Resistance of MHC Class I-Deficient Mice to Experimental Systemic Lupus Erythematosus

Experimental systemic lupus erythematosus (SLE) can be induced in mice by immunization with a human monoclonal antibody to DNA that bears a common idiotype (16/6Id). These mice generate antibodies to 16/6Id, antibodies to DNA, and antibodies directed against nuclear antigens. Subsequently, manifesta...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1993-07, Vol.261 (5117), p.91-93
Hauptverfasser:	Mozes, Edna, Kohn, Leonard D., Hakim, Fran, Singer, Dinah S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Antinuclear - immunology Antibodies, Monoclonal - immunology Antigens Biological and medical sciences DNA Experimental and animal immunopathology. Animal models Histocompatibility Antigens Class I - immunology Immunity, Innate Immunization Immunoglobulin Idiotypes - immunology Immunopathology Kidneys Lupus Erythematosus, Systemic - immunology Medical sciences Mice Nuclear antigens Systemic lupus erythematosus T lymphocytes Titration
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