Targeted delivery of a heme oxygenase inhibitor with a lyophilized liposomal tin mesoporphyrin formulation

Tin mesoporphyrin (SnMP) is a competitive inhibitor of heme oxygenase being examined clinically for the treatment of hyperbilirubinemia. Since liposomes have been shown to target SnMP to the spleen and increase its efficacy (S. A. Landaw, G. S. Drummond, and A. Kappas, Pediatrics 84, 1091-1096, 1989...

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Veröffentlicht in:	Pharmaceutical research 1993-05, Vol.10 (5), p.715-721
Hauptverfasser:	CANNON, J. B, MARTIN, C, DRUMMOND, G. S, KAPPAS, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bilirubin - metabolism Biological and medical sciences Buffers Drug Carriers Freeze Drying General and cellular metabolism. Vitamins Heme Oxygenase (Decyclizing) - antagonists & inhibitors Hydrogen-Ion Concentration Liposomes Medical sciences Metalloporphyrins - administration & dosage Metalloporphyrins - pharmacokinetics Metalloporphyrins - pharmacology Pharmacology. Drug treatments Rats Spleen - drug effects Spleen - metabolism Tissue Distribution
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