Effects of pethidine, acetylsalicylic acid, and indomethacin on pain and behavior in the mole-rat
The antinociceptive and behavioral effects of pethidine (10, 20, or 30 mg/kg), acetylsalicylic acid (200, 400, or 600 mg/kg) and indomethacin (20, 40, or 50 mg/kg) in the naked mole-rat was studied in the hot-plate test. Instead of inducing analgesia, pethidine caused a dose-dependent reduction in r...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1993-05, Vol.45 (1), p.153-159 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Towett, Phelimon K. Kanui, Titus I. |
| description | The antinociceptive and behavioral effects of pethidine (10, 20, or 30 mg/kg), acetylsalicylic acid (200, 400, or 600 mg/kg) and indomethacin (20, 40, or 50 mg/kg) in the naked mole-rat was studied in the hot-plate test. Instead of inducing analgesia, pethidine caused a dose-dependent reduction in response latency. Sensorimotor impairment and aggressive behavior were also observed following administration of pethidine (20 or 30 mg/kg). All animals recieving pethidine (30 mg/kg) died following fighting when kept in colony cages. Aggressive behavior and death was prevented by naloxone or by keeping animals in single cages. Acetylsalicylic acid (600 mg/kg) and indomethacin (40 or 50 mg/kg) caused a significant increase in response latency. It is concluded that in the mole-rat pethidine elicits aggression, sensorimotor impairment, and apparent hypergesia. |
| doi_str_mv | 10.1016/0091-3057(93)90099-F |
| format | Article |
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Instead of inducing analgesia, pethidine caused a dose-dependent reduction in response latency. Sensorimotor impairment and aggressive behavior were also observed following administration of pethidine (20 or 30 mg/kg). All animals recieving pethidine (30 mg/kg) died following fighting when kept in colony cages. Aggressive behavior and death was prevented by naloxone or by keeping animals in single cages. Acetylsalicylic acid (600 mg/kg) and indomethacin (40 or 50 mg/kg) caused a significant increase in response latency. It is concluded that in the mole-rat pethidine elicits aggression, sensorimotor impairment, and apparent hypergesia.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(93)90099-F</identifier><identifier>PMID: 7639825</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aggression ; Aggression - drug effects ; Analgesics ; Analgesics - pharmacology ; Animals ; Aspirin - pharmacology ; Behavior, Animal - drug effects ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Hot-plate test ; Indomethacin - pharmacology ; Medical sciences ; Meperidine - pharmacology ; Naked mole-rat ; Naloxone - pharmacology ; Neuropharmacology ; Nociception ; NSAIDs ; Pain Measurement - drug effects ; Pethidine ; Pharmacology. 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Instead of inducing analgesia, pethidine caused a dose-dependent reduction in response latency. Sensorimotor impairment and aggressive behavior were also observed following administration of pethidine (20 or 30 mg/kg). All animals recieving pethidine (30 mg/kg) died following fighting when kept in colony cages. Aggressive behavior and death was prevented by naloxone or by keeping animals in single cages. Acetylsalicylic acid (600 mg/kg) and indomethacin (40 or 50 mg/kg) caused a significant increase in response latency. It is concluded that in the mole-rat pethidine elicits aggression, sensorimotor impairment, and apparent hypergesia.</description><subject>Aggression</subject><subject>Aggression - drug effects</subject><subject>Analgesics</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Aspirin - pharmacology</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Hot-plate test</subject><subject>Indomethacin - pharmacology</subject><subject>Medical sciences</subject><subject>Meperidine - pharmacology</subject><subject>Naked mole-rat</subject><subject>Naloxone - pharmacology</subject><subject>Neuropharmacology</subject><subject>Nociception</subject><subject>NSAIDs</subject><subject>Pain Measurement - drug effects</subject><subject>Pethidine</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychomotor Performance - drug effects</subject><subject>Reaction Time - drug effects</subject><subject>Rodentia</subject><subject>Sensorimotor impairment</subject><subject>Spalax ehrenbergi</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFq3DAQhkVJSTdp3yAFH0JJoG41lmXZl0IJ2SQQyCU9C1kasQq2tZW8gX37zHaXPTYHMczMNz-afxi7AP4DODQ_Oe-gFFyqq05cd5R15fIDW0CrRClBqRO2OCKf2FnOL5zzumrUKTtVjejaSi6YufUe7ZyL6Is1zqvgwoTfC2Nx3g7ZDMFu6VEeHFUnV4TJxZFAqkxFnIq1obhr9LgyryEmIop5hcUYByyTmT-zj94MGb8c4jn7s7x9vrkvH5_uHm5-P5a2BjWXqvJQq84B78EYj42TytEa3Ne-BYTWC6csryoO0nvRKwG99bKytiMBNOKcfdvrrlP8u8E86zFki8NgJoybrJVUbculfBeEpmkqVQOB9R60Keac0Ot1CqNJWw1c706gd_7qnb-6E_rfCfSSxr4e9Df9iO44dPCc-peHvsnWDD6ZyYZ8xGrarJWKsF97DMm014BJZxtwsuhCootpF8P___EGotWiKg</recordid><startdate>19930501</startdate><enddate>19930501</enddate><creator>Towett, Phelimon K.