Hepatitis C in dialysis patients: Relationship to blood transfusions, dialysis and liver disease
Hepatitis C in dialysis patients: Relationship to blood transfusions, dialysis and liver disease. Antibodies to hepatitis C virus (anti-HCV) were determined in an unselected group of 340 patients with chronic renal failure treated with maintenance dialysis. A second generation hepatitis C virus (HCV...
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| Veröffentlicht in: | Kidney international 1993-06, Vol.43 (6), p.1353-1356 |
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| creator | Knudsen, Freddy Wantzin, Per Rasmussen, Knud Ladefoged, Søren D. Løkkegaard, Niels Rasmussen, Lars S. Lassen, Anders Krogsgaard, Kim |
| description | Hepatitis C in dialysis patients: Relationship to blood transfusions, dialysis and liver disease. Antibodies to hepatitis C virus (anti-HCV) were determined in an unselected group of 340 patients with chronic renal failure treated with maintenance dialysis. A second generation hepatitis C virus (HCV) enzyme-linked immunosorbent assay (ELISA) was used and confirmation made by a second generation recombinant immunoblot assay (RIBA). Sixteen patients (4.7%) were anti-HCV positive and 8 (2.4%) were anti-HCV indeterminate. All anti-HCV positive and anti-HCV indeterminate patients had received blood transfusions. No statistically significant differences were found between anti-HCV positive and indeterminate patients considering blood transfusions, dialysis and liver disease. The combined group of anti-HCV positive and indeterminate patients had had more blood transfusions (P < 0.005) and had been on dialysis for a longer period (P < 0.01) compared with anti-HCV negative patients. Further, significant correlation with elevation of transaminases and anti-HCV was observed (P < 0.001). Thirty patients (8.8%) had elevated transaminase levels and 13 (43%) of these were anti-HCV positive or indeterminate. In conclusion, HCV infection accounts for a substantial proportion of liver disease in dialysis patients, probably most often transmitted by blood transfusions but other routes of transmission could not be excluded. |
| doi_str_mv | 10.1038/ki.1993.190 |
| format | Article |
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Antibodies to hepatitis C virus (anti-HCV) were determined in an unselected group of 340 patients with chronic renal failure treated with maintenance dialysis. A second generation hepatitis C virus (HCV) enzyme-linked immunosorbent assay (ELISA) was used and confirmation made by a second generation recombinant immunoblot assay (RIBA). Sixteen patients (4.7%) were anti-HCV positive and 8 (2.4%) were anti-HCV indeterminate. All anti-HCV positive and anti-HCV indeterminate patients had received blood transfusions. No statistically significant differences were found between anti-HCV positive and indeterminate patients considering blood transfusions, dialysis and liver disease. The combined group of anti-HCV positive and indeterminate patients had had more blood transfusions (P < 0.005) and had been on dialysis for a longer period (P < 0.01) compared with anti-HCV negative patients. Further, significant correlation with elevation of transaminases and anti-HCV was observed (P < 0.001). Thirty patients (8.8%) had elevated transaminase levels and 13 (43%) of these were anti-HCV positive or indeterminate. In conclusion, HCV infection accounts for a substantial proportion of liver disease in dialysis patients, probably most often transmitted by blood transfusions but other routes of transmission could not be excluded.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1038/ki.1993.190</identifier><identifier>PMID: 7686238</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alanine Transaminase - blood ; Aspartate Aminotransferases - blood ; Child ; Enzyme-Linked Immunosorbent Assay ; Female ; Hepatitis Antibodies - blood ; Hepatitis C - etiology ; Hepatitis C - transmission ; Hepatitis C Antibodies ; Humans ; Liver Diseases - etiology ; Male ; Middle Aged ; Renal Dialysis - adverse effects ; Transfusion Reaction</subject><ispartof>Kidney international, 1993-06, Vol.43 (6), p.1353-1356</ispartof><rights>1993 International Society of Nephrology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-fccdb8d2f8eac7f4fdde23fbaa7c2c2f77f4823b75bf465fa1f3665c35e3c893</citedby><cites>FETCH-LOGICAL-c391t-fccdb8d2f8eac7f4fdde23fbaa7c2c2f77f4823b75bf465fa1f3665c35e3c893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7686238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Knudsen, Freddy</creatorcontrib><creatorcontrib>Wantzin, Per</creatorcontrib><creatorcontrib>Rasmussen, Knud</creatorcontrib><creatorcontrib>Ladefoged, Søren D.</creatorcontrib><creatorcontrib>Løkkegaard, Niels</creatorcontrib><creatorcontrib>Rasmussen, Lars S.