The azaspirane SKF 105685 ameliorates renal allograft rejection in rats

The azaspirane SKF 105685 (N,N-dimethyl-8, 8-dipropyl-2-azaspiro (4.5) decane-2-propanamine dihydrochloride) has been shown to attenuate or reverse the course of immunologic disease in several animal models, possibly through the induction of nonspecific suppressor activity. To investigate its effect...

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Veröffentlicht in:	Journal of the American Society of Nephrology 1993-04, Vol.3 (10), p.1680-1685
Hauptverfasser:	Fan, P Y, Albrightson, C R, Howell, D N, Best, C, Badger, A M, Coffman, T M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Experimental - drug therapy Drug Evaluation, Preclinical Eicosanoids - biosynthesis Graft Rejection - prevention & control Immunosuppressive Agents - therapeutic use Inflammation Interleukin-1 - biosynthesis Kidney Transplantation - immunology Kidney Transplantation - pathology Male Rats Rats, Inbred ACI - immunology Rats, Inbred Lew - immunology Rats, Inbred Strains - immunology Renal Circulation Spiro Compounds - therapeutic use Transplantation, Homologous
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