Cholinergic marker deficits induced by lesions of the nucleus basalis of Meynert are attenuated by nerve growth factor in young, but not in aged, F344 rats

To investigate the efficacy of nerve growth factor (NGF) in promoting recovery from cholinergic damage, young (3–4 month old) and aged (22–23 month old) Fischer 344 rats received NMDA-induced unilateral lesions of the nucleus basalis of Meynert and subcutaneous osmotic pumps (2-week duration) connec...

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Veröffentlicht in:	Brain research 1993-04, Vol.609 (1), p.327-332
Hauptverfasser:	Santucci, Anthony C., Kanof, Philip D., Haroutunian, Varham
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - metabolism Aging Aging - physiology Animals Biological and medical sciences Biomarkers Choline acetyltransferase Choline O-Acetyltransferase - metabolism Male Medical sciences Miscellaneous Nerve growth factor Nerve Growth Factors - pharmacology Neuropharmacology Nucleus basalis of Meynert Parasympathetic Nervous System - cytology Parasympathetic Nervous System - physiology Pharmacology. Drug treatments Rats Rats, Inbred F344 Substantia Innominata - physiology
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