenesis. Fetal development</topic><topic>Organogenesis. Physiological fonctions</topic><topic>perinatal autopsy</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><topic>Sex Ratio</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chambers, Helen M.</creatorcontrib><creatorcontrib>Knowles, Simon</creatorcontrib><creatorcontrib>Staples, Alan</creatorcontrib><creatorcontrib>Tamblyn, Michelle</creatorcontrib><creatorcontrib>Haan, Eric A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Early human development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chambers, Helen M.</au><au>Knowles, Simon</au><au>Staples, Alan</au><au>Tamblyn, Michelle</au><au>Haan, Eric A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anthropometric measurements in the second trimester fetus</atitle><jtitle>Early human development</jtitle><addtitle>Early Hum Dev</addtitle><date>1993-04-01</date><risdate>1993</risdate><volume>33</volume><issue>1</issue><spage>45</spage><epage>59</epage><pages>45-59</pages><issn>0378-3782</issn><eissn>1872-6232</eissn><coden>EHDEDN</coden><abstract>Normal anthropometric measurements, of accepted value for clinicians and pathologists in the assessment of the dysmorphic neonate, have not in the past been available for the second trimester fetus, in which dysmorphic features are often more subtle and objective measurements most needed. In order to establish these values 19 anthropometric measurements, comparable to those published for the larger fetus and neonate, were recorded at autopsy on each of 260 overtly normal non-macerated singleton fetuses between 13 and 26 weeks gestation. Regression lines for each parameter, and growth ratios of potential value for description and assessment of dysmorphic features, were derived. The sex ratio was 1.27 and as there was no statistically significant sex difference for any of the 19 measurements chosen, the data was subsequently pooled. There were linear correlations between gestational age and each growth parameter, all but three exceeding 0.90. The linear correlations between pairs of growth parameter were higher than the correlations between gestational age and individual growth parameters. This suggests that growth parameter pairs, expressed as a ratio, are less affected by errors in gestational age estimation. Ratios enabling the dysmorphologist to more objectively assess common observations such as abnormalities of head shape, relationship between limb and trunk length and gross proportional relationships between major body segments were derived. Collected measurements were compared with established ultrasound reference ranges. While reference ranges for biparietal diameter and head circumference showed close concordance with those derived from ultrasound measurements, the abdominal circumference was consistently lower than that measured by ultrasound possibly because of differing trunk positions in utero compared with after death. The graphs and ratios derived in this study can be rapidly applied to confirm visual impressions at clinical examination and at autopsy.</abstract><cop>Lausanne</cop><cop>New York,NY</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>8319554</pmid><doi>10.1016/0378-3782(93)90172-Q</doi><tpages>15</tpages></addata></record> |
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subjects | anthropometric measurements Anthropometry Biological and medical sciences Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development Female fetal biometric parameters Fetus - anatomy & histology Fundamental and applied biological sciences. Psychology Gestational Age human fetus Humans Male Organogenesis. Fetal development Organogenesis. Physiological fonctions perinatal autopsy Reference Values Regression Analysis Sex Ratio |
title | Anthropometric measurements in the second trimester fetus |
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