Identification and Cloning of a Protein Kinase-Encoding Mouse Gene, Plk, Related to the Polo Gene of Drosophila
We have determined the nucleotide sequence of a cDNA encoding a protein kinase that is closely related to the enzyme encoded by the Drosophila melanogaster mutant polo and that we have designated Plk (polo-like kinase). Plk is also related to the products of the Saccharomyces cerevisiae cell cycle g...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1993-06, Vol.90 (11), p.4882-4886 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Clay, Fiona J. McEwen, Stephen J. Bertoncello, Ivan Wilks, Andrew F. Dunn, Ashley R. |
| description | We have determined the nucleotide sequence of a cDNA encoding a protein kinase that is closely related to the enzyme encoded by the Drosophila melanogaster mutant polo and that we have designated Plk (polo-like kinase). Plk is also related to the products of the Saccharomyces cerevisiae cell cycle gene MSD2 (CDC5) and the recently described early growth response gene Snk. Together, Plk, polo, Snk, and MSD2 define a subfamily of serine/threonine protein kinases. Plk is expressed at high levels in a number of fetal and newborn mouse tissues but is not expressed in the corresponding adult organs. With the exception of adult hemopoietic tissues, the only adult tissues in which we could detect Plk expression were ovaries and testes. Taken together, the patterns of Plk expression suggest an association with proliferating cells. Since polo is required for mitosis in Drosophila it is possible that Plk is involved in some aspect of cell cycle regulation in mammalian cells. |
| doi_str_mv | 10.1073/pnas.90.11.4882 |
| format | Article |
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Plk is also related to the products of the Saccharomyces cerevisiae cell cycle gene MSD2 (CDC5) and the recently described early growth response gene Snk. Together, Plk, polo, Snk, and MSD2 define a subfamily of serine/threonine protein kinases. Plk is expressed at high levels in a number of fetal and newborn mouse tissues but is not expressed in the corresponding adult organs. With the exception of adult hemopoietic tissues, the only adult tissues in which we could detect Plk expression were ovaries and testes. Taken together, the patterns of Plk expression suggest an association with proliferating cells. Since polo is required for mitosis in Drosophila it is possible that Plk is involved in some aspect of cell cycle regulation in mammalian cells.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.90.11.4882</identifier><identifier>PMID: 8099445</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Amino Acid Sequence ; Amino acids ; Analytical, structural and metabolic biochemistry ; Animals ; Base Sequence ; Biological and medical sciences ; Blotting, Northern ; Bone Marrow - enzymology ; Brain - enzymology ; Cellular biology ; Cloning, Molecular ; Complementary DNA ; DNA - genetics ; DNA - isolation & purification ; Drosophila ; Drosophila melanogaster - enzymology ; Drosophila melanogaster - genetics ; Enzymes and enzyme inhibitors ; Fetus ; Fundamental and applied biological sciences. Psychology ; Genetics ; Hematopoietic Stem Cells - enzymology ; Liver - enzymology ; Messenger RNA ; Mice ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Molecular Sequence Data ; Nucleotide sequences ; Oligodeoxyribonucleotides ; Oligonucleotides, Antisense ; Organ Specificity ; Ovaries ; Phylogeny ; Poly A - genetics ; Poly A - isolation & purification ; Polymerase Chain Reaction ; Protein Kinases - genetics ; Protein-Serine-Threonine Kinases - genetics ; Proteins ; Restriction Mapping ; RNA, Messenger - genetics ; RNA, Messenger - isolation & purification ; Sequence Homology, Amino Acid ; Testes ; Transferases</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1993-06, Vol.90 (11), p.4882-4886</ispartof><rights>Copyright 1993 The National Academy of Sciences of the United States of America</rights><rights>1993 INIST-CNRS</rights><rights>Copyright National Academy of Sciences Jun 1, 1993</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-8c282ffaf0b9061b499195e653f89079d3ba2e0520688aca6198470d7f2d903b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/90/11.