Positron emission tomography study of [ 11C]methyl-tetrahydroaminoacridine (methyl-tacrine) in baboon brain

THA (1,2,3,4-tetrahydro-9-amino-acridine, tacrine), a potential therapeutic agent for patients suffering from Alzheimer's disease, has multiple pharmacological sites of action in the brain. In order to study the cerebral binding sites of THA in vivo, we labeled a close derivative of THA with ca...

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Veröffentlicht in:	European journal of pharmacology 1993-05, Vol.236 (2), p.229-238
Hauptverfasser:	Tavitian, Bertrand, Pappata, Sabina, Bonnot-Lours, Sophie, Prenant, Christian, Jobert, Antoinette, Crouzel, Christian, Di Giamberardino, Luigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - metabolism Alzheimer's disease Animals Baboon Binding Sites Biological and medical sciences Brain - drug effects Brain - metabolism Cholinesterase Inhibitors - pharmacology Injections, Intravenous Male Medical sciences Miscellaneous Neuropharmacology Papio PET (positron emission tomography) Pharmacology. Drug treatments Primates Rat Rats Rats, Sprague-Dawley Tacrine - analogs & derivatives Tacrine - metabolism Tacrine - pharmacokinetics Tacrine - pharmacology Tetrahydroaminoacridine (THA, tacrine) Tissue Distribution Tomography, Emission-Computed
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