Hepatitis C is a poor prognostic indicator in black kidney transplant recipients
The significance of hepatitis C in kidney transplant recipients is unclear. The prevalence of antibodies to hepatitis C among candidates for transplantation is up to 50% in some centers. We screened 640 frozen serum samples obtained pretransplantation from all kidney recipients at the Medical Colleg...
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| Veröffentlicht in: | Transplantation 1993-06, Vol.55 (6), p.1283-1287 |
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| container_title | Transplantation |
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| creator | FRITSCHE, C BRANDES, J. C DELANEY, S. R GALLAGHER-LEPAK, S MENITOVE, J. E RICH, L SCANNELL, C SWANSON, P LEE, H. H |
| description | The significance of hepatitis C in kidney transplant recipients is unclear. The prevalence of antibodies to hepatitis C among candidates for transplantation is up to 50% in some centers.
We screened 640 frozen serum samples obtained pretransplantation from all kidney recipients at the Medical College of Wisconsin between January 1979 and March 1990 for antibody to hepatitis C using the second generation immunoassay. Charts were reviewed from all hepatitis C antibody-positive (anti-HCV+) patients and 256 randomly chosen hepatitis C antibody negative (anti-HCV-) controls. Actuarial patient and graft survival in these two groups were determined.
The prevalence of anti-HCV was 8.3%. Blacks and i.v. drug users were disproportionately represented in the anti-HCV+ group. Of the anti-HCV+ patients, 18.9% developed chronic hepatitis independent of race. Black anti-HCV+ patients had a 5-year graft survival of 28 +/- 11% compared to 67 +/- 7% in black anti-HCV- patients (P = 0.003). Black anti-HCV-, white anti-HCV-, and white anti-HCV+ patients all had similar graft survival. Anti-HCV was not a poor prognostic indicator for overall patient survival or the development of aplastic anemia and malignancies including hepatocellular carcinoma.
Anti-HCV is a significant risk factor for reduced kidney graft survival in blacks apart from i.v. drug abuse. Black anti-HCV- patients had graft survival similar to white transplant recipients, indicating that anti-HCV may be one marker for the poorer graft survival in blacks that has been observed in most transplant programs. Anti-HCV in kidney transplant recipients increases the risk for the development of chronic hepatitis post-transplant. |
| doi_str_mv | 10.1097/00007890-199306000-00014 |
| format | Article |
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We screened 640 frozen serum samples obtained pretransplantation from all kidney recipients at the Medical College of Wisconsin between January 1979 and March 1990 for antibody to hepatitis C using the second generation immunoassay. Charts were reviewed from all hepatitis C antibody-positive (anti-HCV+) patients and 256 randomly chosen hepatitis C antibody negative (anti-HCV-) controls. Actuarial patient and graft survival in these two groups were determined.
The prevalence of anti-HCV was 8.3%. Blacks and i.v. drug users were disproportionately represented in the anti-HCV+ group. Of the anti-HCV+ patients, 18.9% developed chronic hepatitis independent of race. Black anti-HCV+ patients had a 5-year graft survival of 28 +/- 11% compared to 67 +/- 7% in black anti-HCV- patients (P = 0.003). Black anti-HCV-, white anti-HCV-, and white anti-HCV+ patients all had similar graft survival. Anti-HCV was not a poor prognostic indicator for overall patient survival or the development of aplastic anemia and malignancies including hepatocellular carcinoma.
