Sex- and tissue-specific, but hormonally independent, demethylation at the 3'-end of Xenopus vitellogenin gene B1
We describe three HpaII-specifying sequences in 6 kbp of DNA at the 3'-end of Xenopus vitellogenin gene B1 (two within the coding sequence and one downstream) which remain methylated in all tissues of adult male Xenopus. These sites are however fully demethylated exclusively in adult female Xen...
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| Veröffentlicht in: | FEBS letters 1984-12, Vol.178 (2), p.217-222 |
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| creator | Ng, Wee Chit Baker, Betty S. Tata, Jamshed R. |
| description | We describe three
HpaII-specifying sequences in 6 kbp of DNA at the 3'-end of
Xenopus vitellogenin gene B1 (two within the coding sequence and one downstream) which remain methylated in all tissues of adult male
Xenopus. These sites are however fully demethylated exclusively in adult female
Xenopus liver parenchymal cells but not in oviduct, kidney or erythrocytes. Developmental studies suggest that this tissue- and sex-specific demethylation may occur gradually after metamorphosis. The methylation of these 3'-sites is independent of transcriptional activation by oestrogen of vitellogenin genes in male or female
Xenopus. |
| doi_str_mv | 10.1016/0014-5793(84)80604-3 |
| format | Article |
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HpaII-specifying sequences in 6 kbp of DNA at the 3'-end of
Xenopus vitellogenin gene B1 (two within the coding sequence and one downstream) which remain methylated in all tissues of adult male
Xenopus. These sites are however fully demethylated exclusively in adult female
Xenopus liver parenchymal cells but not in oviduct, kidney or erythrocytes. Developmental studies suggest that this tissue- and sex-specific demethylation may occur gradually after metamorphosis. The methylation of these 3'-sites is independent of transcriptional activation by oestrogen of vitellogenin genes in male or female
Xenopus.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(84)80604-3</identifier><identifier>PMID: 6096165</identifier><identifier>CODEN: FEBLAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; DNA - metabolism ; DNA methylation ; DNA Restriction Enzymes ; Erythrocytes - metabolism ; Estradiol - pharmacology ; Estrogen ; Female ; Fundamental and applied biological sciences. Psychology ; Genes. Genome ; Kidney - metabolism ; Lipoproteins - genetics ; Liver - metabolism ; Male ; Methylation ; Molecular and cellular biology ; Molecular genetics ; Oviducts - metabolism ; Sex Factors ; Sex-specificity ; Tissue-specificity ; Transcription, Genetic - drug effects ; Vitellogenin gene expression ; Vitellogenins - genetics ; Xenopus ; Xenopus - growth & development</subject><ispartof>FEBS letters, 1984-12, Vol.178 (2), p.217-222</ispartof><rights>1984</rights><rights>FEBS Letters 178 (1984) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4413-a650283b869767474df5f57afc117155ee3f0805e8e914a58a8caabf7ad689ab3</citedby><cites>FETCH-LOGICAL-c4413-a650283b869767474df5f57afc117155ee3f0805e8e914a58a8caabf7ad689ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-5793(84)80604-3$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9220617$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6096165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ng, Wee Chit</creatorcontrib><creatorcontrib>Baker, Betty S.</creatorcontrib><creatorcontrib>Tata, Jamshed R.</creatorcontrib><title>Sex- and tissue-specific, but hormonally independent, demethylation at the 3'-end of Xenopus vitellogenin gene B1</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>We describe three
HpaII-specifying sequences in 6 kbp of DNA at the 3'-end of
Xenopus vitellogenin gene B1 (two within the coding sequence and one downstream) which remain methylated in all tissues of adult male
Xenopus. These sites are however fully demethylated exclusively in adult female
Xenopus liver parenchymal cells but not in oviduct, kidney or erythrocytes. Developmental studies suggest that this tissue- and sex-specific demethylation may occur gradually after metamorphosis. The methylation of these 3'-sites is independent of transcriptional activation by oestrogen of vitellogenin genes in male or female
