Resistance of MHC Class I-Deficient Mice to Experimental Systemic Lupus Erythematosus

Experimental systemic lupus erythematosus (SLE) can be induced in mice by immunization with a human monoclonal antibody to DNA that bears a common idiotype (16/6Id). These mice generate antibodies to 16/6Id, antibodies to DNA, and antibodies directed against nuclear antigens. Subsequently, manifesta...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Science (American Association for the Advancement of Science) 1993-07, Vol.261 (5117), p.91-93
Hauptverfasser: Mozes, Edna, Kohn, Leonard D., Hakim, Fran, Singer, Dinah S.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 93
container_issue 5117
container_start_page 91
container_title Science (American Association for the Advancement of Science)
container_volume 261
creator Mozes, Edna
Kohn, Leonard D.
Hakim, Fran
Singer, Dinah S.
description Experimental systemic lupus erythematosus (SLE) can be induced in mice by immunization with a human monoclonal antibody to DNA that bears a common idiotype (16/6Id). These mice generate antibodies to 16/6Id, antibodies to DNA, and antibodies directed against nuclear antigens. Subsequently, manifestations of SLE develop, including leukopenia, proteinuria, and immune complex deposits in the kidney. In contrast, after immunization with 16/6Id, mice lacking major histocompatibility complex (MHC) class I molecules generated antibodies to 16/6Id but did not generate antibodies to DNA or to nuclear antigen. Furthermore, they did not develop any of the above clinical manifestations. These results reveal an unexpected function of MHC class I in the induction of autoimmune SLE.
doi_str_mv 10.1126/science.8316860
format Article
fullrecord <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_75806076</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>2881472</jstor_id><sourcerecordid>2881472</sourcerecordid><originalsourceid>FETCH-LOGICAL-c468t-3dfb7b8ec8e91cfd0d8e1185e4d0db96efe95c3f14d44b5c7e4c649ac2b63fc43</originalsourceid><addsrcrecordid>eNqFkMFLwzAUh4MoOqdnLwo5iLe6pEnT9ChzOmFDUHcuafqClXadfSm4_96MlXn0lEe-7_1CfoRccXbPeawmaCtYW7jXgiut2BEZcZYlURYzcUxGjAkVaZYmZ-Qc8YuxwDJxSk4HfURWb4AVehMyaOvocj6l09og0pfoEVy1S_d0WQXqWzr72UBXNeHK1PR9ix6aytJFv-mRzrqt_4TG-BZ7vCAnztQIl8M5Jqun2cd0Hi1en1-mD4vISqV9JEpXpIUGqyHj1pWs1MC5TkCGscgUOMgSKxyXpZRFYlOQVsnM2LhQwlkpxuRun7vp2u8e0OdNhRbq2qyh7TFPE80US9W_IldKapGxIE72ou1axA5cvgk_Nt025yzfNZ4PjedDhWHjZojuiwbKg__Hbwdu0JradaHrCg9aeJapJA3a9V77Qt92BxxrzWUai18EQJSW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16648390</pqid></control><display><type>article</type><title>Resistance of MHC Class I-Deficient Mice to Experimental Systemic Lupus Erythematosus</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>American Association for the Advancement of Science</source><creator>Mozes, Edna ; Kohn, Leonard D. ; Hakim, Fran ; Singer, Dinah S.</creator><creatorcontrib>Mozes, Edna ; Kohn, Leonard D. ; Hakim, Fran ; Singer, Dinah S.</creatorcontrib><description>Experimental systemic lupus erythematosus (SLE) can be induced in mice by immunization with a human monoclonal antibody to DNA that bears a common idiotype (16/6Id). These mice generate antibodies to 16/6Id, antibodies to DNA, and antibodies directed against nuclear antigens. Subsequently, manifestations of SLE develop, including leukopenia, proteinuria, and immune complex deposits in the kidney. In contrast, after immunization with 16/6Id, mice lacking major histocompatibility complex (MHC) class I molecules generated antibodies to 16/6Id but did not generate antibodies to DNA or to nuclear antigen. Furthermore, they did not develop any of the above clinical manifestations. These results reveal an unexpected function of MHC class I in the induction of autoimmune SLE.