Independent divergences in the CD4 binding site and V3 loop encoded in two seroprevalent Ugandan HIV-1 clinical isolates

Two major epitopes expressed in HIV-1 have been recently shown to play a central role in virus neutralization. One of these important specificities is a type-specific or group-specific, principal neutralizing determinant (PND) located in the V3 loop of gp120. The other is a more broadly neutralizing...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1988) 1993-08, Vol.6 (8), p.872-880
Hauptverfasser:	PESTANO, G, PRINCE, A, GUYDEN, J, NTAMBI, J. M, ATKIN, A, BOTO, W. M. O
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Base Sequence Binding Sites Biological and medical sciences CD4 Antigens - chemistry CD4 Antigens - genetics CD4 Antigens - immunology Cloning, Molecular Cohort Studies Cross Reactions DNA, Viral - chemistry Epitopes - chemistry Epitopes - genetics Epitopes - immunology Genetic Variation HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV Infections - microbiology HIV-1 - classification HIV-1 - genetics HIV-1 - immunology Humans Immune Sera - immunology Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Male Medical sciences Molecular Sequence Data Neutralization Tests New York City Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - immunology Phylogeny Protein Structure, Secondary Software Tropical medicine Uganda
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