Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments
We previously reported that tau protein kinase I (TPKI) induced normal tau protein into a state of paired helical filaments (PHF); this is further confirmed here by immunoblot analysis using several antibodies. We also present the amino acid sequence of TPKI, which is identical to glycogen synthase...
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| Veröffentlicht in: | FEBS letters 1993-07, Vol.325 (3), p.167-172 |
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| creator | Ishiguro, Koichi Shiratsuchi, Akiko Sato, Showbu Omori, Akira Arioka, Manabu Kobayashi, Shunsuke Uchida, Tsuneko Imahori, Kazutomo |
| description | We previously reported that tau protein kinase I (TPKI) induced normal tau protein into a state of paired helical filaments (PHF); this is further confirmed here by immunoblot analysis using several antibodies. We also present the amino acid sequence of TPKI, which is identical to glycogen synthase kinase 3β (GSK3β). Moreover, we found that TPKI activity was inseparable from GSK3 activity throughout the purification procedure. These results indicate that TPKI is identical to GSK3β. |
| doi_str_mv | 10.1016/0014-5793(93)81066-9 |
| format | Article |
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Prion diseases ; DNA ; Epitopes ; Glycogen Synthase Kinase 3 ; Glycogen synthase kinase 3β ; Glycogen Synthase Kinases ; Humans ; Immunoblotting ; Medical sciences ; Molecular Sequence Data ; Neurology ; Paired helical filament ; Phosphorylation ; Protein kinase ; Protein Kinases - chemistry ; Protein Kinases - immunology ; Protein-Serine-Threonine Kinases - chemistry ; Protein-Serine-Threonine Kinases - immunology ; Rats ; Substrate Specificity ; Tau protein</subject><ispartof>FEBS letters, 1993-07, Vol.325 (3), p.167-172</ispartof><rights>1993</rights><rights>FEBS Letters 325 (1993) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4959-e291bbeede6394c2a23ef5a166e5f4f4054b316ee3f3ed164c0f7f1dd4a7f2cb3</citedby><cites>FETCH-LOGICAL-c4959-e291bbeede6394c2a23ef5a166e5f4f4054b316ee3f3ed164c0f7f1dd4a7f2cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014579393810669$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4824151$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7686508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishiguro, Koichi</creatorcontrib><creatorcontrib>Shiratsuchi, Akiko</creatorcontrib><creatorcontrib>Sato, Showbu</creatorcontrib><creatorcontrib>Omori, Akira</creatorcontrib><creatorcontrib>Arioka, Manabu</creatorcontrib><creatorcontrib>Kobayashi, Shunsuke</creatorcontrib><creatorcontrib>Uchida, Tsuneko</creatorcontrib><creatorcontrib>Imahori, Kazutomo</creatorcontrib><title>Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>We previously reported that tau protein kinase I (TPKI) induced normal tau protein into a state of paired helical filaments (PHF); this is further confirmed here by immunoblot analysis using several antibodies. We also present the amino acid sequence of TPKI, which is identical to glycogen synthase kinase 3β (GSK3β). Moreover, we found that TPKI activity was inseparable from GSK3 activity throughout the purification procedure. These results indicate that TPKI is identical to GSK3β.</description><subject>Alzheimer's disease</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Calcium-Calmodulin-Dependent Protein Kinases</subject><subject>Cattle</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>DNA</subject><subject>Epitopes</subject><subject>Glycogen Synthase Kinase 3</subject><subject>Glycogen synthase kinase 3β</subject><subject>Glycogen Synthase Kinases</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Neurology</subject><subject>Paired helical filament</subject><subject>Phosphorylation</subject><subject>Protein kinase</subject><subject>Protein Kinases - chemistry</subject><subject>Protein Kinases - immunology</subject><subject>Protein-Serine-Threonine Kinases - chemistry</subject><subject>Protein-Serine-Threonine Kinases - immunology</subject><subject>Rats</subject><subject>Substrate Specificity</subject><subject>Tau