bcl‐2 Rearrangements in de novo diffuse large cell lymphoma. Association with distinctive clinical features

Background. The frequency and clinical significance of bcl‐2 rearrangement in de novo B‐cell diffuse large cell lymphoma is largely unknown. Methods. Using Southern blot hybridization and multiple DNA probes, the status of the protooncogene bcl‐2 was investigated in frozen tissue samples from 45 car...

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Veröffentlicht in:	Cancer 1993-07, Vol.72 (1), p.231-236
Hauptverfasser:	Jacobson, Joseph O., Wilkes, Barbara M., Kwiatkowski, David J., Medeiros, L. Jeffrey, Aisenberg, Alan C., Harris, Nancy L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over bcl‐2 Biological and medical sciences Female Gene Rearrangement, B-Lymphocyte - genetics Hematologic and hematopoietic diseases Humans large cell lymphoma Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, B-Cell - genetics Lymphoma, B-Cell - mortality Lymphoma, B-Cell - pathology Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - mortality Lymphoma, Large B-Cell, Diffuse - pathology Male Medical sciences Middle Aged Proto-Oncogenes - genetics Survival Analysis t(14 18)
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