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2362185$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2362185$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27923,27924,53790,53792,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4827766$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8099445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Clay, Fiona J.</creatorcontrib><creatorcontrib>McEwen, Stephen J.</creatorcontrib><creatorcontrib>Bertoncello, Ivan</creatorcontrib><creatorcontrib>Wilks, Andrew F.</creatorcontrib><creatorcontrib>Dunn, Ashley R.</creatorcontrib><title>Identification and Cloning of a Protein Kinase-Encoding Mouse Gene, Plk, Related to the Polo Gene of Drosophila</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>We have determined the nucleotide sequence of a cDNA encoding a protein kinase that is closely related to the enzyme encoded by the Drosophila melanogaster mutant polo and that we have designated Plk (polo-like kinase). Plk is also related to the products of the Saccharomyces cerevisiae cell cycle gene MSD2 (CDC5) and the recently described early growth response gene Snk. Together, Plk, polo, Snk, and MSD2 define a subfamily of serine/threonine protein kinases. Plk is expressed at high levels in a number of fetal and newborn mouse tissues but is not expressed in the corresponding adult organs. With the exception of adult hemopoietic tissues, the only adult tissues in which we could detect Plk expression were ovaries and testes. Taken together, the patterns of Plk expression suggest an association with proliferating cells. Since polo is required for mitosis in Drosophila it is possible that Plk is involved in some aspect of cell cycle regulation in mammalian cells.</description><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Bone Marrow - enzymology</subject><subject>Brain - enzymology</subject><subject>Cellular biology</subject><subject>Cloning, Molecular</subject><subject>Complementary DNA</subject><subject>DNA - genetics</subject><subject>DNA - isolation & purification</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - enzymology</subject><subject>Drosophila melanogaster - genetics</subject><subject>Enzymes and enzyme inhibitors</subject><subject>Fetus</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics</subject><subject>Hematopoietic Stem Cells - enzymology</subject><subject>Liver - enzymology</subject><subject>Messenger RNA</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred ICR</subject><subject>Molecular Sequence Data</subject><subject>Nucleotide sequences</subject><subject>Oligodeoxyribonucleotides</subject><subject>Oligonucleotides, Antisense</subject><subject>Organ Specificity</subject><subject>Ovaries</subject><subject>Phylogeny</subject><subject>Poly A - genetics</subject><subject>Poly A - isolation & purification</subject><subject>Polymerase Chain Reaction</subject><subject>Protein Kinases - genetics</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Proteins</subject><subject>Restriction Mapping</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - isolation & purification</subject><subject>Sequence Homology, Amino Acid</subject><subject>Testes</subject><subject>Transferases</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhSMEKkvhzAWQhSq4NNux4zi2xAUtpVQUsUJwtryJ3fXitZfYQeXf47BhRTnAyRq9b2Y87xXFYwxzDE11tvMqzkUu8JxyTu4UMwwCl4wKuFvMAEhTckro_eJBjBsAEDWHo-KIgxCU1rMiXHbaJ2tsq5INHinfoYUL3vprFAxSaNmHpK1H723epMtz34ZuFD-EIWp0ob0-RUv39RR90k4l3aEUUFprtAwu_JLHMW_6EMNubZ16WNwzykX9aHqPiy9vzz8v3pVXHy8uF6-vyramIpW8JZwYowysBDC8okJgUWtWV4YLaERXrRTRUBNgnKtWMSw4baBrDOkEVKvquHi1n7sbVlvdtfnIXjm56-1W9T9kUFbeVrxdy-vwXVLGcJPbX0ztffg26Jjk1sZWO6e8zofLJttIgJP_gpgxghsyTnz-F7gJQ--zB5IAJoySimbobA-12bDYa3P4MAY55i3HvKXIBZZj3rnj6Z93Hvgp4KyfTLqKrXKmV7618YBRTpqGsYw9m7Bx_m_11p6X_wSkGZxL-iZl8sme3MQU-gNKqmwEr6ufK4zTwA</recordid><startdate>19930601</startdate><enddate>19930601</enddate><creator>Clay, Fiona J.</creator><creator>McEwen, Stephen J.</creator><creator>Bertoncello, Ivan</creator><creator>Wilks, Andrew F.</creator><creator>Dunn, Ashley R.