</creatorcontrib><creatorcontrib>Lassen, Anders</creatorcontrib><creatorcontrib>Krogsgaard, Kim</creatorcontrib><title>Hepatitis C in dialysis patients: Relationship to blood transfusions, dialysis and liver disease</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>Hepatitis C in dialysis patients: Relationship to blood transfusions, dialysis and liver disease. Antibodies to hepatitis C virus (anti-HCV) were determined in an unselected group of 340 patients with chronic renal failure treated with maintenance dialysis. A second generation hepatitis C virus (HCV) enzyme-linked immunosorbent assay (ELISA) was used and confirmation made by a second generation recombinant immunoblot assay (RIBA). Sixteen patients (4.7%) were anti-HCV positive and 8 (2.4%) were anti-HCV indeterminate. All anti-HCV positive and anti-HCV indeterminate patients had received blood transfusions. No statistically significant differences were found between anti-HCV positive and indeterminate patients considering blood transfusions, dialysis and liver disease. The combined group of anti-HCV positive and indeterminate patients had had more blood transfusions (P < 0.005) and had been on dialysis for a longer period (P < 0.01) compared with anti-HCV negative patients. Further, significant correlation with elevation of transaminases and anti-HCV was observed (P < 0.001). Thirty patients (8.8%) had elevated transaminase levels and 13 (43%) of these were anti-HCV positive or indeterminate. In conclusion, HCV infection accounts for a substantial proportion of liver disease in dialysis patients, probably most often transmitted by blood transfusions but other routes of transmission could not be excluded.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alanine Transaminase - blood</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Child</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Hepatitis Antibodies - blood</subject><subject>Hepatitis C - etiology</subject><subject>Hepatitis C - transmission</subject><subject>Hepatitis C Antibodies</subject><subject>Humans</subject><subject>Liver Diseases - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Renal Dialysis - adverse effects</subject><subject>Transfusion Reaction</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptUE1LxDAUDKLo-nHyLPbkRatJY9qsN1n8ggVBvMc0ecG43XbNSxf235vSRS9e3sfMZMIbQk4ZvWaUy5uFv2bTKU-F7pAJEwXPWSXELplQKkVeCC4PyCHiF037lNN9sl-Vsiy4nJCPZ1jp6KPHbJb5NrNeNxtM24BCG_Eue4MmzV2Ln36VxS6rm66zWQy6RdfjQFz9PdOtzRq_hpAgBI1wTPacbhBOtv2IvD8-vM-e8_nr08vsfp4bPmUxd8bYWtrCSdCmcrfOWii4q7WuTGEKVyVMFryuRO1uS-E0c7wsheECuElHHZGL0XYVuu8eMKqlRwNNo1voelSVkEyUlCfh5Sg0oUMM4NQq-KUOG8WoGuJUC6-GOFOhSX22te3rJdhf7Ta_xJ-PfKtjH-CXX_jBYnQQowLS8WsPQaFJwRqwPoCJynb-359_ADclj20</recordid><startdate>19930601</startdate><enddate>19930601</enddate><creator>Knudsen, Freddy</creator><creator>Wantzin, Per</creator><creator>Rasmussen, Knud</creator><creator>Ladefoged, Søren D.</creator><creator>Løkkegaard, Niels</creator><creator>Rasmussen, Lars S.</creator><creator>Lassen, Anders</creator><creator>Krogsgaard, Kim</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930601</creationdate><title>Hepatitis C in dialysis patients: Relationship to blood transfusions, dialysis and liver disease</title><author>Knudsen, Freddy ; 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Antibodies to hepatitis C virus (anti-HCV) were determined in an unselected group of 340 patients with chronic renal failure treated with maintenance dialysis. A second generation hepatitis C virus (HCV) enzyme-linked immunosorbent assay (ELISA) was used and confirmation made by a second generation recombinant immunoblot assay (RIBA). Sixteen patients (4.7%) were anti-HCV positive and 8 (2.4%) were anti-HCV indeterminate. All anti-HCV positive and anti-HCV indeterminate patients had received blood transfusions. No statistically significant differences were found between anti-HCV positive and indeterminate patients considering blood transfusions, dialysis and liver disease. The combined group of anti-HCV positive and indeterminate patients had had more blood transfusions (P < 0.005) and had been on dialysis for a longer period (P < 0.01) compared with anti-HCV negative patients. Further, significant correlation with elevation of transaminases and anti-HCV was observed (P < 0.001). Thirty patients (8.8%) had elevated transaminase levels and 13 (43%) of these were anti-HCV positive or indeterminate. In conclusion, HCV infection accounts for a substantial proportion of liver disease in dialysis patients, probably most often transmitted by blood transfusions but other routes of transmission could not be excluded.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7686238</pmid><doi>10.1038/ki.1993.190</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Aged, 80 and over Alanine Transaminase - blood Aspartate Aminotransferases - blood Child Enzyme-Linked Immunosorbent Assay Female Hepatitis Antibodies - blood Hepatitis C - etiology Hepatitis C - transmission Hepatitis C Antibodies Humans Liver Diseases - etiology Male Middle Aged Renal Dialysis - adverse effects Transfusion Reaction |
| title | Hepatitis C in dialysis patients: Relationship to blood transfusions, dialysis and liver disease |
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