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.8316860</identifier><identifier>PMID: 8316860</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Animals ; Antibodies ; Antibodies, Antinuclear - immunology ; Antibodies, Monoclonal - immunology ; Antigens ; Biological and medical sciences ; DNA ; Experimental and animal immunopathology. Animal models ; Histocompatibility Antigens Class I - immunology ; Immunity, Innate ; Immunization ; Immunoglobulin Idiotypes - immunology ; Immunopathology ; Kidneys ; Lupus Erythematosus, Systemic - immunology ; Medical sciences ; Mice ; Nuclear antigens ; Systemic lupus erythematosus ; T lymphocytes ; Titration</subject><ispartof>Science (American Association for the Advancement of Science), 1993-07, Vol.261 (5117), p.91-93</ispartof><rights>Copyright 1993 American Association for the Advancement of Science</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-3dfb7b8ec8e91cfd0d8e1185e4d0db96efe95c3f14d44b5c7e4c649ac2b63fc43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2881472$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2881472$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=4830657$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8316860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mozes, Edna</creatorcontrib><creatorcontrib>Kohn, Leonard D.</creatorcontrib><creatorcontrib>Hakim, Fran</creatorcontrib><creatorcontrib>Singer, Dinah S.</creatorcontrib><title>Resistance of MHC Class I-Deficient Mice to Experimental Systemic Lupus Erythematosus</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Experimental systemic lupus erythematosus (SLE) can be induced in mice by immunization with a human monoclonal antibody to DNA that bears a common idiotype (16/6Id). These mice generate antibodies to 16/6Id, antibodies to DNA, and antibodies directed against nuclear antigens. Subsequently, manifestations of SLE develop, including leukopenia, proteinuria, and immune complex deposits in the kidney. In contrast, after immunization with 16/6Id, mice lacking major histocompatibility complex (MHC) class I molecules generated antibodies to 16/6Id but did not generate antibodies to DNA or to nuclear antigen. Furthermore, they did not develop any of the above clinical manifestations. These results reveal an unexpected function of MHC class I in the induction of autoimmune SLE.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Antinuclear - immunology</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>DNA</subject><subject>Experimental and animal immunopathology. Animal models</subject><subject>Histocompatibility Antigens Class I - immunology</subject><subject>Immunity, Innate</subject><subject>Immunization</subject><subject>Immunoglobulin Idiotypes - immunology</subject><subject>Immunopathology</subject><subject>Kidneys</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Nuclear antigens</subject><subject>Systemic lupus erythematosus</subject><subject>T lymphocytes</subject><subject>Titration</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFLwzAUh4MoOqdnLwo5iLe6pEnT9ChzOmFDUHcuafqClXadfSm4_96MlXn0lEe-7_1CfoRccXbPeawmaCtYW7jXgiut2BEZcZYlURYzcUxGjAkVaZYmZ-Qc8YuxwDJxSk4HfURWb4AVehMyaOvocj6l09og0pfoEVy1S_d0WQXqWzr72UBXNeHK1PR9ix6aytJFv-mRzrqt_4TG-BZ7vCAnztQIl8M5Jqun2cd0Hi1en1-mD4vISqV9JEpXpIUGqyHj1pWs1MC5TkCGscgUOMgSKxyXpZRFYlOQVsnM2LhQwlkpxuRun7vp2u8e0OdNhRbq2qyh7TFPE80US9W_IldKapGxIE72ou1axA5cvgk_Nt025yzfNZ4PjedDhWHjZojuiwbKg__Hbwdu0JradaHrCg9aeJapJA3a9V77Qt92BxxrzWUai18EQJSW</recordid><startdate>19930702</startdate><enddate>19930702</enddate><creator>Mozes, Edna</creator><creator>Kohn, Leonard D.</creator><creator>Hakim, Fran</creator><creator>Singer, Dinah S.