Effect of O2 tension on the bioactivation and metabolism of aliphatic halides by primary rat-hepatocyte cultures

1. The covalent binding of CCl4 and CF3CHBrCl to cultured rat hepatocytes was enhanced by anoxic conditions, indicative of enhanced reductive biotransformation. 2. The covalent binding of CHCl3 and CHCl2CH2Cl decreased as the O2 concentration was decreased, indicating a preference for oxidative meta...

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Veröffentlicht in:	Xenobiotica 1984, Vol.14 (7), p.521-525
Hauptverfasser:	Direnzo, A. B., Gandolf, A. J., Sipes, I. G., Brendel, K., Byard, J. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotransformation Carbon Tetrachloride - metabolism Cells, Cultured Chemical and industrial products toxicology. Toxic occupational diseases Chloroform - metabolism Halothane - metabolism Hydrocarbons, Chlorinated - metabolism Kinetics Liver - drug effects Liver - metabolism Male Medical sciences Oxygen - pharmacology Rats Rats, Inbred Strains Toxicology Trichloroethanes - metabolism Various organic compounds
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