Lack of correlation between serum cholesterol levels, lymphocyte plasma membrane fluidity and mitogen responsiveness in young and aged chickens
Chickens were studied in an attempt to demonstrate correlations between serum lipid levels and peripheral blood lymphocyte (PBL) plasma membrane fluidity and mitogen responsiveness: (a) in the laying hen; (b) during aging; and (c) following dietary manipulation of serum cholesterol of young and aged...
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| Veröffentlicht in: | Mechanisms of ageing and development 1984-01, Vol.28 (1), p.123-138 |
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| creator | Traill, Karine N. Ratheiser, Klaus Dietrich, Hermann Sailer, Sigurd Zevenbergen, Johannes L. Wick, Georg |
| description | Chickens were studied in an attempt to demonstrate correlations between serum lipid levels and peripheral blood lymphocyte (PBL) plasma membrane fluidity and mitogen responsiveness: (a) in the laying hen; (b) during aging; and (c) following dietary manipulation of serum cholesterol of young and aged chickens.
The membrane fluidity of PLB from laying hens was significantly greater than that of immature birds. However, no direct correlation was found between serum lipid levels. nor the serum free cholesterol/phospholipid (PC/PL) more composition and PBL membrane fluidity in any of the age-groups tested. Likewise, no correlation was found either between serum PC/PI mole ratio or membrane fluidity and mitogen responsiveness of PBL from birds up to 5 years of age nor was there any evidence for a decline in mitogen responsiveness up to this age. Supplementation of diets with 1% cholesterol induced hypercholesterolemia, mainly in the very low density lipoprotein (VLDL) fraction, but membrane fluidity and mitogen responsiveness remained unaffected. |
| doi_str_mv | 10.1016/0047-6374(84)90158-1 |
| format | Article |
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The membrane fluidity of PLB from laying hens was significantly greater than that of immature birds. However, no direct correlation was found between serum lipid levels. nor the serum free cholesterol/phospholipid (PC/PL) more composition and PBL membrane fluidity in any of the age-groups tested. Likewise, no correlation was found either between serum PC/PI mole ratio or membrane fluidity and mitogen responsiveness of PBL from birds up to 5 years of age nor was there any evidence for a decline in mitogen responsiveness up to this age. Supplementation of diets with 1% cholesterol induced hypercholesterolemia, mainly in the very low density lipoprotein (VLDL) fraction, but membrane fluidity and mitogen responsiveness remained unaffected.</description><identifier>ISSN: 0047-6374</identifier><identifier>EISSN: 1872-6216</identifier><identifier>DOI: 10.1016/0047-6374(84)90158-1</identifier><identifier>PMID: 6513612</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Age ; Aging ; Animals ; Cell Membrane - physiology ; chickens ; Chickens - immunology ; Chickens - physiology ; Cholesterol ; Cholesterol - blood ; Cholesterol - pharmacology ; Female ; Lipids ; Lipids - blood ; Lipoproteins - blood ; lymphocytes ; Lymphocytes - drug effects ; Lymphocytes - physiology ; Membrane Fluidity ; Mitogen response ; mitogens ; Mitogens - pharmacology ; plasma membranes</subject><ispartof>Mechanisms of ageing and development, 1984-01, Vol.28 (1), p.123-138</ispartof><rights>1984</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-d99fc9086e0be2dbcc51e33deff954b4e9e436866f4eee0a4d8fc5ada8514bc73</citedby><cites>FETCH-LOGICAL-c388t-d99fc9086e0be2dbcc51e33deff954b4e9e436866f4eee0a4d8fc5ada8514bc73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0047-6374(84)90158-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6513612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Traill, Karine N.</creatorcontrib><creatorcontrib>Ratheiser, Klaus</creatorcontrib><creatorcontrib>Dietrich, Hermann</creatorcontrib><creatorcontrib>Sailer, Sigurd</creatorcontrib><creatorcontrib>Zevenbergen, Johannes L.</creatorcontrib><creatorcontrib>Wick, Georg</creatorcontrib><title>Lack of correlation between serum cholesterol levels, lymphocyte plasma membrane fluidity and mitogen responsiveness in young and aged chickens</title><title>Mechanisms of ageing and development</title><addtitle>Mech Ageing Dev</addtitle><description>Chickens were studied in an attempt to demonstrate correlations between serum lipid levels and peripheral blood lymphocyte (PBL) plasma membrane fluidity and mitogen responsiveness: (a) in the laying hen; (b) during aging; and (c) following dietary manipulation of serum cholesterol of young and aged chickens.