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19930702</creationdate><title>Resistance of MHC Class I-Deficient Mice to Experimental Systemic Lupus Erythematosus</title><author>Mozes, Edna ; Kohn, Leonard D. ; Hakim, Fran ; Singer, Dinah S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-3dfb7b8ec8e91cfd0d8e1185e4d0db96efe95c3f14d44b5c7e4c649ac2b63fc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Antinuclear - immunology</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antigens</topic><topic>Biological and medical sciences</topic><topic>DNA</topic><topic>Experimental and animal immunopathology. Animal models</topic><topic>Histocompatibility Antigens Class I - immunology</topic><topic>Immunity, Innate</topic><topic>Immunization</topic><topic>Immunoglobulin Idiotypes - immunology</topic><topic>Immunopathology</topic><topic>Kidneys</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Nuclear antigens</topic><topic>Systemic lupus erythematosus</topic><topic>T lymphocytes</topic><topic>Titration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mozes, Edna</creatorcontrib><creatorcontrib>Kohn, Leonard D.</creatorcontrib><creatorcontrib>Hakim, Fran</creatorcontrib><creatorcontrib>Singer, Dinah S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mozes, Edna</au><au>Kohn, Leonard D.</au><au>Hakim, Fran</au><au>Singer, Dinah S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resistance of MHC Class I-Deficient Mice to Experimental Systemic Lupus Erythematosus</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1993-07-02</date><risdate>1993</risdate><volume>261</volume><issue>5117</issue><spage>91</spage><epage>93</epage><pages>91-93</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Experimental systemic lupus erythematosus (SLE) can be induced in mice by immunization with a human monoclonal antibody to DNA that bears a common idiotype (16/6Id). These mice generate antibodies to 16/6Id, antibodies to DNA, and antibodies directed against nuclear antigens. Subsequently, manifestations of SLE develop, including leukopenia, proteinuria, and immune complex deposits in the kidney. In contrast, after immunization with 16/6Id, mice lacking major histocompatibility complex (MHC) class I molecules generated antibodies to 16/6Id but did not generate antibodies to DNA or to nuclear antigen. Furthermore, they did not develop any of the above clinical manifestations. These results reveal an unexpected function of MHC class I in the induction of autoimmune SLE.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8316860</pmid><doi>10.1126/science.8316860</doi><tpages>3</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0036-8075
ispartof Science (American Association for the Advancement of Science), 1993-07, Vol.261 (5117), p.91-93
issn 0036-8075
1095-9203
language eng
recordid cdi_proquest_miscellaneous_75806076
source MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science
subjects Animals
Antibodies
Antibodies, Antinuclear - immunology
Antibodies, Monoclonal - immunology
Antigens
Biological and medical sciences
DNA
Experimental and animal immunopathology. Animal models
Histocompatibility Antigens Class I - immunology
Immunity, Innate
Immunization
Immunoglobulin Idiotypes - immunology
Immunopathology
Kidneys
Lupus Erythematosus, Systemic - immunology
Medical sciences
Mice
Nuclear antigens
Systemic lupus erythematosus
T lymphocytes
Titration
title Resistance of MHC Class I-Deficient Mice to Experimental Systemic Lupus Erythematosus
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T10%3A11%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Resistance%20of%20MHC%20Class%20I-Deficient%20Mice%20to%20Experimental%20Systemic%20Lupus%20Erythematosus&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Mozes,%20Edna&rft.date=1993-07-02&rft.volume=261&rft.issue=5117&rft.spage=91&rft.epage=93&rft.pages=91-93&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.8316860&rft_dat=%3Cjstor_proqu%3E2881472%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16648390&rft_id=info:pmid/8316860&rft_jstor_id=2881472&rfr_iscdi=true