Biochemical evidence for peripheral neural regulation of adrenocortical regeneration in response to bilateral adrenal enucleation
Male sprague-Dawley rats (130–150 g) with bilateral adrenal enucleation were used in this study. Animals were sacrificed at 2, 7, and 11 days post enucleation and plasma corticosterone and adrenal gland acetylcholin-esterase (AChE), choline acetyltransferase (ChAT), corticosterone, epinephrine (EP)...
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| Veröffentlicht in: | Life sciences (1973) 1993, Vol.53 (3), p.275-282 |
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| creator | Gragg, Richard D. Soliman, Karam F.A. |
| description | Male sprague-Dawley rats (130–150 g) with bilateral adrenal enucleation were used in this study. Animals were sacrificed at 2, 7, and 11 days post enucleation and plasma corticosterone and adrenal gland acetylcholin-esterase (AChE), choline acetyltransferase (ChAT), corticosterone, epinephrine (EP) and norepinephrine (NE) were assayed. The results show a progressive and gradual increase in plasma and adrenal corticosterone levels, AChE, ChAT, EP, and NE levels in the regenerating adrenal cortex from day 2 to day 11 post bilateral adrenal enucleation. At day 11 post surgery, the activities of ChAT and AChE were 60% and 25%, respectively when compared to sham operated control. The EP and NE levels returned to normal levels after 11 days post surgery in the regenerating gland when compared to the sham control. The presence of both cholinergic enzymes and the availability of high levels of catecholamine strongly suggest a progressive development of sympathetic innervation in the regenerating adrenal cortex. |
| doi_str_mv | 10.1016/0024-3205(93)90679-W |
| format | Article |
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Animals were sacrificed at 2, 7, and 11 days post enucleation and plasma corticosterone and adrenal gland acetylcholin-esterase (AChE), choline acetyltransferase (ChAT), corticosterone, epinephrine (EP) and norepinephrine (NE) were assayed. The results show a progressive and gradual increase in plasma and adrenal corticosterone levels, AChE, ChAT, EP, and NE levels in the regenerating adrenal cortex from day 2 to day 11 post bilateral adrenal enucleation. At day 11 post surgery, the activities of ChAT and AChE were 60% and 25%, respectively when compared to sham operated control. The EP and NE levels returned to normal levels after 11 days post surgery in the regenerating gland when compared to the sham control. The presence of both cholinergic enzymes and the availability of high levels of catecholamine strongly suggest a progressive development of sympathetic innervation in the regenerating adrenal cortex.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(93)90679-W</identifier><identifier>PMID: 8321088</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Acetylcholinesterase - metabolism ; Adrenal Cortex - innervation ; Adrenal Cortex - metabolism ; Adrenal Cortex - physiology ; Adrenal Cortex - surgery ; Adrenals. Interrenals ; Animals ; Biological and medical sciences ; Choline O-Acetyltransferase - metabolism ; Corticosterone - blood ; Corticosterone - metabolism ; Epinephrine - metabolism ; Fundamental and applied biological sciences. Psychology ; Male ; Morphology. Functional localizations ; Norepinephrine - metabolism ; Peripheral Nerves - metabolism ; Peripheral Nerves - physiology ; Rats ; Rats, Sprague-Dawley ; Regeneration - physiology ; Vertebrates: endocrinology</subject><ispartof>Life sciences (1973), 1993, Vol.53 (3), p.275-282</ispartof><rights>1993</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-896a52a7f0d7510a252340f8047e9dda2ff0937fcd0e238b6e3bc726d2ab4d093</citedby><cites>FETCH-LOGICAL-c417t-896a52a7f0d7510a252340f8047e9dda2ff0937fcd0e238b6e3bc726d2ab4d093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(93)90679-W$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3772022$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8321088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gragg, Richard D.</creatorcontrib><creatorcontrib>Soliman, Karam F.A.</creatorcontrib><title>Biochemical evidence for peripheral neural regulation of adrenocortical regeneration in response to bilateral adrenal enucleation</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Male sprague-Dawley rats (130–150 g) with bilateral adrenal enucleation were used in this study. Animals were sacrificed at 2, 7, and 11 days post enucleation and plasma corticosterone and adrenal gland acetylcholin-esterase (AChE), choline acetyltransferase (ChAT), corticosterone, epinephrine (EP) and norepinephrine (NE) were assayed. The results show a progressive and gradual increase in plasma and adrenal corticosterone levels, AChE, ChAT, EP, and NE levels in the regenerating adrenal cortex from day 2 to day 11 post bilateral adrenal enucleation. At day 11 post surgery, the activities of ChAT and AChE were 60% and 25%, respectively when compared to sham operated control. The EP and NE levels returned to normal levels after 11 days post surgery in the regenerating gland when compared to the sham control. The presence of both cholinergic enzymes and the availability of high levels of catecholamine strongly suggest a progressive development of sympathetic innervation in the regenerating adrenal cortex.