Hematopoietic SCT modulates gut inflammation in experimental inflammatory bowel disease

Hematopoietic SCT (HSCT) and high-dose chemotherapy are being explored as therapy for various human refractory immune-mediated conditions, including inflammatory bowel diseases (IBD). Nevertheless, the exact immunological mechanisms by which the BM cells (BMCs) or immunosuppression provide remission...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2010-10, Vol.45 (10), p.1562-1571
Hauptverfasser:	Godoi, D F, Cardoso, C R, Ferraz, D B, Provinciatto, P R, Cunha, F Q, Silva, J S, Voltarelli, J C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/347 692/699/1503/257 692/700/565/1436/99 692/700/565/545/576/1955 Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Bone marrow Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Care and treatment CD4 antigen CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - pathology CD8 antigen CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Cell Biology Chemotherapy Colitis Colitis - drug therapy Colitis - immunology Colitis - pathology Colitis - therapy Combined Modality Therapy Cyclosporine - administration & dosage Cyclosporine - therapeutic use Cytokines Cytokines - metabolism Diagnosis Dosage Female Gastroenterology. Liver. Pancreas. Abdomen Health aspects Helper cells Hematology Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Immune reconstitution Immune response Immunity, Mucosal - drug effects Immunology Immunosuppression Immunosuppression - methods Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - therapeutic use Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - pathology Inflammatory Bowel Diseases - therapy Internal Medicine Intestine Leukocytes Lymphocytes T Male Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred BALB C Modulation Mucosal immunity original-article Other diseases. Semiology Public Health Remission Severity of Illness Index Stem cell transplantation Stem Cells Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Survival Analysis Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Trinitrobenzenesulfonic Acid - toxicity
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