A double-blind trial of melatonin as a treatment for jet lag in international cabin crew
This study investigated the efficacy of oral melatonin in alleviating jet lag in flight crew after a series of international flights. The optimal time for taking melatonin in this group was also investigated. In a double-blind placebo-controlled trial, 52 international cabin crew were randomly assig...
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| Veröffentlicht in: | Biological psychiatry (1969) 1993-04, Vol.33 (7), p.526-530 |
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| container_end_page | 530 |
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| container_issue | 7 |
| container_start_page | 526 |
| container_title | Biological psychiatry (1969) |
| container_volume | 33 |
| creator | Petrie, Keith Dawson, Alexander G. Thompson, Leonard Brook, Richard |
| description | This study investigated the efficacy of oral melatonin in alleviating jet lag in flight crew after a series of international flights. The optimal time for taking melatonin in this group was also investigated. In a double-blind placebo-controlled trial, 52 international cabin crew were randomly assigned to three groups; early melatonin (5 mg started 3 days prior to arrival until 5 days after return home); late melatonin (placebo for 3 days then 5 mg melatonin for 5 days); and placebo. Daily ratings showed a trend in jet lag, mood, and sleepiness measures toward an improved recovery in the late melatonin group and a worse recovery in the early melatonin group as compared to placebo. Retrospective ratings made 6 days after arrival showed the late melatonin group reported significantly less jet lag and sleep disturbance following the flight compared to placebo. The late melatonin group also showed a significantly faster recovery of energy and alertness than the early melatonin group, which reported a worse overall recovery than placebo. These findings show melatonin may have potential benefits for international aircrew. |
| doi_str_mv | 10.1016/0006-3223(93)90007-Z |
| format | Article |
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The optimal time for taking melatonin in this group was also investigated. In a double-blind placebo-controlled trial, 52 international cabin crew were randomly assigned to three groups; early melatonin (5 mg started 3 days prior to arrival until 5 days after return home); late melatonin (placebo for 3 days then 5 mg melatonin for 5 days); and placebo. Daily ratings showed a trend in jet lag, mood, and sleepiness measures toward an improved recovery in the late melatonin group and a worse recovery in the early melatonin group as compared to placebo. Retrospective ratings made 6 days after arrival showed the late melatonin group reported significantly less jet lag and sleep disturbance following the flight compared to placebo. The late melatonin group also showed a significantly faster recovery of energy and alertness than the early melatonin group, which reported a worse overall recovery than placebo. These findings show melatonin may have potential benefits for international aircrew.</description><subject>Adult</subject><subject>air crew</subject><subject>Biological and medical sciences</subject><subject>Circadian Rhythm - drug effects</subject><subject>circadian rhythms</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>jet-lag</subject><subject>Male</subject><subject>Medical sciences</subject><subject>melatonin</subject><subject>Melatonin - therapeutic use</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>sleep</subject><subject>Space Flight</subject><subject>Space life sciences</subject><subject>Travel</subject><subject>Work Schedule Tolerance</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM2KFDEUhYMoYzv6BgpZiOiiNH9dqdoIw-AfDLhRkNmEW8mNZEglY5JWfHtTdNNLIRByz3cP4SPkOWdvOePjO8bYOEgh5OtZvpn7Sw-3D8iOT1oOQjHxkOzOyGPypNa7jRGCX5CLac8lk3pHflxRlw9LxGGJITnaSoBIs6crRmg5hUShUuhzhLZiatTnQu-w0Qg_aU9DalgStJBTX7Sw9Jkt-OcpeeQhVnx2ui_J948fvl1_Hm6-fvpyfXUzWDmNbXDcCie95eDtOHutrBoFaJyVnkbUsxfcTU7ZxTs76RmsYns2M4BJcaZnLi_Jq2Pvfcm_DlibWUO1GCMkzIdq9L4X8ZF1UB1BW3KtBb25L2GF8tdwZjahZrNlNltm7meTZW772otT_2FZ0Z2XTgZ7_vKUQ7UQfYFkQz1jSqv9KEXH3h8x7C5-Byym2oDJogsFbTMuh___4x-fMZE4</recordid><startdate>19930401</startdate><enddate>19930401</enddate><creator>Petrie, Keith</creator><creator>Dawson, Alexander G.</creator><creator>Thompson, Leonard</creator><creator>Brook, Richard</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930401</creationdate><title>A double-blind trial of melatonin as a treatment for jet lag in international cabin crew</title><author>Petrie, Keith ; Dawson, Alexander G. ; Thompson, Leonard ; Brook, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-d1c2d3fc1afc69f74c462a7e94786e79f21d8d4cbfdc879ac405090aa84107913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>air crew</topic><topic>Biological and medical sciences</topic><topic>Circadian Rhythm - drug effects</topic><topic>circadian rhythms</topic><topic>Double-Blind Method</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>jet-lag</topic><topic>Male</topic><topic>Medical sciences</topic><topic>melatonin</topic><topic>Melatonin - therapeutic use</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>sleep</topic><topic>Space Flight</topic><topic>Space life sciences</topic><topic>Travel</topic><topic>Work Schedule Tolerance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petrie, Keith</creatorcontrib><creatorcontrib>Dawson, Alexander G.</creatorcontrib><creatorcontrib>Thompson, Leonard</creatorcontrib><creatorcontrib>Brook, Richard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petrie, Keith</au><au>Dawson, Alexander G.</au><au>Thompson, Leonard</au><au>Brook, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A double-blind trial of melatonin as a treatment for jet lag in international cabin crew</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>1993-04-01</date><risdate>1993</risdate><volume>33</volume><issue>7</issue><spage>526</spage><epage>530</epage><pages>526-530</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>This study investigated the efficacy of oral melatonin in alleviating jet lag in flight crew after a series of international flights. The optimal time for taking melatonin in this group was also investigated. In a double-blind placebo-controlled trial, 52 international cabin crew were randomly assigned to three groups; early melatonin (5 mg started 3 days prior to arrival until 5 days after return home); late melatonin (placebo for 3 days then 5 mg melatonin for 5 days); and placebo. Daily ratings showed a trend in jet lag, mood, and sleepiness measures toward an improved recovery in the late melatonin group and a worse recovery in the early melatonin group as compared to placebo. Retrospective ratings made 6 days after arrival showed the late melatonin group reported significantly less jet lag and sleep disturbance following the flight compared to placebo. The late melatonin group also showed a significantly faster recovery of energy and alertness than the early melatonin group, which reported a worse overall recovery than placebo. These findings show melatonin may have potential benefits for international aircrew.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8513037</pmid><doi>10.1016/0006-3223(93)90007-Z</doi><tpages>5</tpages></addata></record> |
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| ispartof | Biological psychiatry (1969), 1993-04, Vol.33 (7), p.526-530 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult air crew Biological and medical sciences Circadian Rhythm - drug effects circadian rhythms Double-Blind Method Drug Administration Schedule Female Hormones. Endocrine system Humans jet-lag Male Medical sciences melatonin Melatonin - therapeutic use Middle Aged Pharmacology. Drug treatments sleep Space Flight Space life sciences Travel Work Schedule Tolerance |
| title | A double-blind trial of melatonin as a treatment for jet lag in international cabin crew |
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