Retinal Dopamine and its Metabolite Contents in Zitter Rats and Spontaneously Epileptic Rats
In order to investigate the relationship between visual dysfunction and retinal DA metabolism in zitter rats and spontaneously epileptic rats (SER), we measured the amounts of retinal dopamine (DA) and its metabolites, 3, 4-dihydroxyphenylacetic acid (DOPAC) and homovanillate (HVA) . DA, DOPAC and H...
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| Veröffentlicht in: | Experimental Animals 1993/04/01, Vol.42(2), pp.249-250 |
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| creator | KOBAYASHI, Kinji KAWASHIMA, Kazutaka KAWASHIMA, Yumiko YAMAMURA, Takaaki KUSE, Hiroshi ASANO, Yuzo KAWAI, Yoshiaki HORI, Masaki OKANIWA, Azusa SERIKAWA, Tadao YAMADA, Junzo |
| description | In order to investigate the relationship between visual dysfunction and retinal DA metabolism in zitter rats and spontaneously epileptic rats (SER), we measured the amounts of retinal dopamine (DA) and its metabolites, 3, 4-dihydroxyphenylacetic acid (DOPAC) and homovanillate (HVA) . DA, DOPAC and HVA contents were markedly decreased in zitter rats as compared with the controls, Kyo: Wistar or Sprague-Dawley rats. In contrast, in SER, retinal DA and its metabolite contents were not significantly different from those of Kyo: Wistar rats. SER showed higher levels of DA and its metabolites in comparison with Sprague-Dawley rats. Thus, it is suggested that the debilitation of retinal DA synthesis is at least partly related to the visual dysfunction observed in zitter rats, but not that of SER. |
| doi_str_mv | 10.1538/expanim1978.42.2_249 |
| format | Article |
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DA, DOPAC and HVA contents were markedly decreased in zitter rats as compared with the controls, Kyo: Wistar or Sprague-Dawley rats. In contrast, in SER, retinal DA and its metabolite contents were not significantly different from those of Kyo: Wistar rats. SER showed higher levels of DA and its metabolites in comparison with Sprague-Dawley rats. Thus, it is suggested that the debilitation of retinal DA synthesis is at least partly related to the visual dysfunction observed in zitter rats, but not that of SER.</description><identifier>ISSN: 0007-5124</identifier><identifier>EISSN: 1881-7122</identifier><identifier>DOI: 10.1538/expanim1978.42.2_249</identifier><identifier>PMID: 8519304</identifier><language>eng</language><publisher>Japan: Japanese Association for Laboratory Animal Science</publisher><subject>3,4-Dihydroxyphenylacetic Acid - analysis ; Animals ; dopamine ; Dopamine - metabolism ; Epilepsy - metabolism ; Homovanillic Acid - analysis ; Male ; Rats ; Rats, Inbred WKY ; Rats, Sprague-Dawley ; retina ; Retina - metabolism ; spontaneously epileptic rats ; Vision Disorders - metabolism ; visual dysfunction</subject><ispartof>Experimental Animals, 1993/04/01, Vol.42(2), pp.249-250</ispartof><rights>Japanese Association for Laboratory Animal Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8519304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOBAYASHI, Kinji</creatorcontrib><creatorcontrib>KAWASHIMA, Kazutaka</creatorcontrib><creatorcontrib>KAWASHIMA, Yumiko</creatorcontrib><creatorcontrib>YAMAMURA, Takaaki</creatorcontrib><creatorcontrib>KUSE, Hiroshi</creatorcontrib><creatorcontrib>ASANO, Yuzo</creatorcontrib><creatorcontrib>KAWAI, Yoshiaki</creatorcontrib><creatorcontrib>HORI, Masaki</creatorcontrib><creatorcontrib>OKANIWA, Azusa</creatorcontrib><creatorcontrib>SERIKAWA, Tadao</creatorcontrib><creatorcontrib>YAMADA, Junzo</creatorcontrib><title>Retinal Dopamine and its Metabolite Contents in Zitter Rats and Spontaneously Epileptic Rats</title><title>Experimental Animals</title><addtitle>Experimental Animals</addtitle><description>In order to investigate the relationship between visual dysfunction and retinal DA metabolism in zitter rats and spontaneously epileptic rats (SER), we measured the amounts of retinal dopamine (DA) and its metabolites, 3, 4-dihydroxyphenylacetic acid (DOPAC) and homovanillate (HVA) . DA, DOPAC and HVA contents were markedly decreased in zitter rats as compared with the controls, Kyo: Wistar or Sprague-Dawley rats. In contrast, in SER, retinal DA and its metabolite contents were not significantly different from those of Kyo: Wistar rats. SER showed higher levels of DA and its metabolites in comparison with Sprague-Dawley rats. Thus, it is suggested that the debilitation of retinal DA synthesis is at least partly related to the visual dysfunction observed in zitter rats, but not that of SER.