Pharmacokinetic measurement of drugs in lung epithelial lining fluid by microdialysis: Aminoglycoside antibiotics in rat bronchi

A novel technique for in vivo intrabronchial pharmacokinetic measurements using microdialysis is described. The technique was applied to the measurement of tobramycin and gentamicin in the anesthetized rat. The concentration versus time profiles of the drugs in the lung epithelial lining fluid (ELF)...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 1993-04, Vol.29 (2), p.93-98
Hauptverfasser:	Eisenberg, Eugene J., Conzentino, Phil, Eickhoff, W.Mark, Cundy, Kenneth C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bronchoalveolar Lavage Fluid - metabolism Chromatography, High Pressure Liquid Dialysis Epithelial lining fluid Epithelium - metabolism Gentamicin Gentamicins - pharmacokinetics Lung Lung - metabolism Male Microdialysis Pharmacokinetics Rats Rats, Sprague-Dawley Tobramycin Tobramycin - pharmacokinetics
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