Increased platelet activating factor in the tracheal aspirates from neonates with patent ductus arteriosus
We investigated platelet-activating factor (PAF) in the tracheal aspirate from 3 intubated low birth weight infants with symptomatic patent ductus arteriosus (PDA). PAF increased with the onset of symptomatic PDA and decreased to the control range soon after the ductal closure. The concentration of...
Gespeichert in:
| Veröffentlicht in: | Clinica chimica acta 1993-04, Vol.215 (1), p.73-79 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 79 |
|---|---|
| container_issue | 1 |
| container_start_page | 73 |
| container_title | Clinica chimica acta |
| container_volume | 215 |
| creator | Koyama, Norihisa Ogawa, Yunosuke Kamiya, Kenji Eguchi, Hideshi Tanaka, Taihei Takasaki, Jiro Ohama, Yoichi Itakura, Yukino Kaneko, Kohji |
| description | We investigated platelet-activating factor (PAF) in the tracheal aspirate from 3 intubated low birth weight infants with symptomatic patent ductus arteriosus (PDA). PAF increased with the onset of symptomatic PDA and decreased to the control range soon after the ductal closure. The concentration of PAF in 26 samples taken during symptomatic PDA (median 16 pg/μg lipid phosphorus, range 1.4–1,200 pg/μg lipid phosphorus) was significantly higher than that of 31 samples from the same three patients during the periods without symptomatic PDA (median 1.9 pg/μg lipid phosphorus, range 0–12 pg/μg lipid phosphorus;
P < 0.001). All 3 infants later developed chronic lung disease. These results suggest that large shunting PDA provokes PAF release to the air way of the neonate and that PAF might play a role in chronic lung disease developing after symptomatic PDA. |
| doi_str_mv | 10.1016/0009-8981(93)90250-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75788214</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0009898193902508</els_id><sourcerecordid>75788214</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-13c00154b564c99c452479123e69846a1650fb7b2c48b6099860883b1ed091c83</originalsourceid><addsrcrecordid>eNp9kMFu1DAQhi0EKtvCG4DkA6rgELBjx7EvSKiitFIlLnC2nMmEdZVNgsdpxdvX213tkZNnNJ9_zXyMvZPisxTSfBFCuMo6Kz869cmJuhGVfcE20raqUtrVL9nmhLxm50T3pdXCyDN2ZhupmlZs2P3tBAkDYc-XMWQcMfMAOT6EHKc_fCj1nHiceN4izynAFsPIAy0xFZr4kOYdn3CenrvHmLd8KeWUeb9CXomHlDHFmVZ6w14NYSR8e3wv2O_r77-ubqq7nz9ur77dVaCsyZVUIIRsdNcYDc6BbmrdOlkrNM5qE6RpxNC1XQ3adkY4Z42wVnUSe-EkWHXBLg-5S5r_rkjZ7yIBjmMoe67k26a1tpa6gPoAQpqJEg5-SXEX0j8vhd8r9nt_fu_PO-WfFft9_vtj_trtsD99Ojot8w_HeSAI45DCBJFOmG61LtcU7OsBw-LiIWLyBBEnwD4mhOz7Of5_jyemSZfC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75788214</pqid></control><display><type>article</type><title>Increased platelet activating factor in the tracheal aspirates from neonates with patent ductus arteriosus</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Koyama, Norihisa ; Ogawa, Yunosuke ; Kamiya, Kenji ; Eguchi, Hideshi ; Tanaka, Taihei ; Takasaki, Jiro ; Ohama, Yoichi ; Itakura, Yukino ; Kaneko, Kohji</creator><creatorcontrib>Koyama, Norihisa ; Ogawa, Yunosuke ; Kamiya, Kenji ; Eguchi, Hideshi ; Tanaka, Taihei ; Takasaki, Jiro ; Ohama, Yoichi ; Itakura, Yukino ; Kaneko, Kohji</creatorcontrib><description>We investigated platelet-activating factor (PAF) in the tracheal aspirate from 3 intubated low birth weight infants with symptomatic patent ductus arteriosus (PDA). PAF increased with the onset of symptomatic PDA and decreased to the control range soon after the ductal closure. The concentration of PAF in 26 samples taken during symptomatic PDA (median 16 pg/μg lipid phosphorus, range 1.4–1,200 pg/μg lipid phosphorus) was significantly higher than that of 31 samples from the same three patients during the periods without symptomatic PDA (median 1.9 pg/μg lipid phosphorus, range 0–12 pg/μg lipid phosphorus;