The membrane fluidity of PLB from laying hens was significantly greater than that of immature birds. However, no direct correlation was found between serum lipid levels. nor the serum free cholesterol/phospholipid (PC/PL) more composition and PBL membrane fluidity in any of the age-groups tested. Likewise, no correlation was found either between serum PC/PI mole ratio or membrane fluidity and mitogen responsiveness of PBL from birds up to 5 years of age nor was there any evidence for a decline in mitogen responsiveness up to this age. Supplementation of diets with 1% cholesterol induced hypercholesterolemia, mainly in the very low density lipoprotein (VLDL) fraction, but membrane fluidity and mitogen responsiveness remained unaffected.</description><subject>Age</subject><subject>Aging</subject><subject>Animals</subject><subject>Cell Membrane - physiology</subject><subject>chickens</subject><subject>Chickens - immunology</subject><subject>Chickens - physiology</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cholesterol - pharmacology</subject><subject>Female</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Lipoproteins - blood</subject><subject>lymphocytes</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - physiology</subject><subject>Membrane Fluidity</subject><subject>Mitogen response</subject><subject>mitogens</subject><subject>Mitogens - pharmacology</subject><subject>plasma membranes</subject><issn>0047-6374</issn><issn>1872-6216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS1EVaaFNwDJK1QkAnZiO84GCVUUkEZiA2vLsW-mpv4JdjIoT9FXbqYz6hJWd3HPOVf3fAi9puQDJVR8JIS1lWhadiXZu45QLiv6DG2obOtK1FQ8R5snyQt0UcpvQghltThH54LTRtB6g-632tzhNGCTcgavJ5ci7mH6CxBxgTwHbG6ThzJBTh572IMv77FfwnibzDIBHr0uQeMAoc86Ah787KybFqyjxcFNabcmZShjisXtIUIp2EW8pDnuHjV6B3Y94swdxPISnQ3aF3h1mpfo182Xn9ffqu2Pr9-vP28r00g5VbbrBtMRKYD0UNveGE6haSwMQ8dZz6AD1ggpxMAAgGhm5WC4tlpyynrTNpfo7TF3zOnPvL6ngisGvF9fSHNRLZf1Wlf9X-FaKG84PSSyo9DkVEqGQY3ZBZ0XRYk6AFMHGupAQ0mmHoEputrenPLnPoB9Mp0IrftPx_3aO-wdZFWMg2jAugxmUja5fx94AMynqV0</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Traill, Karine N.</creator><creator>Ratheiser, Klaus</creator><creator>Dietrich, Hermann</creator><creator>Sailer, Sigurd</creator><creator>Zevenbergen, Johannes L.</creator><creator>Wick, Georg</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>Lack of correlation between serum cholesterol levels, lymphocyte plasma membrane fluidity and mitogen responsiveness in young and aged chickens</title><author>Traill, Karine N. ; Ratheiser, Klaus ; Dietrich, Hermann ; Sailer, Sigurd ; Zevenbergen, Johannes L. ; Wick, Georg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-d99fc9086e0be2dbcc51e33deff954b4e9e436866f4eee0a4d8fc5ada8514bc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Age</topic><topic>Aging</topic><topic>Animals</topic><topic>Cell Membrane - physiology</topic><topic>chickens</topic><topic>Chickens - immunology</topic><topic>Chickens - physiology</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cholesterol - pharmacology</topic><topic>Female</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Lipoproteins - blood</topic><topic>lymphocytes</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - physiology</topic><topic>Membrane Fluidity</topic><topic>Mitogen response</topic><topic>mitogens</topic><topic>Mitogens - pharmacology</topic><topic>plasma membranes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Traill, Karine N.</creatorcontrib><creatorcontrib>Ratheiser, Klaus</creatorcontrib><creatorcontrib>Dietrich, Hermann</creatorcontrib><creatorcontrib>Sailer, Sigurd</creatorcontrib><creatorcontrib>Zevenbergen, Johannes L.</creatorcontrib><creatorcontrib>Wick, Georg</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of ageing and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Traill, Karine N.</au><au>Ratheiser, Klaus</au><au>Dietrich, Hermann</au><au>Sailer, Sigurd</au><au>Zevenbergen, Johannes L.</au><au>Wick, Georg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of correlation between serum cholesterol levels, lymphocyte plasma membrane fluidity and mitogen responsiveness in young and aged chickens</atitle><jtitle>Mechanisms of ageing and development</jtitle><addtitle>Mech Ageing Dev</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>28</volume><issue>1</issue><spage>123</spage><epage>138</epage><pages>123-138</pages><issn>0047-6374</issn><eissn>1872-6216</eissn><abstract>Chickens were studied in an attempt to demonstrate correlations between serum lipid levels and peripheral blood lymphocyte (PBL) plasma membrane fluidity and mitogen responsiveness: (a) in the laying hen; (b) during aging; and (c) following dietary manipulation of serum cholesterol of young and aged chickens.
The membrane fluidity of PLB from laying hens was significantly greater than that of immature birds. However, no direct correlation was found between serum lipid levels. nor the serum free cholesterol/phospholipid (PC/PL) more composition and PBL membrane fluidity in any of the age-groups tested. Likewise, no correlation was found either between serum PC/PI mole ratio or membrane fluidity and mitogen responsiveness of PBL from birds up to 5 years of age nor was there any evidence for a decline in mitogen responsiveness up to this age. Supplementation of diets with 1% cholesterol induced hypercholesterolemia, mainly in the very low density lipoprotein (VLDL) fraction, but membrane fluidity and mitogen responsiveness remained unaffected.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>6513612</pmid><doi>10.1016/0047-6374(84)90158-1</doi><tpages>16</tpages></addata></record> |
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| ispartof | Mechanisms of ageing and development, 1984-01, Vol.28 (1), p.123-138 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Age Aging Animals Cell Membrane - physiology chickens Chickens - immunology Chickens - physiology Cholesterol Cholesterol - blood Cholesterol - pharmacology Female Lipids Lipids - blood Lipoproteins - blood lymphocytes Lymphocytes - drug effects Lymphocytes - physiology Membrane Fluidity Mitogen response mitogens Mitogens - pharmacology plasma membranes |
| title | Lack of correlation between serum cholesterol levels, lymphocyte plasma membrane fluidity and mitogen responsiveness in young and aged chickens |
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