Activated Expression of the N-myc Gene in Human Neuroblastomas and Related Tumors

In neuroblastoma lines in which the N-myc gene is present as a single copy, the expression of N-myc as messenger RNA is increased relative to that in nonneuroblastoma cell lines and tumors. The increase of expression in neuroblastomas with amplified N-myc genes is the result of (i) an increase in th...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1984-12, Vol.226 (4680), p.1335-1337
Hauptverfasser:	Kohl, Nancy E., Gee, Connie E., Alt, Frederick W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cancer Cancer research Cell Line Cell lines Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Fundamental and applied biological sciences. Psychology Gene Amplification Gene expression Gene Expression Regulation Genes Genetic aspects Humans Messenger RNA Molecular and cellular biology Molecular genetics myc genes Neuroblastoma Neuroblastoma - genetics Neuroendocrine carcinoma Oncogenes Oncology Oncology, Experimental RNA RNA probes RNA, Messenger - metabolism Tumor cell line Tumors
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