P < 0.001). All 3 infants later developed chronic lung disease. These results suggest that large shunting PDA provokes PAF release to the air way of the neonate and that PAF might play a role in chronic lung disease developing after symptomatic PDA.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/0009-8981(93)90250-8</identifier><identifier>PMID: 8513570</identifier><identifier>CODEN: CCATAR</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Biological and medical sciences ; Bronchopulmonary dysplasia ; Cardiology. Vascular system ; Chronic lung disease ; Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava ; Ductus Arteriosus, Patent - metabolism ; Ductus Arteriosus, Patent - surgery ; Female ; Heart ; Humans ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Low birth weight infant ; Male ; Medical sciences ; Patent ductus arteriosus ; Platelet activating factor ; Platelet Activating Factor - metabolism ; Suction ; Trachea - metabolism ; Tracheal aspirate</subject><ispartof>Clinica chimica acta, 1993-04, Vol.215 (1), p.73-79</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-13c00154b564c99c452479123e69846a1650fb7b2c48b6099860883b1ed091c83</citedby><cites>FETCH-LOGICAL-c386t-13c00154b564c99c452479123e69846a1650fb7b2c48b6099860883b1ed091c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0009898193902508$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4744123$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8513570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koyama, Norihisa</creatorcontrib><creatorcontrib>Ogawa, Yunosuke</creatorcontrib><creatorcontrib>Kamiya, Kenji</creatorcontrib><creatorcontrib>Eguchi, Hideshi</creatorcontrib><creatorcontrib>Tanaka, Taihei</creatorcontrib><creatorcontrib>Takasaki, Jiro</creatorcontrib><creatorcontrib>Ohama, Yoichi</creatorcontrib><creatorcontrib>Itakura, Yukino</creatorcontrib><creatorcontrib>Kaneko, Kohji</creatorcontrib><title>Increased platelet activating factor in the tracheal aspirates from neonates with patent ductus arteriosus</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>We investigated platelet-activating factor (PAF) in the tracheal aspirate from 3 intubated low birth weight infants with symptomatic patent ductus arteriosus (PDA). PAF increased with the onset of symptomatic PDA and decreased to the control range soon after the ductal closure. The concentration of PAF in 26 samples taken during symptomatic PDA (median 16 pg/μg lipid phosphorus, range 1.4–1,200 pg/μg lipid phosphorus) was significantly higher than that of 31 samples from the same three patients during the periods without symptomatic PDA (median 1.9 pg/μg lipid phosphorus, range 0–12 pg/μg lipid phosphorus;
P < 0.001). All 3 infants later developed chronic lung disease. These results suggest that large shunting PDA provokes PAF release to the air way of the neonate and that PAF might play a role in chronic lung disease developing after symptomatic PDA.</description><subject>Biological and medical sciences</subject><subject>Bronchopulmonary dysplasia</subject><subject>Cardiology. Vascular system</subject><subject>Chronic lung disease</subject><subject>Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava</subject><subject>Ductus Arteriosus, Patent - metabolism</subject><subject>Ductus Arteriosus, Patent - surgery</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Low birth weight infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Patent ductus arteriosus</subject><subject>Platelet activating factor</subject><subject>Platelet Activating Factor - metabolism</subject><subject>Suction</subject><subject>Trachea - metabolism</subject><subject>Tracheal aspirate</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EKtvCG4DkA6rgELBjx7EvSKiitFIlLnC2nMmEdZVNgsdpxdvX213tkZNnNJ9_zXyMvZPisxTSfBFCuMo6Kz869cmJuhGVfcE20raqUtrVL9nmhLxm50T3pdXCyDN2ZhupmlZs2P3tBAkDYc-XMWQcMfMAOT6EHKc_fCj1nHiceN4izynAFsPIAy0xFZr4kOYdn3CenrvHmLd8KeWUeb9CXomHlDHFmVZ6w14NYSR8e3wv2O_r77-ubqq7nz9ur77dVaCsyZVUIIRsdNcYDc6BbmrdOlkrNM5qE6RpxNC1XQ3adkY4Z42wVnUSe-EkWHXBLg-5S5r_rkjZ7yIBjmMoe67k26a1tpa6gPoAQpqJEg5-SXEX0j8vhd8r9nt_fu_PO-WfFft9_vtj_trtsD99Ojot8w_HeSAI45DCBJFOmG61LtcU7OsBw-LiIWLyBBEnwD4mhOz7Of5_jyemSZfC</recordid><startdate>19930416</startdate><enddate>19930416</enddate><creator>Koyama, Norihisa</creator><creator>Ogawa, Yunosuke</creator><creator>Kamiya, Kenji</creator><creator>Eguchi, Hideshi</creator><creator>Tanaka, Taihei</creator><creator>Takasaki, Jiro</creator><creator>Ohama, Yoichi</creator><creator>Itakura, Yukino</creator><creator>Kaneko, Kohji</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930416</creationdate><title>Increased platelet activating factor in the tracheal aspirates from neonates with patent ductus arteriosus</title><author>Koyama, Norihisa ; Ogawa, Yunosuke ; Kamiya, Kenji ; Eguchi, Hideshi ; Tanaka, Taihei ; Takasaki, Jiro ; Ohama, Yoichi ; Itakura, Yukino ; Kaneko, Kohji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-13c00154b564c99c452479123e69846a1650fb7b2c48b6099860883b1ed091c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Biological and medical sciences</topic><topic>Bronchopulmonary dysplasia</topic><topic>Cardiology. Vascular system</topic><topic>Chronic lung disease</topic><topic>Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava</topic><topic>Ductus Arteriosus, Patent - metabolism</topic><topic>Ductus Arteriosus, Patent - surgery</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Low birth weight infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Patent ductus arteriosus</topic><topic>Platelet activating factor</topic><topic>Platelet Activating Factor - metabolism</topic><topic>Suction</topic><topic>Trachea - metabolism</topic><topic>Tracheal aspirate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koyama, Norihisa</creatorcontrib><creatorcontrib>Ogawa, Yunosuke</creatorcontrib><creatorcontrib>Kamiya, Kenji</creatorcontrib><creatorcontrib>Eguchi, Hideshi</creatorcontrib><creatorcontrib>Tanaka, Taihei</creatorcontrib><creatorcontrib>Takasaki, Jiro</creatorcontrib><creatorcontrib>Ohama, Yoichi</creatorcontrib><creatorcontrib>Itakura, Yukino</creatorcontrib><creatorcontrib>Kaneko, Kohji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koyama, Norihisa</au><au>Ogawa, Yunosuke</au><au>Kamiya, Kenji</au><au>Eguchi, Hideshi</au><au>Tanaka, Taihei</au><au>Takasaki, Jiro</au><au>Ohama, Yoichi</au><au>Itakura, Yukino</au><au>Kaneko, Kohji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased platelet activating factor in the tracheal aspirates from neonates with patent ductus arteriosus</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>1993-04-16</date><risdate>1993</risdate><volume>215</volume><issue>1</issue><spage>73</spage><epage>79</epage><pages>73-79</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><coden>CCATAR</coden><abstract>We investigated platelet-activating factor (PAF) in the tracheal aspirate from 3 intubated low birth weight infants with symptomatic patent ductus arteriosus (PDA). PAF increased with the onset of symptomatic PDA and decreased to the control range soon after the ductal closure. The concentration of PAF in 26 samples taken during symptomatic PDA (median 16 pg/μg lipid phosphorus, range 1.4–1,200 pg/μg lipid phosphorus) was significantly higher than that of 31 samples from the same three patients during the periods without symptomatic PDA (median 1.9 pg/μg lipid phosphorus, range 0–12 pg/μg lipid phosphorus;
P < 0.001). All 3 infants later developed chronic lung disease. These results suggest that large shunting PDA provokes PAF release to the air way of the neonate and that PAF might play a role in chronic lung disease developing after symptomatic PDA.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>8513570</pmid><doi>10.1016/0009-8981(93)90250-8</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-8981 |
| ispartof | Clinica chimica acta, 1993-04, Vol.215 (1), p.73-79 |
| issn | 0009-8981 1873-3492 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75788214 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biological and medical sciences Bronchopulmonary dysplasia Cardiology. Vascular system Chronic lung disease Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava Ductus Arteriosus, Patent - metabolism Ductus Arteriosus, Patent - surgery Female Heart Humans Infant Infant, Low Birth Weight Infant, Newborn Low birth weight infant Male Medical sciences Patent ductus arteriosus Platelet activating factor Platelet Activating Factor - metabolism Suction Trachea - metabolism Tracheal aspirate |
| title | Increased platelet activating factor in the tracheal aspirates from neonates with patent ductus arteriosus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T17%3A27%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20platelet%20activating%20factor%20in%20the%20tracheal%20aspirates%20from%20neonates%20with%20patent%20ductus%20arteriosus&rft.jtitle=Clinica%20chimica%20acta&rft.au=Koyama,%20Norihisa&rft.date=1993-04-16&rft.volume=215&rft.issue=1&rft.spage=73&rft.epage=79&rft.pages=73-79&rft.issn=0009-8981&rft.eissn=1873-3492&rft.coden=CCATAR&rft_id=info:doi/10.1016/0009-8981(93)90250-8&rft_dat=%3Cproquest_cross%3E75788214%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75788214&rft_id=info:pmid/8513570&rft_els_id=0009898193902508&rfr_iscdi=true |