</description><subject>Acetylcholinesterase - metabolism</subject><subject>Adrenal Cortex - innervation</subject><subject>Adrenal Cortex - metabolism</subject><subject>Adrenal Cortex - physiology</subject><subject>Adrenal Cortex - surgery</subject><subject>Adrenals. Interrenals</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Choline O-Acetyltransferase - metabolism</subject><subject>Corticosterone - blood</subject><subject>Corticosterone - metabolism</subject><subject>Epinephrine - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Morphology. Functional localizations</subject><subject>Norepinephrine - metabolism</subject><subject>Peripheral Nerves - metabolism</subject><subject>Peripheral Nerves - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Regeneration - physiology</subject><subject>Vertebrates: endocrinology</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS1EVZbCPwApB4TgEBjbSexckKCCglSJC6hHy7HH1ChrBzupxLH_HCe72iM9je33vRnrDSEvKLyjQLv3AKypOYP2Tc_f9tCJvr55RHZUlgN0nD4muxPyhDzN-TcAtK3g5-RcckZByh25_-SjucW9N3qs8M5bDAYrF1M1YfLTLabyHnBZS8Jfy6hnH0MVXaVtwhBNTPPmLSKGQm-yD-WepxgyVnOsBl9sW6fNtE4Kixlxg5-RM6fHjM-P9YL8_PL5x-XX-vr71bfLj9e1aaiYa9l3umVaOLCipaBZy3gDTkIjsLdWM-eg58IZC8i4HDrkgxGss0wPjS3SBXl96Dul-GfBPKu9zwbHUQeMS1ailaxg3YMg7WQPIFkBmwNoUsw5oVNT8nud_ioKal2RWvNXa_6q52pbkboptpfH_suwR3syHXdS9FdHXeeSrEs6GJ9PGBeCAVunfzhgWEK785hUNn7dnvUJzaxs9P__xz9Vrq_a</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Gragg, Richard D.</creator><creator>Soliman, Karam F.A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Biochemical evidence for peripheral neural regulation of adrenocortical regeneration in response to bilateral adrenal enucleation</title><author>Gragg, Richard D. ; Soliman, Karam F.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-896a52a7f0d7510a252340f8047e9dda2ff0937fcd0e238b6e3bc726d2ab4d093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Acetylcholinesterase - metabolism</topic><topic>Adrenal Cortex - innervation</topic><topic>Adrenal Cortex - metabolism</topic><topic>Adrenal Cortex - physiology</topic><topic>Adrenal Cortex - surgery</topic><topic>Adrenals. Interrenals</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Choline O-Acetyltransferase - metabolism</topic><topic>Corticosterone - blood</topic><topic>Corticosterone - metabolism</topic><topic>Epinephrine - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Morphology. Functional localizations</topic><topic>Norepinephrine - metabolism</topic><topic>Peripheral Nerves - metabolism</topic><topic>Peripheral Nerves - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Regeneration - physiology</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gragg, Richard D.</creatorcontrib><creatorcontrib>Soliman, Karam F.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gragg, Richard D.</au><au>Soliman, Karam F.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biochemical evidence for peripheral neural regulation of adrenocortical regeneration in response to bilateral adrenal enucleation</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1993</date><risdate>1993</risdate><volume>53</volume><issue>3</issue><spage>275</spage><epage>282</epage><pages>275-282</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>Male sprague-Dawley rats (130–150 g) with bilateral adrenal enucleation were used in this study. Animals were sacrificed at 2, 7, and 11 days post enucleation and plasma corticosterone and adrenal gland acetylcholin-esterase (AChE), choline acetyltransferase (ChAT), corticosterone, epinephrine (EP) and norepinephrine (NE) were assayed. The results show a progressive and gradual increase in plasma and adrenal corticosterone levels, AChE, ChAT, EP, and NE levels in the regenerating adrenal cortex from day 2 to day 11 post bilateral adrenal enucleation. At day 11 post surgery, the activities of ChAT and AChE were 60% and 25%, respectively when compared to sham operated control. The EP and NE levels returned to normal levels after 11 days post surgery in the regenerating gland when compared to the sham control. The presence of both cholinergic enzymes and the availability of high levels of catecholamine strongly suggest a progressive development of sympathetic innervation in the regenerating adrenal cortex.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>8321088</pmid><doi>10.1016/0024-3205(93)90679-W</doi><tpages>8</tpages></addata></record> |
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| ispartof | Life sciences (1973), 1993, Vol.53 (3), p.275-282 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acetylcholinesterase - metabolism Adrenal Cortex - innervation Adrenal Cortex - metabolism Adrenal Cortex - physiology Adrenal Cortex - surgery Adrenals. Interrenals Animals Biological and medical sciences Choline O-Acetyltransferase - metabolism Corticosterone - blood Corticosterone - metabolism Epinephrine - metabolism Fundamental and applied biological sciences. Psychology Male Morphology. Functional localizations Norepinephrine - metabolism Peripheral Nerves - metabolism Peripheral Nerves - physiology Rats Rats, Sprague-Dawley Regeneration - physiology Vertebrates: endocrinology |
| title | Biochemical evidence for peripheral neural regulation of adrenocortical regeneration in response to bilateral adrenal enucleation |
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