</description><subject>3,4-Dihydroxyphenylacetic Acid - analysis</subject><subject>Animals</subject><subject>dopamine</subject><subject>Dopamine - metabolism</subject><subject>Epilepsy - metabolism</subject><subject>Homovanillic Acid - analysis</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred WKY</subject><subject>Rats, Sprague-Dawley</subject><subject>retina</subject><subject>Retina - metabolism</subject><subject>spontaneously epileptic rats</subject><subject>Vision Disorders - metabolism</subject><subject>visual dysfunction</subject><issn>0007-5124</issn><issn>1881-7122</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkE1LAzEURYMoWqr_QGFW7qYmmaRJllI_QRH82IgQ0syLRmYy4yQF_femthbBVXi59x0eB6FDgieEV_IEPnsTfEuUkBNGJ1RTprbQiEhJSkEo3UYjjLEoOaFsDx3E-J5HrAgmgu-iXcmJqjAboZd7SD6YpjjretP6AIUJdeFTLG4hmXnX-ATFrAsJQv7zoXj2KcFQ3Js8LqsPfQ5NgG4Rm6_ivPcN9Mnbn8I-2nGmiXCwfsfo6eL8cXZV3txdXs9Ob0pbTUkqmSAKhJRK2royxFjHOK-xFVQpN6WAuRSWToFXQBxRHJhz8zkTBnDtpuCqMTpecfuh-1hATLr10ULTrO7SgsvMyN7GiK2KduhiHMDpfvCtGb40wXrpVf_xqlm2uvSa147W_MW8hXqztLaY88tV_h6TeYVNboZsooH_0F_ypmHfzKAhVN-mnZBs</recordid><startdate>19930401</startdate><enddate>19930401</enddate><creator>KOBAYASHI, Kinji</creator><creator>KAWASHIMA, Kazutaka</creator><creator>KAWASHIMA, Yumiko</creator><creator>YAMAMURA, Takaaki</creator><creator>KUSE, Hiroshi</creator><creator>ASANO, Yuzo</creator><creator>KAWAI, Yoshiaki</creator><creator>HORI, Masaki</creator><creator>OKANIWA, Azusa</creator><creator>SERIKAWA, Tadao</creator><creator>YAMADA, Junzo</creator><general>Japanese Association for Laboratory Animal Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930401</creationdate><title>Retinal Dopamine and its Metabolite Contents in Zitter Rats and Spontaneously Epileptic Rats</title><author>KOBAYASHI, Kinji ; KAWASHIMA, Kazutaka ; KAWASHIMA, Yumiko ; YAMAMURA, Takaaki ; KUSE, Hiroshi ; ASANO, Yuzo ; KAWAI, Yoshiaki ; HORI, Masaki ; OKANIWA, Azusa ; SERIKAWA, Tadao ; YAMADA, Junzo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-4719e78898cd3a1acf455d0c7299f62e0587c26e53e1f195e4ffbb47ae0df6ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>3,4-Dihydroxyphenylacetic Acid - analysis</topic><topic>Animals</topic><topic>dopamine</topic><topic>Dopamine - metabolism</topic><topic>Epilepsy - metabolism</topic><topic>Homovanillic Acid - analysis</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred WKY</topic><topic>Rats, Sprague-Dawley</topic><topic>retina</topic><topic>Retina - metabolism</topic><topic>spontaneously epileptic rats</topic><topic>Vision Disorders - metabolism</topic><topic>visual dysfunction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOBAYASHI, Kinji</creatorcontrib><creatorcontrib>KAWASHIMA, Kazutaka</creatorcontrib><creatorcontrib>KAWASHIMA, Yumiko</creatorcontrib><creatorcontrib>YAMAMURA, Takaaki</creatorcontrib><creatorcontrib>KUSE, Hiroshi</creatorcontrib><creatorcontrib>ASANO, Yuzo</creatorcontrib><creatorcontrib>KAWAI, Yoshiaki</creatorcontrib><creatorcontrib>HORI, Masaki</creatorcontrib><creatorcontrib>OKANIWA, Azusa</creatorcontrib><creatorcontrib>SERIKAWA, Tadao</creatorcontrib><creatorcontrib>YAMADA, Junzo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental Animals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOBAYASHI, Kinji</au><au>KAWASHIMA, Kazutaka</au><au>KAWASHIMA, Yumiko</au><au>YAMAMURA, Takaaki</au><au>KUSE, Hiroshi</au><au>ASANO, Yuzo</au><au>KAWAI, Yoshiaki</au><au>HORI, Masaki</au><au>OKANIWA, Azusa</au><au>SERIKAWA, Tadao</au><au>YAMADA, Junzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal Dopamine and its Metabolite Contents in Zitter Rats and Spontaneously Epileptic Rats</atitle><jtitle>Experimental Animals</jtitle><addtitle>Experimental Animals</addtitle><date>1993-04-01</date><risdate>1993</risdate><volume>42</volume><issue>2</issue><spage>249</spage><epage>250</epage><pages>249-250</pages><issn>0007-5124</issn><eissn>1881-7122</eissn><abstract>In order to investigate the relationship between visual dysfunction and retinal DA metabolism in zitter rats and spontaneously epileptic rats (SER), we measured the amounts of retinal dopamine (DA) and its metabolites, 3, 4-dihydroxyphenylacetic acid (DOPAC) and homovanillate (HVA) . DA, DOPAC and HVA contents were markedly decreased in zitter rats as compared with the controls, Kyo: Wistar or Sprague-Dawley rats. In contrast, in SER, retinal DA and its metabolite contents were not significantly different from those of Kyo: Wistar rats. SER showed higher levels of DA and its metabolites in comparison with Sprague-Dawley rats. Thus, it is suggested that the debilitation of retinal DA synthesis is at least partly related to the visual dysfunction observed in zitter rats, but not that of SER.</abstract><cop>Japan</cop><pub>Japanese Association for Laboratory Animal Science</pub><pmid>8519304</pmid><doi>10.1538/expanim1978.42.2_249</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Experimental Animals, 1993/04/01, Vol.42(2), pp.249-250 |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | 3,4-Dihydroxyphenylacetic Acid - analysis Animals dopamine Dopamine - metabolism Epilepsy - metabolism Homovanillic Acid - analysis Male Rats Rats, Inbred WKY Rats, Sprague-Dawley retina Retina - metabolism spontaneously epileptic rats Vision Disorders - metabolism visual dysfunction |
| title | Retinal Dopamine and its Metabolite Contents in Zitter Rats and Spontaneously Epileptic Rats |
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