Enhanced urinary excretion of leukotriene E4 in patients with mevalonate kinase deficiency
In patients with mevalonate kinase deficiency, urinary excretion of the leukotriene LTE 4 was found to be elevated. A positive linear relationship between increased urinary excretion of mevalonate and LTE 4 (n=5) suggests that increased cysteinyl leukotriene synthesis is involved in the pathomechani...
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| Veröffentlicht in: | The Journal of pediatrics 1993-07, Vol.123 (1), p.96-98 |
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| container_issue | 1 |
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| container_title | The Journal of pediatrics |
| container_volume | 123 |
| creator | Mayatepek, Ertan Hoffmann, Georg F. Bremer, Hans J. |
| description | In patients with mevalonate kinase deficiency, urinary excretion of the leukotriene LTE
4 was found to be elevated. A positive linear relationship between increased urinary excretion of mevalonate and LTE
4 (n=5) suggests that increased cysteinyl leukotriene synthesis is involved in the pathomechanisms of this disease. |
| doi_str_mv | 10.1016/S0022-3476(05)81548-3 |
| format | Article |
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4 was found to be elevated. A positive linear relationship between increased urinary excretion of mevalonate and LTE
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| fulltext | fulltext |
| identifier | ISSN: 0022-3476 |
| ispartof | The Journal of pediatrics, 1993-07, Vol.123 (1), p.96-98 |
| issn | 0022-3476 1097-6833 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biological and medical sciences Child Child, Preschool Chromatography, High Pressure Liquid Errors of metabolism Female Gas Chromatography-Mass Spectrometry Humans Leukotriene E4 Lipids (lysosomal enzyme disorders, storage diseases) Male Medical sciences Metabolic diseases Mevalonic Acid - urine Phosphotransferases (Alcohol Group Acceptor) Phosphotransferases - deficiency SRS-A - analogs & derivatives SRS-A - urine Urine - cytology |
| title | Enhanced urinary excretion of leukotriene E4 in patients with mevalonate kinase deficiency |
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