Concise Total Synthesis of the Potent Translation and Cell Migration Inhibitor Lactimidomycin

An efficient total synthesis of the antiproliferative macrolide and cell migration inhibitor lactimidomycin (3) is reported, which relies on the performance of ring closing alkyne metathesis (RCAM). The strained 12-membered 1,3-enyne 21 as the key intermediate was forged with the aid of [(Ph3SiO)3Mo...

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Veröffentlicht in:	Journal of the American Chemical Society 2010-10, Vol.132 (40), p.14064-14066
Hauptverfasser:	Micoine, Kevin, Fürstner, Alois
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Movement - drug effects Humans Macrolides - chemical synthesis Macrolides - pharmacology Piperidones - chemical synthesis Piperidones - pharmacology Protein Biosynthesis - drug effects
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