The human muscarinic M1 acetylcholine receptor, when express in CHO cells, activates and downregulates both Gq alpha and G11 alpha equally and non-selectively

CHO cells express both of the phosphoinositidase C-linked G-proteins Gq and G11. G11 alpha is some 2.5-fold more highly expressed than Gq alpha in membranes of these cells. Following transfection and stable expression of CHO cells with DNA encoding the human muscarinic M1 acetylcholine (HM1) recepto...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	FEBS letters 1993-06, Vol.324 (2), p.241-245
Hauptverfasser:	Mullaney, I, Mitchell, F M, McCallum, J F, Buckley, N J, Milligan, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbachol - pharmacology CHO Cells Cricetinae Dose-Response Relationship, Drug Down-Regulation GTP-Binding Proteins - classification GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Humans Receptors, Muscarinic - genetics Receptors, Muscarinic - metabolism Recombinant Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!