Internalization and recycling of activated thrombin receptors

Shortly after activation by either thrombin or the tethered ligand domain peptide SFLLRN, thrombin receptors undergo homologous desensitization, temporarily losing their ability to respond to both agonists. We have examined the role of receptor internalization and recycling in this process using rec...

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Veröffentlicht in:	The Journal of biological chemistry 1993-06, Vol.268 (18), p.13756-13763
Hauptverfasser:	HOXIE, J. A, AHUJA, M, BELMONTE, E, PIZARRO, S, PARTON, R, BRASS, L. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biological and medical sciences Cell Membrane - metabolism Cell receptors Cell structures and functions Cells, Cultured Coated Pits, Cell-Membrane - metabolism Fundamental and applied biological sciences. Psychology Humans Microscopy, Fluorescence Miscellaneous Molecular and cellular biology Molecular Sequence Data Peptides - pharmacology Receptors, Cell Surface - drug effects Receptors, Cell Surface - metabolism Receptors, Thrombin Tumor Cells, Cultured
Online-Zugang:	Volltext
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