Hypolipidemic activity of HOE-402 is mediated by stimulation of the LDL receptor pathway

HOE-402 (4-amino-2-[4,4-dimethyl-2-oxo-1-imidazolidinyl]-pyrimidine-5-N- [trifluoromethylphenyl]-carboxamide-monohydrochloride) has been shown to exhibit hypolipidemic action in heterozygous Watanabe heritable hyperlipidemic rabbits. In all animals, elevated cholesterol levels were reduced to normal...

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Veröffentlicht in:	Arteriosclerosis and thrombosis 1993-07, Vol.13 (7), p.1005-1012
Hauptverfasser:	HUETTINGER, M, HERMANN, M, GOLDENBERG, H, GRANZER, E, LEINEWEBER, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Endocytosis - physiology Gene Expression Regulation - drug effects General and cellular metabolism. Vitamins Heterozygote Humans Hyperlipidemias - genetics Imidazoles - pharmacology Iron - analysis Iron - physiology Lipids - blood Lipoproteins, LDL - analysis Male Medical sciences Pharmacology. Drug treatments Pyrimidines - pharmacology Rabbits Receptors, LDL - genetics Receptors, LDL - physiology RNA, Messenger - analysis RNA, Messenger - genetics Transferrin - analysis Transferrin - physiology Tumor Cells, Cultured - chemistry
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