The effect of hypoxia on acquired drug resistance and response to epidermal growth factor in chinese hamster lung fibroblasts and human breast‐cancer cells in vitro

Prolonged hypoxia induced transient drug resistance in Chinese hamster lung fibroblasts. Previously hypoxic cells were resistant to adriamycin and resistant to etoposide. Complete recovery of etoposide sensitivity was observed following re‐aeration for 24 hr. A change in P‐glycoprotein expression wa...

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Veröffentlicht in:	International journal of cancer 1993-06, Vol.54 (4), p.650-655
Hauptverfasser:	Kalra, R., Jones, A‐M., Kirk, J., Adams, G. E., Stratford, I. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell Hypoxia - physiology Cricetinae Cricetulus Doxorubicin - pharmacology Drug Resistance - physiology Epidermal Growth Factor - pharmacology Etoposide - pharmacology Fibroblasts - drug effects General aspects Humans Lung - drug effects Lung - pathology Medical sciences Pharmacology. Drug treatments Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - physiology
Online-Zugang:	Volltext
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