Alteration of Hepatic DNA Synthesis in Rats Treated with N-Nitrosodimethylamine during Early Stages of Copper Deficiency
The main aim of this research was to clarify that nutritional dietary copper may participate in the protective action against hepatocarcinogenesis in rats by N-nitrosodimethylamine (NDMA). The copper concentrations in serum and liver from 2 to 8 d after rats were first fed a copper deficient diet (c...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1993/04/15, Vol.41(4), pp.769-771 |
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| creator | SAKAI, Kazuo MURATA, Nozomu FUKINO, Hideki YAMANE, Yasuhiro |
| description | The main aim of this research was to clarify that nutritional dietary copper may participate in the protective action against hepatocarcinogenesis in rats by N-nitrosodimethylamine (NDMA). The copper concentrations in serum and liver from 2 to 8 d after rats were first fed a copper deficient diet (copper, 0.6 ppm) decreased significantly compared to those of pair-fed rats (copper in a control diet, 7 ppm). The subcellular distribution of copper in the liver at 5 d after feeding of a copper deficient diet began was measured and the copper concentrations in soluble and nuclear fractions decreased at a similar rate in copper deficient rats treated with or without NDMA, compared to those of pair-fed rats. The incorporation of [3H]thymidine into rat liver DNA at 48 h after treatment with NDMA markedly increased under the experimental conditions used. By giving rats a copper deficient diet for a few days the increased incorporation of [3H]thymidine into liver DNA of rats treated with NDMA was enhanced compared to that of pair-fed rats treated with NDMA. The activity of thymidine kinase in liver of copper deficient rats treated with NDMA was also found to increase ingnificantly compared to that of pair-fed rats treated with NDMA. |
| doi_str_mv | 10.1248/cpb.41.769 |
| format | Article |
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The copper concentrations in serum and liver from 2 to 8 d after rats were first fed a copper deficient diet (copper, 0.6 ppm) decreased significantly compared to those of pair-fed rats (copper in a control diet, 7 ppm). The subcellular distribution of copper in the liver at 5 d after feeding of a copper deficient diet began was measured and the copper concentrations in soluble and nuclear fractions decreased at a similar rate in copper deficient rats treated with or without NDMA, compared to those of pair-fed rats. The incorporation of [3H]thymidine into rat liver DNA at 48 h after treatment with NDMA markedly increased under the experimental conditions used. By giving rats a copper deficient diet for a few days the increased incorporation of [3H]thymidine into liver DNA of rats treated with NDMA was enhanced compared to that of pair-fed rats treated with NDMA. The activity of thymidine kinase in liver of copper deficient rats treated with NDMA was also found to increase ingnificantly compared to that of pair-fed rats treated with NDMA.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.41.769</identifier><identifier>PMID: 8508479</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Chemical agents ; Copper - deficiency ; Copper - metabolism ; Dimethylnitrosamine - pharmacology ; DNA - biosynthesis ; DNA - drug effects ; Liver - drug effects ; Liver - metabolism ; Male ; Medical sciences ; N-nitrosodimethylamine ; rat liver DNA synthesis ; Rats ; Rats, Wistar ; Thymidine Kinase - metabolism ; Tumors</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1993/04/15, Vol.41(4), pp.769-771</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1993 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1993</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4871569$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8508479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SAKAI, Kazuo</creatorcontrib><creatorcontrib>MURATA, Nozomu</creatorcontrib><creatorcontrib>FUKINO, Hideki</creatorcontrib><creatorcontrib>YAMANE, Yasuhiro</creatorcontrib><title>Alteration of Hepatic DNA Synthesis in Rats Treated with N-Nitrosodimethylamine during Early Stages of Copper Deficiency</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>The main aim of this research was to clarify that nutritional dietary copper may participate in the protective action against hepatocarcinogenesis in rats by N-nitrosodimethylamine (NDMA). The copper concentrations in serum and liver from 2 to 8 d after rats were first fed a copper deficient diet (copper, 0.6 ppm) decreased significantly compared to those of pair-fed rats (copper in a control diet, 7 ppm). The subcellular distribution of copper in the liver at 5 d after feeding of a copper deficient diet began was measured and the copper concentrations in soluble and nuclear fractions decreased at a similar rate in copper deficient rats treated with or without NDMA, compared to those of pair-fed rats. The incorporation of [3H]thymidine into rat liver DNA at 48 h after treatment with NDMA markedly increased under the experimental conditions used. By giving rats a copper deficient diet for a few days the increased incorporation of [3H]thymidine into liver DNA of rats treated with NDMA was enhanced compared to that of pair-fed rats treated with NDMA. The activity of thymidine kinase in liver of copper deficient rats treated with NDMA was also found to increase ingnificantly compared to that of pair-fed rats treated with NDMA.