The Determination of Dual Pancreatic and Renal Transplant Graft Vascular Patency with Tc-99m HMPAO
Combined pancreatic-renal transplants promise the restoration of physiologic control of serum glucose and normal renal function. As pancreatic transplantation becomes more common, there is an increased need for rapid, noninvasive evaluation of vascular graft patency and function. Pancreatic transpla...
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| Veröffentlicht in: | Clinical nuclear medicine 1993-05, Vol.18 (5), p.394-399 |
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| creator | FORD, PATRICK V SPIETH, MICHAEL E VOGEL, JOHN M |
| description | Combined pancreatic-renal transplants promise the restoration of physiologic control of serum glucose and normal renal function. As pancreatic transplantation becomes more common, there is an increased need for rapid, noninvasive evaluation of vascular graft patency and function. Pancreatic transplants share the renal transplantʼs complications of ischemia at harvest but are at greater risk. Tc-99m HMPAO is a lipophilic complex that clears rapidly from the blood after intravenous injection, and tissue accumulation is proportional to regional perfusion. Using Tc-99m HMPAO to monitor the vascular competency has the advantage of a high count rate during dynamic scintigrams but, in contrast to Tc-99m DTPA, has excellent delayed static images. Four patients who received combined cadaveric pancreaticrenal transplants and had a total of eight Tc-99m HMPAO scintigraphic examinations were reviewed. |
| doi_str_mv | 10.1097/00003072-199305000-00005 |
| format | Article |
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As pancreatic transplantation becomes more common, there is an increased need for rapid, noninvasive evaluation of vascular graft patency and function. Pancreatic transplants share the renal transplantʼs complications of ischemia at harvest but are at greater risk. Tc-99m HMPAO is a lipophilic complex that clears rapidly from the blood after intravenous injection, and tissue accumulation is proportional to regional perfusion. Using Tc-99m HMPAO to monitor the vascular competency has the advantage of a high count rate during dynamic scintigrams but, in contrast to Tc-99m DTPA, has excellent delayed static images. Four patients who received combined cadaveric pancreaticrenal transplants and had a total of eight Tc-99m HMPAO scintigraphic examinations were reviewed.</description><identifier>ISSN: 0363-9762</identifier><identifier>EISSN: 1536-0229</identifier><identifier>DOI: 10.1097/00003072-199305000-00005</identifier><identifier>PMID: 8508573</identifier><identifier>CODEN: CNMEDK</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott-Raven Publishers</publisher><subject>Adult ; Biological and medical sciences ; Cadaver ; Diabetes Mellitus, Type 1 - surgery ; Female ; Graft Survival - physiology ; Humans ; Kidney Transplantation - diagnostic imaging ; Male ; Medical sciences ; Organotechnetium Compounds ; Oximes ; Pancreas Transplantation - diagnostic imaging ; Radionuclide Imaging ; Renal Insufficiency - surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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As pancreatic transplantation becomes more common, there is an increased need for rapid, noninvasive evaluation of vascular graft patency and function. Pancreatic transplants share the renal transplantʼs complications of ischemia at harvest but are at greater risk. Tc-99m HMPAO is a lipophilic complex that clears rapidly from the blood after intravenous injection, and tissue accumulation is proportional to regional perfusion. Using Tc-99m HMPAO to monitor the vascular competency has the advantage of a high count rate during dynamic scintigrams but, in contrast to Tc-99m DTPA, has excellent delayed static images. Four patients who received combined cadaveric pancreaticrenal transplants and had a total of eight Tc-99m HMPAO scintigraphic examinations were reviewed.