Embryonic Development and Postnatal Changes in Free d‐Aspartate and d‐Serine in the Human Prefrontal Cortex
: We have analyzed free chiral amino acids (aspartate and serine) in the human frontal cortex at different ontogenic stages (from 14 weeks of gestation to 101 years of age) by HPLC with fluorometric detection after derivatization with N‐tert‐butyl‐oxycarbonyl‐l‐cysteine and o‐phthaldialdehyde. Excep...
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| Veröffentlicht in: | Journal of neurochemistry 1993-07, Vol.61 (1), p.348-351 |
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| creator | Hashimoto, Atsushi Kumashiro, Shin Nishikawa, Toru Oka, Takae Takahashi, Kiyohisa Mito, Takashi Takashima, Sachio Doi, Nagafumi Mizutani, Yoshihiko Yamazaki, Tatsuji Kaneko, Tsuguo Ootomo, Eiji |
| description | : We have analyzed free chiral amino acids (aspartate and serine) in the human frontal cortex at different ontogenic stages (from 14 weeks of gestation to 101 years of age) by HPLC with fluorometric detection after derivatization with N‐tert‐butyl‐oxycarbonyl‐l‐cysteine and o‐phthaldialdehyde. Exceptionally high levels of free d‐aspartate and d‐serine were demonstrated in the fetal cortex at gestational week 14. The ratios of d‐aspartate and of d‐serine to the total corresponding amino acids were also high, at 0.63 and 0.27, respectively. The concentration of d‐aspartate dramatically decreased to a trace level by gestational week 41 and then remained very low during all postnatal stages. In contrast, the frontal tip contained persistently high levels of d‐serine throughout embryonic and postnatal life, whereas the d‐amino acid content in adolescents and aged individuals was about half of that in the fetuses. Because d‐aspartate and d‐serine are known to have selective actions at the NMDA‐type excitatory amino acid receptor, the present data suggest that these d‐amino acids might play a pivotal role in cerebral development and functions that are related to the NMDA receptor. |
| doi_str_mv | 10.1111/j.1471-4159.1993.tb03575.x |
| format | Article |
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Exceptionally high levels of free d‐aspartate and d‐serine were demonstrated in the fetal cortex at gestational week 14. The ratios of d‐aspartate and of d‐serine to the total corresponding amino acids were also high, at 0.63 and 0.27, respectively. The concentration of d‐aspartate dramatically decreased to a trace level by gestational week 41 and then remained very low during all postnatal stages. In contrast, the frontal tip contained persistently high levels of d‐serine throughout embryonic and postnatal life, whereas the d‐amino acid content in adolescents and aged individuals was about half of that in the fetuses. Because d‐aspartate and d‐serine are known to have selective actions at the NMDA‐type excitatory amino acid receptor, the present data suggest that these d‐amino acids might play a pivotal role in cerebral development and functions that are related to the NMDA receptor.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.1993.tb03575.x</identifier><identifier>PMID: 8515283</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging ; Aging - metabolism ; Aspartic Acid - metabolism ; Biochemistry and metabolism ; Biological and medical sciences ; Central nervous system ; Child ; Child, Preschool ; Chromatography, High Pressure Liquid ; Development ; d‐Aspartate ; d‐Serine ; Embryo, Mammalian - metabolism ; Embryonic and Fetal Development ; Frontal Lobe - embryology ; Frontal Lobe - metabolism ; Fundamental and applied biological sciences. Psychology ; Human frontal cortex ; Humans ; Infant ; Infant, Newborn ; Middle Aged ; NMDA receptor ; Osmolar Concentration ; Serine - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Journal of neurochemistry, 1993-07, Vol.61 (1), p.348-351</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4958-ec418f0acb1e00a02d6cd8b42f1611917a89ecfdc4706a071b1d13f00b273a9b3</citedby><cites>FETCH-LOGICAL-c4958-ec418f0acb1e00a02d6cd8b42f1611917a89ecfdc4706a071b1d13f00b273a9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.1993.tb03575.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.1993.tb03575.