Xenopus.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>DNA - metabolism</subject><subject>DNA methylation</subject><subject>DNA Restriction Enzymes</subject><subject>Erythrocytes - metabolism</subject><subject>Estradiol - pharmacology</subject><subject>Estrogen</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes. Genome</subject><subject>Kidney - metabolism</subject><subject>Lipoproteins - genetics</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Methylation</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Oviducts - metabolism</subject><subject>Sex Factors</subject><subject>Sex-specificity</subject><subject>Tissue-specificity</subject><subject>Transcription, Genetic - drug effects</subject><subject>Vitellogenin gene expression</subject><subject>Vitellogenins - genetics</subject><subject>Xenopus</subject><subject>Xenopus - growth & development</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EKtvCPwDJB8SH1IAdf-aCRKsuIFXiAEjcLMcZs0ZZO42d0v33JN3VHoHLWJ738TvjGYSeUfKWEirfEUJ5JVTDXmv-RhNJeMUeoBXVilWMS_0QrY7IY3Sa8y8y3zVtTtCJJI2kUqzQzVe4q7CNHS4h5wmqPIALPrhz3E4Fb9K4TdH2_Q6H2MEAc4jlHHewhbLZ9baEFLEtuGwAs1fVrOPk8Q-IaZgyvg0F-j79hBginiPgC_oEPfK2z_D0cJ6h7-urb5efqusvHz9ffriuHOeUVVYKUmvWatkoqbjinRdeKOsdpYoKAcA80USAhoZyK7TVztrWK9tJ3diWnaGXe99hTDcT5GK2Ibu5HRshTdkooYlWNfsnSDmlNaV6BvkedGPKeQRvhjFs7bgzlJhlJWaZt1nmbTQ39ysxi__zg__UbqE7PjrsYNZfHHSbne39aKML-Yg1dU0kVTO23mO_Qw-7_ypt1lcX9SIsec3vs0s_7_dGME__NsBosgsQHXRhBFdMl8LfP_QHC8W6JQ</recordid><startdate>19841210</startdate><enddate>19841210</enddate><creator>Ng, Wee Chit</creator><creator>Baker, Betty S.</creator><creator>Tata, Jamshed R.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19841210</creationdate><title>Sex- and tissue-specific, but hormonally independent, demethylation at the 3'-end of Xenopus vitellogenin gene B1</title><author>Ng, Wee Chit ; Baker, Betty S. ; Tata, Jamshed R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4413-a650283b869767474df5f57afc117155ee3f0805e8e914a58a8caabf7ad689ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>DNA - metabolism</topic><topic>DNA methylation</topic><topic>DNA Restriction Enzymes</topic><topic>Erythrocytes - metabolism</topic><topic>Estradiol - pharmacology</topic><topic>Estrogen</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes. Genome</topic><topic>Kidney - metabolism</topic><topic>Lipoproteins - genetics</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Methylation</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Oviducts - metabolism</topic><topic>Sex Factors</topic><topic>Sex-specificity</topic><topic>Tissue-specificity</topic><topic>Transcription, Genetic - drug effects</topic><topic>Vitellogenin gene expression</topic><topic>Vitellogenins - genetics</topic><topic>Xenopus</topic><topic>Xenopus - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ng, Wee Chit</creatorcontrib><creatorcontrib>Baker, Betty S.</creatorcontrib><creatorcontrib>Tata, Jamshed R.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ng, Wee Chit</au><au>Baker, Betty S.</au><au>Tata, Jamshed R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex- and tissue-specific, but hormonally independent, demethylation at the 3'-end of Xenopus vitellogenin gene B1</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1984-12-10</date><risdate>1984</risdate><volume>178</volume><issue>2</issue><spage>217</spage><epage>222</epage><pages>217-222</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>We describe three
HpaII-specifying sequences in 6 kbp of DNA at the 3'-end of
Xenopus vitellogenin gene B1 (two within the coding sequence and one downstream) which remain methylated in all tissues of adult male
Xenopus. These sites are however fully demethylated exclusively in adult female
Xenopus liver parenchymal cells but not in oviduct, kidney or erythrocytes. Developmental studies suggest that this tissue- and sex-specific demethylation may occur gradually after metamorphosis. The methylation of these 3'-sites is independent of transcriptional activation by oestrogen of vitellogenin genes in male or female
Xenopus.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>6096165</pmid><doi>10.1016/0014-5793(84)80604-3</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEBS letters, 1984-12, Vol.178 (2), p.217-222 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier); Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences DNA - metabolism DNA methylation DNA Restriction Enzymes Erythrocytes - metabolism Estradiol - pharmacology Estrogen Female Fundamental and applied biological sciences. Psychology Genes. Genome Kidney - metabolism Lipoproteins - genetics Liver - metabolism Male Methylation Molecular and cellular biology Molecular genetics Oviducts - metabolism Sex Factors Sex-specificity Tissue-specificity Transcription, Genetic - drug effects Vitellogenin gene expression Vitellogenins - genetics Xenopus Xenopus - growth & development |
| title | Sex- and tissue-specific, but hormonally independent, demethylation at the 3'-end of Xenopus vitellogenin gene B1 |
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