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cadaver</subject><subject>Diabetes Mellitus, Type 1 - surgery</subject><subject>Female</subject><subject>Graft Survival - physiology</subject><subject>Humans</subject><subject>Kidney Transplantation - diagnostic imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Organotechnetium Compounds</subject><subject>Oximes</subject><subject>Pancreas Transplantation - diagnostic imaging</subject><subject>Radionuclide Imaging</subject><subject>Renal Insufficiency - surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>Technetium Tc 99m Exametazime</subject><subject>Vascular Patency - physiology</subject><issn>0363-9762</issn><issn>1536-0229</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v3CAQhlHVKN2k_QmVOES9OQEDxhyj3XxUSpSocntFYzzWusX2Bmyt8u_DZrd7CxfEO8_A6IEQytklZ0ZfsbQE03nGjRFMpVO2i9QnsuBKFBnLc_OZLJgoRGZ0kX8hZzH-ZYwXvJCn5LRUrFRaLEhdrZGucMLQdwNM3TjQsaWrGTx9hsEFTJmjMDT0Fw4prAIMceNhmOhdgHaifyC62UNI-ISDe6XbblrTymXG9PT-8fn66Ss5acFH_HbYz8nv25tqeZ89PN39XF4_ZE6UUmWqrrnMZZtLkcbmxqEwCkregEaZG1WCaXStGIDLRamdTrDTbcsBsUGmxTn5sb93E8aXGeNk-y469GlYHOdotdKGKykTWO5BF8YYA7Z2E7oewqvlzO702v967VHve6RS6_fDG3PdY3NsPPhM9YtDPWkB3yZbrotHTOpClHyHyT22HX1SH__5eYvBrhH8tLYffa54A76MkBw</recordid><startdate>199305</startdate><enddate>199305</enddate><creator>FORD, PATRICK V</creator><creator>SPIETH, MICHAEL E</creator><creator>VOGEL, JOHN M</creator><general>Lippincott-Raven Publishers</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199305</creationdate><title>The Determination of Dual Pancreatic and Renal Transplant Graft Vascular Patency with Tc-99m HMPAO</title><author>FORD, PATRICK V ; SPIETH, MICHAEL E ; VOGEL, JOHN M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3845-5bb1424f24303619ce395a81da7e42958a9d7b50aac2387c7424c7ff1aeede073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cadaver</topic><topic>Diabetes Mellitus, Type 1 - surgery</topic><topic>Female</topic><topic>Graft Survival - physiology</topic><topic>Humans</topic><topic>Kidney Transplantation - diagnostic imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Organotechnetium Compounds</topic><topic>Oximes</topic><topic>Pancreas Transplantation - diagnostic imaging</topic><topic>Radionuclide Imaging</topic><topic>Renal Insufficiency - surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>Technetium Tc 99m Exametazime</topic><topic>Vascular Patency - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FORD, PATRICK V</creatorcontrib><creatorcontrib>SPIETH, MICHAEL E</creatorcontrib><creatorcontrib>VOGEL, JOHN M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FORD, PATRICK V</au><au>SPIETH, MICHAEL E</au><au>VOGEL, JOHN M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Determination of Dual Pancreatic and Renal Transplant Graft Vascular Patency with Tc-99m HMPAO</atitle><jtitle>Clinical nuclear medicine</jtitle><addtitle>Clin Nucl Med</addtitle><date>1993-05</date><risdate>1993</risdate><volume>18</volume><issue>5</issue><spage>394</spage><epage>399</epage><pages>394-399</pages><issn>0363-9762</issn><eissn>1536-0229</eissn><coden>CNMEDK</coden><abstract>Combined pancreatic-renal transplants promise the restoration of physiologic control of serum glucose and normal renal function. As pancreatic transplantation becomes more common, there is an increased need for rapid, noninvasive evaluation of vascular graft patency and function. Pancreatic transplants share the renal transplantʼs complications of ischemia at harvest but are at greater risk. Tc-99m HMPAO is a lipophilic complex that clears rapidly from the blood after intravenous injection, and tissue accumulation is proportional to regional perfusion. Using Tc-99m HMPAO to monitor the vascular competency has the advantage of a high count rate during dynamic scintigrams but, in contrast to Tc-99m DTPA, has excellent delayed static images. Four patients who received combined cadaveric pancreaticrenal transplants and had a total of eight Tc-99m HMPAO scintigraphic examinations were reviewed.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>8508573</pmid><doi>10.1097/00003072-199305000-00005</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0363-9762 |
| ispartof | Clinical nuclear medicine, 1993-05, Vol.18 (5), p.394-399 |
| issn | 0363-9762 1536-0229 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Biological and medical sciences Cadaver Diabetes Mellitus, Type 1 - surgery Female Graft Survival - physiology Humans Kidney Transplantation - diagnostic imaging Male Medical sciences Organotechnetium Compounds Oximes Pancreas Transplantation - diagnostic imaging Radionuclide Imaging Renal Insufficiency - surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Technetium Tc 99m Exametazime Vascular Patency - physiology |
| title | The Determination of Dual Pancreatic and Renal Transplant Graft Vascular Patency with Tc-99m HMPAO |
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