</creator><creator>Kanui, Titus I.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19930501</creationdate><title>Effects of pethidine, acetylsalicylic acid, and indomethacin on pain and behavior in the mole-rat</title><author>Towett, Phelimon K. ; Kanui, Titus I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-72f1479d10b1aafe6d57d5170f4f81e18f3d7c022015ff3b731bcf52cc9c41ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Aggression</topic><topic>Aggression - drug effects</topic><topic>Analgesics</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Aspirin - pharmacology</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>Hot-plate test</topic><topic>Indomethacin - pharmacology</topic><topic>Medical sciences</topic><topic>Meperidine - pharmacology</topic><topic>Naked mole-rat</topic><topic>Naloxone - pharmacology</topic><topic>Neuropharmacology</topic><topic>Nociception</topic><topic>NSAIDs</topic><topic>Pain Measurement - drug effects</topic><topic>Pethidine</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychomotor Performance - drug effects</topic><topic>Reaction Time - drug effects</topic><topic>Rodentia</topic><topic>Sensorimotor impairment</topic><topic>Spalax ehrenbergi</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Towett, Phelimon K.</creatorcontrib><creatorcontrib>Kanui, Titus I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Towett, Phelimon K.</au><au>Kanui, Titus I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of pethidine, acetylsalicylic acid, and indomethacin on pain and behavior in the mole-rat</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1993-05-01</date><risdate>1993</risdate><volume>45</volume><issue>1</issue><spage>153</spage><epage>159</epage><pages>153-159</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>The antinociceptive and behavioral effects of pethidine (10, 20, or 30 mg/kg), acetylsalicylic acid (200, 400, or 600 mg/kg) and indomethacin (20, 40, or 50 mg/kg) in the naked mole-rat was studied in the hot-plate test. Instead of inducing analgesia, pethidine caused a dose-dependent reduction in response latency. Sensorimotor impairment and aggressive behavior were also observed following administration of pethidine (20 or 30 mg/kg). All animals recieving pethidine (30 mg/kg) died following fighting when kept in colony cages. Aggressive behavior and death was prevented by naloxone or by keeping animals in single cages. Acetylsalicylic acid (600 mg/kg) and indomethacin (40 or 50 mg/kg) caused a significant increase in response latency. It is concluded that in the mole-rat pethidine elicits aggression, sensorimotor impairment, and apparent hypergesia.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>7639825</pmid><doi>10.1016/0091-3057(93)90099-F</doi><tpages>7</tpages></addata></record> |
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| ispartof | Pharmacology, biochemistry and behavior, 1993-05, Vol.45 (1), p.153-159 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aggression Aggression - drug effects Analgesics Analgesics - pharmacology Animals Aspirin - pharmacology Behavior, Animal - drug effects Biological and medical sciences Dose-Response Relationship, Drug Hot-plate test Indomethacin - pharmacology Medical sciences Meperidine - pharmacology Naked mole-rat Naloxone - pharmacology Neuropharmacology Nociception NSAIDs Pain Measurement - drug effects Pethidine Pharmacology. Drug treatments Psychomotor Performance - drug effects Reaction Time - drug effects Rodentia Sensorimotor impairment Spalax ehrenbergi |
| title | Effects of pethidine, acetylsalicylic acid, and indomethacin on pain and behavior in the mole-rat |
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