Clinical Relevance of Serum Amyloid a Protein Monitoring in Urinary Tract Infections
We have evaluated the clinical relevance of monitoring acute phase proteins in severe urinary tract infection. Body temperature, white blood cell count, erythrocyte sedimentation rate, serum amyloid A protein (SAA), C-reactive protein (CRP), α-1-antichymotrypsin (ACT) and α-1-acid glycoprotein (AGP)...
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| Veröffentlicht in: | Annals of clinical biochemistry 1993-05, Vol.30 (3), p.272-277 |
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| container_end_page | 277 |
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| container_title | Annals of clinical biochemistry |
| container_volume | 30 |
| creator | Časl, Martin-Tino Sabljar-Matovinović, Mirjana Kovačević, Sandra Počanić, Darko Preden-Kereković, Vladimira Jagarinec, Nada |
| description | We have evaluated the clinical relevance of monitoring acute phase proteins in severe urinary tract infection. Body temperature, white blood cell count, erythrocyte sedimentation rate, serum amyloid A protein (SAA), C-reactive protein (CRP), α-1-antichymotrypsin (ACT) and α-1-acid glycoprotein (AGP) were determined daily in sera from 18 treated patients.
Two patterns of response could be identified: responders and non-responders whose therapy had to be changed. Mean values for each acute phase protein were calculated daily in both responders and non-responders. Statistical evaluation of the significance between the means for each protein was also performed on a daily basis and showed P < 0·01 for SAA and CRP on day 3, for ACT on day 5, and for AGP on day 6.
SAA and CRP appear to be the most reliable markers for antimicrobial therapy monitoring in patients with urinary tract infections. |
| doi_str_mv | 10.1177/000456329303000308 |
| format | Article |
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Two patterns of response could be identified: responders and non-responders whose therapy had to be changed. Mean values for each acute phase protein were calculated daily in both responders and non-responders. Statistical evaluation of the significance between the means for each protein was also performed on a daily basis and showed P < 0·01 for SAA and CRP on day 3, for ACT on day 5, and for AGP on day 6.
SAA and CRP appear to be the most reliable markers for antimicrobial therapy monitoring in patients with urinary tract infections.</description><identifier>ISSN: 0004-5632</identifier><identifier>EISSN: 1758-1001</identifier><identifier>DOI: 10.1177/000456329303000308</identifier><identifier>PMID: 8517610</identifier><identifier>CODEN: ACBOBU</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Aged ; Aged, 80 and over ; alpha 1-Antichymotrypsin - analysis ; Anti-Bacterial Agents - therapeutic use ; Biological and medical sciences ; Blood Sedimentation ; C-Reactive Protein - analysis ; Female ; Humans ; Leukocyte Count ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Orosomucoid - analysis ; Serum Amyloid A Protein - analysis ; Urinary system involvement in other diseases. Miscellaneous ; Urinary Tract Infections - blood ; Urinary Tract Infections - drug therapy ; Urinary tract. Prostate gland</subject><ispartof>Annals of clinical biochemistry, 1993-05, Vol.30 (3), p.272-277</ispartof><rights>1993 Association for Clinical Biochemistry</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-eb7df131ae45ef0f075b7b65c67e444dce6960738b456096f9304d2930f63bd3</citedby><cites>FETCH-LOGICAL-c367t-eb7df131ae45ef0f075b7b65c67e444dce6960738b456096f9304d2930f63bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4795030$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8517610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Časl, Martin-Tino</creatorcontrib><creatorcontrib>Sabljar-Matovinović, Mirjana</creatorcontrib><creatorcontrib>Kovačević, Sandra</creatorcontrib><creatorcontrib>Počanić, Darko</creatorcontrib><creatorcontrib>Preden-Kereković, Vladimira</creatorcontrib><creatorcontrib>Jagarinec, Nada</creatorcontrib><title>Clinical Relevance of Serum Amyloid a Protein Monitoring in Urinary Tract Infections</title><title>Annals of clinical biochemistry</title><addtitle>Ann Clin Biochem</addtitle><description>We have evaluated the clinical relevance of monitoring acute phase proteins in severe urinary tract infection. Body temperature, white blood cell count, erythrocyte sedimentation rate, serum amyloid A protein (SAA), C-reactive protein (CRP), α-1-antichymotrypsin (ACT) and α-1-acid glycoprotein (AGP) were determined daily in sera from 18 treated patients.
Two patterns of response could be identified: responders and non-responders whose therapy had to be changed. Mean values for each acute phase protein were calculated daily in both responders and non-responders. Statistical evaluation of the significance between the means for each protein was also performed on a daily basis and showed P < 0·01 for SAA and CRP on day 3, for ACT on day 5, and for AGP on day 6.
