Transport of deoxycoformycin in human erythrocytes: Measurement by adenosine deaminase titration and radioisotope assays

The assay of residual adenosine deaminase (ADA) activity was used as a sensitive measure of the transport of deoxycoformycin (dCF) into human erythrocytes. Contrary to prior reports from this laboratory, the inactivation of intraerythrocytic ADA by dCF was linear rather than log-linear, with time. L...

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Veröffentlicht in:	Biochemical pharmacology 1984-12, Vol.33 (24), p.4069-4079
Hauptverfasser:	Shih-Fong, Chen, Stoeckler, Johanna D., Parks, Robert E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Deaminase Inhibitors Antineoplastic agents Biological and medical sciences Biological Transport Coformycin - analogs & derivatives Coformycin - blood deoxycoformycin Dipyridamole - pharmacology erythrocytes Erythrocytes - metabolism General aspects Humans Kinetics man Medical sciences Nucleoside Deaminases - antagonists & inhibitors Nucleosides - metabolism Pentostatin Pharmacology. Drug treatments Ribonucleosides - blood Thioinosine - analogs & derivatives Thioinosine - pharmacology Tritium Uridine - pharmacology
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