Expression, Purification and Characterization of Multigram Amounts of a Recombinant Hybrid HV1-HV2 Hirudin Variant Expressed in Saccharomyces cerevisiae

Hirudin (HIR), derived from leeches, and tick anticoagulant peptide (TAP) are polypeptide protease inhibitors of thrombin and coagulation factor Xa (fXa), respectively, and they have both shown utility in vitro and in vivo as potent antithrombotic agents. A thorough side-by-side comparison of the in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Protein expression and purification 1993-06, Vol.4 (3), p.247-255
Hauptverfasser:	Lehman, E.D., Joyce, J.G., Bailey, F.J., Markus, H.Z., Schultz, L.D., Dunwiddie, C.T., Jacobson, M.A., Miller, W.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Carboxypeptidases - metabolism Cathepsin A Cloning, Molecular Gene Expression Genes, Synthetic - genetics Genetic Variation Hirudins - biosynthesis Hirudins - genetics Hirudins - isolation & purification Hirudins - metabolism Hirudins - pharmacology Molecular Sequence Data Peptide Fragments Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - isolation & purification Recombinant Fusion Proteins - pharmacology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins Sequence Analysis Thrombin - antagonists & inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!