Sequential monitoring of clinical trials: The role of information and brownian motion

Sequential monitoring has been a topic of major interest in clinical trials methodology over the past two decades. This paper presents a unified conceptual framework for sequential monitoring that covers a wide variety of monitoring procedures in a wide variety of clinical trial settings. The centra...

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Veröffentlicht in:	Statistics in medicine 1993-04, Vol.12 (8), p.753-765
Hauptverfasser:	Lan, K. K. Gordon, Zucker, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biophysical Phenomena Biophysics Clinical Protocols Clinical Trials as Topic Data Interpretation, Statistical Humans Likelihood Functions Linear Models Proportional Hazards Models Random Allocation Research Design Stochastic Processes Survival Rate Time Factors
Online-Zugang:	Volltext
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