protein</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcGOFCEQhonRrOPoG2jCwRj30AoNTcPFRDc76yabeNEzoaHYRZnutmHW9Gv5ID6T9MzsHI0JSUHVXz_FB0IvKXlHCRXvCaG8alrF3ip2LikRolKP0IrKllWMC_kYrU6Sp-hZSt9JOUuqztBZK6RoiFyh-SrOdriFHqe5z3cmAf4R-iWwP79xSDg46HOwJuI84Gx2eJyGDKF_kF3j0gyTyaG_xQnuyzZiGEMeRkh48Hg0YQKH7yDuXXyIZlss03P0xJuY4MUxrtG3zeXXi8_VzZer64uPN5XlqlEV1Ip2HYADwRS3takZ-MZQIaDx3HPS8I5RAcA8A0cFt8S3njrHTetr27E1enPwLYP_3EHKehuShRhND8Mu6baRlEvaFiE_CO00pDSB1-MUtmaaNSV6Ia4XnHrBqcvaEy-bNXp19N91W3CnpiPiUn99rJtUAPjJ9Dakk4zLmtOGFtnmIPsVIsz_dbXeXH6ql8KSV2yfXeb5cDCCAvU-wKSTDdBbcOUfbNZuCP9-0F94HLL1</recordid><startdate>19930705</startdate><enddate>19930705</enddate><creator>Ishiguro, Koichi</creator><creator>Shiratsuchi, Akiko</creator><creator>Sato, Showbu</creator><creator>Omori, Akira</creator><creator>Arioka, Manabu</creator><creator>Kobayashi, Shunsuke</creator><creator>Uchida, Tsuneko</creator><creator>Imahori, Kazutomo</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930705</creationdate><title>Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments</title><author>Ishiguro, Koichi ; Shiratsuchi, Akiko ; Sato, Showbu ; Omori, Akira ; Arioka, Manabu ; Kobayashi, Shunsuke ; Uchida, Tsuneko ; Imahori, Kazutomo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4959-e291bbeede6394c2a23ef5a166e5f4f4054b316ee3f3ed164c0f7f1dd4a7f2cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Alzheimer's disease</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Calcium-Calmodulin-Dependent Protein Kinases</topic><topic>Cattle</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>DNA</topic><topic>Epitopes</topic><topic>Glycogen Synthase Kinase 3</topic><topic>Glycogen synthase kinase 3β</topic><topic>Glycogen Synthase Kinases</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Neurology</topic><topic>Paired helical filament</topic><topic>Phosphorylation</topic><topic>Protein kinase</topic><topic>Protein Kinases - chemistry</topic><topic>Protein Kinases - immunology</topic><topic>Protein-Serine-Threonine Kinases - chemistry</topic><topic>Protein-Serine-Threonine Kinases - immunology</topic><topic>Rats</topic><topic>Substrate Specificity</topic><topic>Tau protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishiguro, Koichi</creatorcontrib><creatorcontrib>Shiratsuchi, Akiko</creatorcontrib><creatorcontrib>Sato, Showbu</creatorcontrib><creatorcontrib>Omori, Akira</creatorcontrib><creatorcontrib>Arioka, Manabu</creatorcontrib><creatorcontrib>Kobayashi, Shunsuke</creatorcontrib><creatorcontrib>Uchida, Tsuneko</creatorcontrib><creatorcontrib>Imahori, Kazutomo</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishiguro, Koichi</au><au>Shiratsuchi, Akiko</au><au>Sato, Showbu</au><au>Omori, Akira</au><au>Arioka, Manabu</au><au>Kobayashi, Shunsuke</au><au>Uchida, Tsuneko</au><au>Imahori, Kazutomo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1993-07-05</date><risdate>1993</risdate><volume>325</volume><issue>3</issue><spage>167</spage><epage>172</epage><pages>167-172</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>We previously reported that tau protein kinase I (TPKI) induced normal tau protein into a state of paired helical filaments (PHF); this is further confirmed here by immunoblot analysis using several antibodies. We also present the amino acid sequence of TPKI, which is identical to glycogen synthase kinase 3β (GSK3β). Moreover, we found that TPKI activity was inseparable from GSK3 activity throughout the purification procedure. These results indicate that TPKI is identical to GSK3β.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>7686508</pmid><doi>10.1016/0014-5793(93)81066-9</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEBS letters, 1993-07, Vol.325 (3), p.167-172 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Alzheimer's disease Amino Acid Sequence Animals Base Sequence Biological and medical sciences Calcium-Calmodulin-Dependent Protein Kinases Cattle Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA Epitopes Glycogen Synthase Kinase 3 Glycogen synthase kinase 3β Glycogen Synthase Kinases Humans Immunoblotting Medical sciences Molecular Sequence Data Neurology Paired helical filament Phosphorylation Protein kinase Protein Kinases - chemistry Protein Kinases - immunology Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - immunology Rats Substrate Specificity Tau protein |
| title | Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments |
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