Endometrial estrogen and progesterone receptors within 2-14 days of missed menses in the human
Serial changes in the endometrial levels of estrogen and progesterone receptors (ER and PR) were measured in 50 women from days 2 to 14 of missed menses and correlated with the plasma concentrations of hCG, progesterone and 17 beta-estradiol. Both ER and PR of nuclei were higher than cytosolic prote...
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| Veröffentlicht in: | Journal of endocrinological investigation 1993-04, Vol.16 (4), p.247-251 |
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| container_issue | 4 |
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| container_title | Journal of endocrinological investigation |
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| creator | GARG, K SUJATA, P KUMARI, G. L PANDEY, P. K PADUBIDRI, V ANAND, C |
| description | Serial changes in the endometrial levels of estrogen and progesterone receptors (ER and PR) were measured in 50 women from days 2 to 14 of missed menses and correlated with the plasma concentrations of hCG, progesterone and 17 beta-estradiol. Both ER and PR of nuclei were higher than cytosolic proteins, with a shift in the ratio of nER/nPR to nPR from 4th day after missed menses. On Scatchard analysis of the cytosolic and nuclear binding proteins, two classes of proteins, corresponding to Type I and II, were found. While the increasing levels of hCG maintained luteal secretion of progesterone and 17 beta-estradiol at normal mid-luteal phase levels, a gradual increase in 17 beta estradiol from 9th day of missed menses was noted. This delicate balance between circulating levels of progesterone and 17 beta-estradiol and their nuclear receptors at early stages of pregnancy may be of significance. |
| doi_str_mv | 10.1007/BF03348822 |
| format | Article |
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L</creatorcontrib><creatorcontrib>PANDEY, P. K</creatorcontrib><creatorcontrib>PADUBIDRI, V</creatorcontrib><creatorcontrib>ANAND, C</creatorcontrib><title>Endometrial estrogen and progesterone receptors within 2-14 days of missed menses in the human</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><description>Serial changes in the endometrial levels of estrogen and progesterone receptors (ER and PR) were measured in 50 women from days 2 to 14 of missed menses and correlated with the plasma concentrations of hCG, progesterone and 17 beta-estradiol. Both ER and PR of nuclei were higher than cytosolic proteins, with a shift in the ratio of nER/nPR to nPR from 4th day after missed menses. On Scatchard analysis of the cytosolic and nuclear binding proteins, two classes of proteins, corresponding to Type I and II, were found. While the increasing levels of hCG maintained luteal secretion of progesterone and 17 beta-estradiol at normal mid-luteal phase levels, a gradual increase in 17 beta estradiol from 9th day of missed menses was noted. This delicate balance between circulating levels of progesterone and 17 beta-estradiol and their nuclear receptors at early stages of pregnancy may be of significance.</description><subject>Biological and medical sciences</subject><subject>Cell Nucleus - metabolism</subject><subject>Chorionic Gonadotropin - blood</subject><subject>Cytosol - metabolism</subject><subject>Endometrium - metabolism</subject><subject>Endometrium - ultrastructure</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Menstruation</subject><subject>Mother. Fetoplacental unit. Mammary gland. Milk</subject><subject>Pregnancy - metabolism</subject><subject>Pregnancy. 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Lactation</subject><subject>Progesterone - blood</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Time Factors</subject><subject>Vertebrates: reproduction</subject><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFLAzEUhIMotVYv3oUcxIOwmmx2m-SopVWh4EWvLq_Ji13ZzdZkF-m_N9JST-_BfAwzQ8glZ3ecMXn_uGBCFErl-REZc5mzTAk1PSZjJjTPCqblKTmL8YsxIYWSIzJSJS-01GPyMfe2a7EPNTQUYx-6T_QUvKWbvzf2GDqPNKDBTd-FSH_qfl17mme8oBa2kXaOtnWMaGmLPmKkSe3XSNdDC_6cnDhoIl7s74S8L-Zvs-ds-fr0MntYZkZw3mcmZ-CUBFYKDZxJYVVZSGassyDYCkxhwAArrHBc5G6aeiDq1EBydKUGMSE3O9-U-ntIsauUyWDTgMduiJUspVa50gm83YEmdDEGdNUm1C2EbcVZ9Tdm9T9mgq_2rsOqRXtA9-sl_XqvQzTQuADe1PGAFZorIbj4BXTHe7M</recordid><startdate>19930401</startdate><enddate>19930401</enddate><creator>GARG, K</creator><creator>SUJATA, P</creator><creator>KUMARI, G. 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K ; PADUBIDRI, V ; ANAND, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-c20af87a0539a1073d85470cdfda30bac4caca04d3f132f6037ee949771ef59a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Biological and medical sciences</topic><topic>Cell Nucleus - metabolism</topic><topic>Chorionic Gonadotropin - blood</topic><topic>Cytosol - metabolism</topic><topic>Endometrium - metabolism</topic><topic>Endometrium - ultrastructure</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Menstruation</topic><topic>Mother. Fetoplacental unit. Mammary gland. Milk</topic><topic>Pregnancy - metabolism</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Progesterone - blood</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Time Factors</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GARG, K</creatorcontrib><creatorcontrib>SUJATA, P</creatorcontrib><creatorcontrib>KUMARI, G. L</creatorcontrib><creatorcontrib>PANDEY, P. 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On Scatchard analysis of the cytosolic and nuclear binding proteins, two classes of proteins, corresponding to Type I and II, were found. While the increasing levels of hCG maintained luteal secretion of progesterone and 17 beta-estradiol at normal mid-luteal phase levels, a gradual increase in 17 beta estradiol from 9th day of missed menses was noted. This delicate balance between circulating levels of progesterone and 17 beta-estradiol and their nuclear receptors at early stages of pregnancy may be of significance.</abstract><cop>Milano</cop><pub>Kurtis</pub><pmid>8514979</pmid><doi>10.1007/BF03348822</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0391-4097 |
| ispartof | Journal of endocrinological investigation, 1993-04, Vol.16 (4), p.247-251 |
| issn | 0391-4097 1720-8386 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Biological and medical sciences Cell Nucleus - metabolism Chorionic Gonadotropin - blood Cytosol - metabolism Endometrium - metabolism Endometrium - ultrastructure Estradiol - blood Female Fundamental and applied biological sciences. Psychology Humans Menstruation Mother. Fetoplacental unit. Mammary gland. Milk Pregnancy - metabolism Pregnancy. Parturition. Lactation Progesterone - blood Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Time Factors Vertebrates: reproduction |
| title | Endometrial estrogen and progesterone receptors within 2-14 days of missed menses in the human |
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