An epitope on the surface envelope glycoprotein (gp130) of simian immunodeficiency virus (SIVmac) involved in viral neutralization and T cell activation

SIVmac infection of macaques is an important animal model for HIV infection and AIDS; this model is being utilized for development of antiviral therapies and vaccines. In the present article, we sought to identify neutralization epitopes of SIVmac envelope surface glycoprotein (gp130). Algorithms we...

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Veröffentlicht in:	AIDS research and human retroviruses 1993-05, Vol.9 (5), p.423-430
Hauptverfasser:	TORRES, J. V, MALLEY, A, BABAK BANAPOUR, ANDERSON, D. E, AXTHELM, M. K, GARDNER, M. B, BENJAMINI, E
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Vaccines - isolation & purification AIDS/HIV Amino Acid Sequence Animals Antigens, Viral - genetics Biological and medical sciences Epitopes - genetics Fundamental and applied biological sciences. Psychology Gene Products, env - genetics Gene Products, env - immunology Lymphocyte Activation Macaca mulatta Mice Microbiology Molecular Sequence Data Neutralization Tests Peptide Fragments - genetics Peptide Fragments - immunology Rabbits Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Retroviridae Proteins, Oncogenic - genetics Retroviridae Proteins, Oncogenic - immunology Simian Acquired Immunodeficiency Syndrome - immunology simian immunodeficiency virus Simian Immunodeficiency Virus - genetics Simian Immunodeficiency Virus - immunology T-Lymphocytes - immunology Viral Fusion Proteins Virology
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