A p120-catenin-CK1epsilon complex regulates Wnt signaling

p120-catenin is an E-cadherin-associated protein that modulates E-cadherin function and stability. We describe here that p120-catenin is required for Wnt pathway signaling. p120-catenin binds and is phosphorylated by CK1ε in response to Wnt3a. p120-catenin also associates to the Wnt co-receptor LRP5...

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Veröffentlicht in:	Journal of cell science 2010-08, Vol.123 (Pt 15), p.2621-2631
Hauptverfasser:	Casagolda, David, Del Valle-Pérez, Beatriz, Valls, Gabriela, Lugilde, Ero, Vinyoles, Meritxell, Casado-Vela, Juan, Solanas, Guiomar, Batlle, Eduard, Reynolds, Albert B, Casal, José Ignacio, de Herreros, Antonio García, Duñach, Mireia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Cadherins - genetics Cadherins - metabolism Casein Kinase 1 epsilon - genetics Casein Kinase 1 epsilon - metabolism Catenins - genetics Catenins - metabolism Cell Line, Tumor Delta Catenin Dishevelled Proteins Humans Immunoprecipitation LDL-Receptor Related Proteins - metabolism Low Density Lipoprotein Receptor-Related Protein-5 Low Density Lipoprotein Receptor-Related Protein-6 Mass Spectrometry Phosphoproteins - metabolism Phosphorylation - drug effects Protein Binding - drug effects Protein Binding - genetics Signal Transduction - drug effects Signal Transduction - genetics Wnt Proteins - pharmacology
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