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4773816$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8515283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hashimoto, Atsushi</creatorcontrib><creatorcontrib>Kumashiro, Shin</creatorcontrib><creatorcontrib>Nishikawa, Toru</creatorcontrib><creatorcontrib>Oka, Takae</creatorcontrib><creatorcontrib>Takahashi, Kiyohisa</creatorcontrib><creatorcontrib>Mito, Takashi</creatorcontrib><creatorcontrib>Takashima, Sachio</creatorcontrib><creatorcontrib>Doi, Nagafumi</creatorcontrib><creatorcontrib>Mizutani, Yoshihiko</creatorcontrib><creatorcontrib>Yamazaki, Tatsuji</creatorcontrib><creatorcontrib>Kaneko, Tsuguo</creatorcontrib><creatorcontrib>Ootomo, Eiji</creatorcontrib><title>Embryonic Development and Postnatal Changes in Free d‐Aspartate and d‐Serine in the Human Prefrontal Cortex</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>: We have analyzed free chiral amino acids (aspartate and serine) in the human frontal cortex at different ontogenic stages (from 14 weeks of gestation to 101 years of age) by HPLC with fluorometric detection after derivatization with N‐tert‐butyl‐oxycarbonyl‐l‐cysteine and o‐phthaldialdehyde. Exceptionally high levels of free d‐aspartate and d‐serine were demonstrated in the fetal cortex at gestational week 14. The ratios of d‐aspartate and of d‐serine to the total corresponding amino acids were also high, at 0.63 and 0.27, respectively. The concentration of d‐aspartate dramatically decreased to a trace level by gestational week 41 and then remained very low during all postnatal stages. In contrast, the frontal tip contained persistently high levels of d‐serine throughout embryonic and postnatal life, whereas the d‐amino acid content in adolescents and aged individuals was about half of that in the fetuses. Because d‐aspartate and d‐serine are known to have selective actions at the NMDA‐type excitatory amino acid receptor, the present data suggest that these d‐amino acids might play a pivotal role in cerebral development and functions that are related to the NMDA receptor.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - metabolism</subject><subject>Aspartic Acid - metabolism</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Development</subject><subject>d‐Aspartate</subject><subject>d‐Serine</subject><subject>Embryo, Mammalian - metabolism</subject><subject>Embryonic and Fetal Development</subject><subject>Frontal Lobe - embryology</subject><subject>Frontal Lobe - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human frontal cortex</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Middle Aged</subject><subject>NMDA receptor</subject><subject>Osmolar Concentration</subject><subject>Serine - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkc1u1DAUhS1EVaaFR0CKEGKX1Dd2bIcFUjW0tFUFlYC15Tg3NKPEmdoemNn1EXhGnoSkE80W4Y0ln-_--BxC3gDNYDxnqwy4hJRDUWZQliyLFWWFLLLtM7I4SM_JgtI8Txnl-QtyEsKKUhBcwDE5VgUUuWILMlz0ld8NrrXJR_yJ3bDu0cXEuDq5G0J0JpouWd4b9wND0rrk0iMm9Z_H3-dhbXw0EZ_Y6eUr-tbhBMV7TK42vXHJncfGD-6pyeAjbl-So8Z0AV_N9yn5fnnxbXmV3n75dL08v00tLwuVouWgGmpsBUipoXktbK0qnjcgAEqQRpVom9pySYWhEiqogTWUVrlkpqzYKXm377v2w8MGQ9R9Gyx2nXE4bIKWhSylKtQ_QRCiEFKUI_h-D1o_hDD-S6992xu_00D1FIte6cl7PXmvp1j0HIvejsWv5ymbqsf6UDrnMOpvZ90Ea7rGG2fbcMC4lEyBGLEPe-xX2-HuPxbQN5-XjCv2F2C-rBQ</recordid><startdate>199307</startdate><enddate>199307</enddate><creator>Hashimoto, Atsushi</creator><creator>Kumashiro, Shin</creator><creator>Nishikawa, Toru</creator><creator>Oka, Takae</creator><creator>Takahashi, Kiyohisa</creator><creator>Mito, Takashi</creator><creator>Takashima, Sachio</creator><creator>Doi, Nagafumi</creator><creator>Mizutani, Yoshihiko</creator><creator>Yamazaki, Tatsuji</creator><creator>Kaneko, Tsuguo</creator><creator>Ootomo, Eiji</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>199307</creationdate><title>Embryonic Development and Postnatal Changes in Free d‐Aspartate and d‐Serine in the Human Prefrontal Cortex</title><author>Hashimoto, Atsushi ; Kumashiro, Shin ; Nishikawa, Toru ; Oka, Takae ; Takahashi, Kiyohisa ; Mito, Takashi ; Takashima, Sachio ; Doi, Nagafumi ; Mizutani, Yoshihiko ; Yamazaki, Tatsuji ; Kaneko, Tsuguo ; Ootomo, Eiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4958-ec418f0acb1e00a02d6cd8b42f1611917a89ecfdc4706a071b1d13f00b273a9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging - metabolism</topic><topic>Aspartic Acid - metabolism</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Development</topic><topic>d‐Aspartate</topic><topic>d‐Serine</topic><topic>Embryo, Mammalian - metabolism</topic><topic>Embryonic and Fetal Development</topic><topic>Frontal Lobe - embryology</topic><topic>Frontal Lobe - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human frontal cortex</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Middle Aged</topic><topic>NMDA receptor</topic><topic>Osmolar Concentration</topic><topic>Serine - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashimoto, Atsushi</creatorcontrib><creatorcontrib>Kumashiro, Shin</creatorcontrib><creatorcontrib>Nishikawa, Toru</creatorcontrib><creatorcontrib>Oka, Takae</creatorcontrib><creatorcontrib>Takahashi, Kiyohisa</creatorcontrib><creatorcontrib>Mito, Takashi</creatorcontrib><creatorcontrib>Takashima, Sachio</creatorcontrib><creatorcontrib>Doi, Nagafumi</creatorcontrib><creatorcontrib>Mizutani, Yoshihiko</creatorcontrib><creatorcontrib>Yamazaki, Tatsuji</creatorcontrib><creatorcontrib>Kaneko, Tsuguo</creatorcontrib><creatorcontrib>Ootomo, Eiji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashimoto, Atsushi</au><au>Kumashiro, Shin</au><au>Nishikawa, Toru</au><au>Oka, Takae</au><au>Takahashi, Kiyohisa</au><au>Mito, Takashi</au><au>Takashima, Sachio</au><au>Doi, Nagafumi</au><au>Mizutani, Yoshihiko</au><au>Yamazaki, Tatsuji</au><au>Kaneko, Tsuguo</au><au>Ootomo, Eiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Embryonic Development and Postnatal Changes in Free d‐Aspartate and d‐Serine in the Human Prefrontal Cortex</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>1993-07</date><risdate>1993</risdate><volume>61</volume><issue>1</issue><spage>348</spage><epage>351</epage><pages>348-351</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>: We have analyzed free chiral amino acids (aspartate and serine) in the human frontal cortex at different ontogenic stages (from 14 weeks of gestation to 101 years of age) by HPLC with fluorometric detection after derivatization with N‐tert‐butyl‐oxycarbonyl‐l‐cysteine and o‐phthaldialdehyde. Exceptionally high levels of free d‐aspartate and d‐serine were demonstrated in the fetal cortex at gestational week 14. The ratios of d‐aspartate and of d‐serine to the total corresponding amino acids were also high, at 0.63 and 0.27, respectively. The concentration of d‐aspartate dramatically decreased to a trace level by gestational week 41 and then remained very low during all postnatal stages. In contrast, the frontal tip contained persistently high levels of d‐serine throughout embryonic and postnatal life, whereas the d‐amino acid content in adolescents and aged individuals was about half of that in the fetuses. Because d‐aspartate and d‐serine are known to have selective actions at the NMDA‐type excitatory amino acid receptor, the present data suggest that these d‐amino acids might play a pivotal role in cerebral development and functions that are related to the NMDA receptor.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8515283</pmid><doi>10.1111/j.1471-4159.1993.tb03575.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of neurochemistry, 1993-07, Vol.61 (1), p.348-351 |
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| subjects | Adolescent Adult Aged Aged, 80 and over Aging Aging - metabolism Aspartic Acid - metabolism Biochemistry and metabolism Biological and medical sciences Central nervous system Child Child, Preschool Chromatography, High Pressure Liquid Development d‐Aspartate d‐Serine Embryo, Mammalian - metabolism Embryonic and Fetal Development Frontal Lobe - embryology Frontal Lobe - metabolism Fundamental and applied biological sciences. Psychology Human frontal cortex Humans Infant Infant, Newborn Middle Aged NMDA receptor Osmolar Concentration Serine - metabolism Vertebrates: nervous system and sense organs |
| title | Embryonic Development and Postnatal Changes in Free d‐Aspartate and d‐Serine in the Human Prefrontal Cortex |
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