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19930601</creationdate><title>Identification and Cloning of a Protein Kinase-Encoding Mouse Gene, Plk, Related to the Polo Gene of Drosophila</title><author>Clay, Fiona J. ; McEwen, Stephen J. ; Bertoncello, Ivan ; Wilks, Andrew F. ; Dunn, Ashley R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-8c282ffaf0b9061b499195e653f89079d3ba2e0520688aca6198470d7f2d903b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Bone Marrow - enzymology</topic><topic>Brain - enzymology</topic><topic>Cellular biology</topic><topic>Cloning, Molecular</topic><topic>Complementary DNA</topic><topic>DNA - genetics</topic><topic>DNA - isolation & purification</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - enzymology</topic><topic>Drosophila melanogaster - genetics</topic><topic>Enzymes and enzyme inhibitors</topic><topic>Fetus</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics</topic><topic>Hematopoietic Stem Cells - enzymology</topic><topic>Liver - enzymology</topic><topic>Messenger RNA</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred ICR</topic><topic>Molecular Sequence Data</topic><topic>Nucleotide sequences</topic><topic>Oligodeoxyribonucleotides</topic><topic>Oligonucleotides, Antisense</topic><topic>Organ Specificity</topic><topic>Ovaries</topic><topic>Phylogeny</topic><topic>Poly A - genetics</topic><topic>Poly A - isolation & purification</topic><topic>Polymerase Chain Reaction</topic><topic>Protein Kinases - genetics</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Proteins</topic><topic>Restriction Mapping</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - isolation & purification</topic><topic>Sequence Homology, Amino Acid</topic><topic>Testes</topic><topic>Transferases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clay, Fiona J.</creatorcontrib><creatorcontrib>McEwen, Stephen J.</creatorcontrib><creatorcontrib>Bertoncello, Ivan</creatorcontrib><creatorcontrib>Wilks, Andrew F.</creatorcontrib><creatorcontrib>Dunn, Ashley R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clay, Fiona J.</au><au>McEwen, Stephen J.</au><au>Bertoncello, Ivan</au><au>Wilks, Andrew F.</au><au>Dunn, Ashley R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification and Cloning of a Protein Kinase-Encoding Mouse Gene, Plk, Related to the Polo Gene of Drosophila</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1993-06-01</date><risdate>1993</risdate><volume>90</volume><issue>11</issue><spage>4882</spage><epage>4886</epage><pages>4882-4886</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>We have determined the nucleotide sequence of a cDNA encoding a protein kinase that is closely related to the enzyme encoded by the Drosophila melanogaster mutant polo and that we have designated Plk (polo-like kinase). Plk is also related to the products of the Saccharomyces cerevisiae cell cycle gene MSD2 (CDC5) and the recently described early growth response gene Snk. Together, Plk, polo, Snk, and MSD2 define a subfamily of serine/threonine protein kinases. Plk is expressed at high levels in a number of fetal and newborn mouse tissues but is not expressed in the corresponding adult organs. With the exception of adult hemopoietic tissues, the only adult tissues in which we could detect Plk expression were ovaries and testes. Taken together, the patterns of Plk expression suggest an association with proliferating cells. Since polo is required for mitosis in Drosophila it is possible that Plk is involved in some aspect of cell cycle regulation in mammalian cells.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>8099445</pmid><doi>10.1073/pnas.90.11.4882</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence Amino acids Analytical, structural and metabolic biochemistry Animals Base Sequence Biological and medical sciences Blotting, Northern Bone Marrow - enzymology Brain - enzymology Cellular biology Cloning, Molecular Complementary DNA DNA - genetics DNA - isolation & purification Drosophila Drosophila melanogaster - enzymology Drosophila melanogaster - genetics Enzymes and enzyme inhibitors Fetus Fundamental and applied biological sciences. Psychology Genetics Hematopoietic Stem Cells - enzymology Liver - enzymology Messenger RNA Mice Mice, Inbred C57BL Mice, Inbred ICR Molecular Sequence Data Nucleotide sequences Oligodeoxyribonucleotides Oligonucleotides, Antisense Organ Specificity Ovaries Phylogeny Poly A - genetics Poly A - isolation & purification Polymerase Chain Reaction Protein Kinases - genetics Protein-Serine-Threonine Kinases - genetics Proteins Restriction Mapping RNA, Messenger - genetics RNA, Messenger - isolation & purification Sequence Homology, Amino Acid Testes Transferases |
| title | Identification and Cloning of a Protein Kinase-Encoding Mouse Gene, Plk, Related to the Polo Gene of Drosophila |
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