Anti-HCV is a significant risk factor for reduced kidney graft survival in blacks apart from i.v. drug abuse. Black anti-HCV- patients had graft survival similar to white transplant recipients, indicating that anti-HCV may be one marker for the poorer graft survival in blacks that has been observed in most transplant programs. Anti-HCV in kidney transplant recipients increases the risk for the development of chronic hepatitis post-transplant.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-199306000-00014</identifier><identifier>PMID: 8516814</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adult ; African Americans ; Biological and medical sciences ; Female ; Graft Survival ; Hepatitis Antibodies - analysis ; Hepatitis C - complications ; hepatitis C virus ; Humans ; Kidney Transplantation ; Liver, biliary tract, pancreas, portal circulation, spleen ; Male ; Medical sciences ; Neoplasms - complications ; Prognosis ; Retrospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Survival Analysis</subject><ispartof>Transplantation, 1993-06, Vol.55 (6), p.1283-1287</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-c968852d2ba4b4f620470ebb9a0c878f531f90a2e4c0af8b5695b43c9e8af9593</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4830342$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8516814$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FRITSCHE, C</creatorcontrib><creatorcontrib>BRANDES, J. C</creatorcontrib><creatorcontrib>DELANEY, S. R</creatorcontrib><creatorcontrib>GALLAGHER-LEPAK, S</creatorcontrib><creatorcontrib>MENITOVE, J. E</creatorcontrib><creatorcontrib>RICH, L</creatorcontrib><creatorcontrib>SCANNELL, C</creatorcontrib><creatorcontrib>SWANSON, P</creatorcontrib><creatorcontrib>LEE, H. H</creatorcontrib><title>Hepatitis C is a poor prognostic indicator in black kidney transplant recipients</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>The significance of hepatitis C in kidney transplant recipients is unclear. The prevalence of antibodies to hepatitis C among candidates for transplantation is up to 50% in some centers.
We screened 640 frozen serum samples obtained pretransplantation from all kidney recipients at the Medical College of Wisconsin between January 1979 and March 1990 for antibody to hepatitis C using the second generation immunoassay. Charts were reviewed from all hepatitis C antibody-positive (anti-HCV+) patients and 256 randomly chosen hepatitis C antibody negative (anti-HCV-) controls. Actuarial patient and graft survival in these two groups were determined.
The prevalence of anti-HCV was 8.3%. Blacks and i.v. drug users were disproportionately represented in the anti-HCV+ group. Of the anti-HCV+ patients, 18.9% developed chronic hepatitis independent of race. Black anti-HCV+ patients had a 5-year graft survival of 28 +/- 11% compared to 67 +/- 7% in black anti-HCV- patients (P = 0.003). Black anti-HCV-, white anti-HCV-, and white anti-HCV+ patients all had similar graft survival. Anti-HCV was not a poor prognostic indicator for overall patient survival or the development of aplastic anemia and malignancies including hepatocellular carcinoma.
Anti-HCV is a significant risk factor for reduced kidney graft survival in blacks apart from i.v. drug abuse. Black anti-HCV- patients had graft survival similar to white transplant recipients, indicating that anti-HCV may be one marker for the poorer graft survival in blacks that has been observed in most transplant programs. Anti-HCV in kidney transplant recipients increases the risk for the development of chronic hepatitis post-transplant.</description><subject>Adult</subject><subject>African Americans</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Graft Survival</subject><subject>Hepatitis Antibodies - analysis</subject><subject>Hepatitis C - complications</subject><subject>hepatitis C virus</subject><subject>Humans</subject><subject>Kidney Transplantation</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasms - complications</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Survival Analysis</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFPwyAUgInRzDn9CSYcjLfqo0CBo1nUmSzRg54boNTgurYCO_jvRVd3lQTI432P9_IhhAncEFDiFvISUkFBlKJQ5ajIm7AjNCecsqICCcdoDsBIQSgVp-gsxo-McCrEDM0kJ5UkbI5eVm7UyScf8RLnQ-NxGAIew_DeDzF5i33feKtTfvQ9Np22G7zxTe--cAq6j2On-4SDs370rk_xHJ20uovuYroX6O3h_nW5KtbPj0_Lu3VhWQmpsKqSkpdNaTQzrK1KYAKcMUqDlUK2nJJWgS4ds6BbaXiluGHUKid1q7iiC3S9_zeP-rlzMdVbH63r8jhu2MVacCG5IuRfMIsQouQig3IP2jDEGFxbj8FvdfiqCdQ_1us_6_XBev1rPZdeTj12ZuuaQ-GkOeevpryOVndtFmd9PGBMUqCspN_8v4mY</recordid><startdate>19930601</startdate><enddate>19930601</enddate><creator>FRITSCHE, C</creator><creator>BRANDES, J. C</creator><creator>DELANEY, S. R</creator><creator>GALLAGHER-LEPAK, S</creator><creator>MENITOVE, J. E</creator><creator>RICH, L</creator><creator>SCANNELL, C</creator><creator>SWANSON, P</creator><creator>LEE, H. H</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19930601</creationdate><title>Hepatitis