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Chemical agents</subject><subject>Copper - deficiency</subject><subject>Copper - metabolism</subject><subject>Dimethylnitrosamine - pharmacology</subject><subject>DNA - biosynthesis</subject><subject>DNA - drug effects</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>N-nitrosodimethylamine</subject><subject>rat liver DNA synthesis</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Thymidine Kinase - metabolism</subject><subject>Tumors</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd2L1DAUxYMo67j64rsQcPFhoWM-2_RxmF13hWUEd30OaXq7k6GT1iRF-9_b2mEEX5IL58e5Hweh95SsKRPqs-2rtaDrIi9foBXlosgkY_wlWhFCyozxnL9Gb2I8EMIkKfgFulCSKFGUK_R70yYIJrnO467B99BPtcU3uw1-HH3aQ3QRO4-_mxTxUwCToMa_XNrjXbZzKXSxq90R0n5szdF5wPUQnH_Gtya0I35M5hnibLzt-h4CvoHGWQfejm_Rq8a0Ed6d_kv048vt0_Y-e_h293W7ecisYDRlQGqSl7KuqzxnvDSNLaeqIpwwpjg01lSKACgFRKrGiprKnNeVzUUhDbeKX6JPi28fup8DxKSPLlpoW-OhG6IupKJM5uUEfvwPPHRD8NNsmoqcMFWQcqauF8pOq8cAje6DO5owakr0HIaewtCC6uKv5YeT5VAdoT6jp-tP-tVJN9GatgnGWxfPmFAFXSbbLtghzvc86yZMUbUwd6SlVHNXsTxT83_q3gQNnv8BAT2p6w</recordid><startdate>19930401</startdate><enddate>19930401</enddate><creator>SAKAI, Kazuo</creator><creator>MURATA, Nozomu</creator><creator>FUKINO, Hideki</creator><creator>YAMANE, Yasuhiro</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19930401</creationdate><title>Alteration of Hepatic DNA Synthesis in Rats Treated with N-Nitrosodimethylamine during Early Stages of Copper Deficiency</title><author>SAKAI, Kazuo ; MURATA, Nozomu ; FUKINO, Hideki ; YAMANE, Yasuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-e0d0695ddb66239afc9b66b0302283efcab80ee88e058fc4d1563dbc6475a3c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Chemical agents</topic><topic>Copper - deficiency</topic><topic>Copper - metabolism</topic><topic>Dimethylnitrosamine - pharmacology</topic><topic>DNA - biosynthesis</topic><topic>DNA - drug effects</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>N-nitrosodimethylamine</topic><topic>rat liver DNA synthesis</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Thymidine Kinase - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SAKAI, Kazuo</creatorcontrib><creatorcontrib>MURATA, Nozomu</creatorcontrib><creatorcontrib>FUKINO, Hideki</creatorcontrib><creatorcontrib>YAMANE, Yasuhiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SAKAI, Kazuo</au><au>MURATA, Nozomu</au><au>FUKINO, Hideki</au><au>YAMANE, Yasuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alteration of Hepatic DNA Synthesis in Rats Treated with N-Nitrosodimethylamine during Early Stages of Copper Deficiency</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1993-04-01</date><risdate>1993</risdate><volume>41</volume><issue>4</issue><spage>769</spage><epage>771</epage><pages>769-771</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>The main aim of this research was to clarify that nutritional dietary copper may participate in the protective action against hepatocarcinogenesis in rats by N-nitrosodimethylamine (NDMA). The copper concentrations in serum and liver from 2 to 8 d after rats were first fed a copper deficient diet (copper, 0.6 ppm) decreased significantly compared to those of pair-fed rats (copper in a control diet, 7 ppm). The subcellular distribution of copper in the liver at 5 d after feeding of a copper deficient diet began was measured and the copper concentrations in soluble and nuclear fractions decreased at a similar rate in copper deficient rats treated with or without NDMA, compared to those of pair-fed rats. The incorporation of [3H]thymidine into rat liver DNA at 48 h after treatment with NDMA markedly increased under the experimental conditions used. By giving rats a copper deficient diet for a few days the increased incorporation of [3H]thymidine into liver DNA of rats treated with NDMA was enhanced compared to that of pair-fed rats treated with NDMA. The activity of thymidine kinase in liver of copper deficient rats treated with NDMA was also found to increase ingnificantly compared to that of pair-fed rats treated with NDMA.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>8508479</pmid><doi>10.1248/cpb.41.769</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Copper - deficiency Copper - metabolism Dimethylnitrosamine - pharmacology DNA - biosynthesis DNA - drug effects Liver - drug effects Liver - metabolism Male Medical sciences N-nitrosodimethylamine rat liver DNA synthesis Rats Rats, Wistar Thymidine Kinase - metabolism Tumors |
| title | Alteration of Hepatic DNA Synthesis in Rats Treated with N-Nitrosodimethylamine during Early Stages of Copper Deficiency |
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