SAA and CRP appear to be the most reliable markers for antimicrobial therapy monitoring in patients with urinary tract infections.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>alpha 1-Antichymotrypsin - analysis</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood Sedimentation</subject><subject>C-Reactive Protein - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Orosomucoid - analysis</subject><subject>Serum Amyloid A Protein - analysis</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary Tract Infections - blood</subject><subject>Urinary Tract Infections - drug therapy</subject><subject>Urinary tract. Prostate gland</subject><issn>0004-5632</issn><issn>1758-1001</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFtLAzEQhYMotV7-gCDkQXxbTZpb91GKl4KiaH1estlJSdlNarIr9N-b0uKL4FNmmG_O5ByELii5oVSpW0IIF5JNSkZYrhmZHqAxVWJaUELoIRpvgWJLHKOTlFa5nShCRmg0FVRJSsZoMWudd0a3-B1a-NbeAA4Wf0AcOnzXbdrgGqzxWww9OI9fgnd9iM4vce4-c6HjBi-iNj2eewumd8GnM3RkdZvgfP-eosXD_WL2VDy_Ps5nd8-FYVL1BdSqsZRRDVyAJZYoUataCiMVcM4bA7KURLFpnV2SUtrskzdbt1ayumGn6Honu47ha4DUV51LBtpWewhDqpRQJWdcZHCyA00MKUWw1Tq6Lv-8oqTaJln9TTIvXe7Vh7qD5ndlH12eX-3nOuX8bMzZufSLcVWKrJOx2x2W9BKqVRiiz5H8d_gHm92HBQ</recordid><startdate>19930501</startdate><enddate>19930501</enddate><creator>Časl, Martin-Tino</creator><creator>Sabljar-Matovinović, Mirjana</creator><creator>Kovačević, Sandra</creator><creator>Počanić, Darko</creator><creator>Preden-Kereković, Vladimira</creator><creator>Jagarinec, Nada</creator><general>SAGE Publications</general><general>Royal Society of Medicine Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930501</creationdate><title>Clinical Relevance of Serum Amyloid a Protein Monitoring in Urinary Tract Infections</title><author>Časl, Martin-Tino ; Sabljar-Matovinović, Mirjana ; Kovačević, Sandra ; Počanić, Darko ; Preden-Kereković, Vladimira ; Jagarinec, Nada</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-eb7df131ae45ef0f075b7b65c67e444dce6960738b456096f9304d2930f63bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>alpha 1-Antichymotrypsin - analysis</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood Sedimentation</topic><topic>C-Reactive Protein - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Orosomucoid - analysis</topic><topic>Serum Amyloid A Protein - analysis</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary Tract Infections - blood</topic><topic>Urinary Tract Infections - drug therapy</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Časl, Martin-Tino</creatorcontrib><creatorcontrib>Sabljar-Matovinović, Mirjana</creatorcontrib><creatorcontrib>Kovačević, Sandra</creatorcontrib><creatorcontrib>Počanić, Darko</creatorcontrib><creatorcontrib>Preden-Kereković, Vladimira</creatorcontrib><creatorcontrib>Jagarinec, Nada</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Časl, Martin-Tino</au><au>Sabljar-Matovinović, Mirjana</au><au>Kovačević, Sandra</au><au>Počanić, Darko</au><au>Preden-Kereković, Vladimira</au><au>Jagarinec, Nada</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Relevance of Serum Amyloid a Protein Monitoring in Urinary Tract Infections</atitle><jtitle>Annals of clinical biochemistry</jtitle><addtitle>Ann Clin Biochem</addtitle><date>1993-05-01</date><risdate>1993</risdate><volume>30</volume><issue>3</issue><spage>272</spage><epage>277</epage><pages>272-277</pages><issn>0004-5632</issn><eissn>1758-1001</eissn><coden>ACBOBU</coden><abstract>We have evaluated the clinical relevance of monitoring acute phase proteins in severe urinary tract infection. Body temperature, white blood cell count, erythrocyte sedimentation rate, serum amyloid A protein (SAA), C-reactive protein (CRP), α-1-antichymotrypsin (ACT) and α-1-acid glycoprotein (AGP) were determined daily in sera from 18 treated patients.
Two patterns of response could be identified: responders and non-responders whose therapy had to be changed. Mean values for each acute phase protein were calculated daily in both responders and non-responders. Statistical evaluation of the significance between the means for each protein was also performed on a daily basis and showed P < 0·01 for SAA and CRP on day 3, for ACT on day 5, and for AGP on day 6.
SAA and CRP appear to be the most reliable markers for antimicrobial therapy monitoring in patients with urinary tract infections.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>8517610</pmid><doi>10.1177/000456329303000308</doi><tpages>6</tpages></addata></record> |
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| ispartof | Annals of clinical biochemistry, 1993-05, Vol.30 (3), p.272-277 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over alpha 1-Antichymotrypsin - analysis Anti-Bacterial Agents - therapeutic use Biological and medical sciences Blood Sedimentation C-Reactive Protein - analysis Female Humans Leukocyte Count Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Orosomucoid - analysis Serum Amyloid A Protein - analysis Urinary system involvement in other diseases. Miscellaneous Urinary Tract Infections - blood Urinary Tract Infections - drug therapy Urinary tract. Prostate gland |
| title | Clinical Relevance of Serum Amyloid a Protein Monitoring in Urinary Tract Infections |
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