C is a poor prognostic indicator in black kidney transplant recipients</title><author>FRITSCHE, C ; BRANDES, J. C ; DELANEY, S. R ; GALLAGHER-LEPAK, S ; MENITOVE, J. E ; RICH, L ; SCANNELL, C ; SWANSON, P ; LEE, H. H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-c968852d2ba4b4f620470ebb9a0c878f531f90a2e4c0af8b5695b43c9e8af9593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>African Americans</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Graft Survival</topic><topic>Hepatitis Antibodies - analysis</topic><topic>Hepatitis C - complications</topic><topic>hepatitis C virus</topic><topic>Humans</topic><topic>Kidney Transplantation</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neoplasms - complications</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FRITSCHE, C</creatorcontrib><creatorcontrib>BRANDES, J. C</creatorcontrib><creatorcontrib>DELANEY, S. R</creatorcontrib><creatorcontrib>GALLAGHER-LEPAK, S</creatorcontrib><creatorcontrib>MENITOVE, J. E</creatorcontrib><creatorcontrib>RICH, L</creatorcontrib><creatorcontrib>SCANNELL, C</creatorcontrib><creatorcontrib>SWANSON, P</creatorcontrib><creatorcontrib>LEE, H. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FRITSCHE, C</au><au>BRANDES, J. C</au><au>DELANEY, S. R</au><au>GALLAGHER-LEPAK, S</au><au>MENITOVE, J. E</au><au>RICH, L</au><au>SCANNELL, C</au><au>SWANSON, P</au><au>LEE, H. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis C is a poor prognostic indicator in black kidney transplant recipients</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>1993-06-01</date><risdate>1993</risdate><volume>55</volume><issue>6</issue><spage>1283</spage><epage>1287</epage><pages>1283-1287</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>The significance of hepatitis C in kidney transplant recipients is unclear. The prevalence of antibodies to hepatitis C among candidates for transplantation is up to 50% in some centers.
We screened 640 frozen serum samples obtained pretransplantation from all kidney recipients at the Medical College of Wisconsin between January 1979 and March 1990 for antibody to hepatitis C using the second generation immunoassay. Charts were reviewed from all hepatitis C antibody-positive (anti-HCV+) patients and 256 randomly chosen hepatitis C antibody negative (anti-HCV-) controls. Actuarial patient and graft survival in these two groups were determined.
The prevalence of anti-HCV was 8.3%. Blacks and i.v. drug users were disproportionately represented in the anti-HCV+ group. Of the anti-HCV+ patients, 18.9% developed chronic hepatitis independent of race. Black anti-HCV+ patients had a 5-year graft survival of 28 +/- 11% compared to 67 +/- 7% in black anti-HCV- patients (P = 0.003). Black anti-HCV-, white anti-HCV-, and white anti-HCV+ patients all had similar graft survival. Anti-HCV was not a poor prognostic indicator for overall patient survival or the development of aplastic anemia and malignancies including hepatocellular carcinoma.
Anti-HCV is a significant risk factor for reduced kidney graft survival in blacks apart from i.v. drug abuse. Black anti-HCV- patients had graft survival similar to white transplant recipients, indicating that anti-HCV may be one marker for the poorer graft survival in blacks that has been observed in most transplant programs. Anti-HCV in kidney transplant recipients increases the risk for the development of chronic hepatitis post-transplant.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>8516814</pmid><doi>10.1097/00007890-199306000-00014</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult African Americans Biological and medical sciences Female Graft Survival Hepatitis Antibodies - analysis Hepatitis C - complications hepatitis C virus Humans Kidney Transplantation Liver, biliary tract, pancreas, portal circulation, spleen Male Medical sciences Neoplasms - complications Prognosis Retrospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Survival Analysis |
| title | Hepatitis C is a poor prognostic indicator in black kidney transplant recipients |
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