Acidic furo[3,2-b]indoles. A new series of potent antiallergy agents

A series of furo[3,2-b]indole carboxylic acids, tetrazoles, and carbamoyltetrazoles was prepared and tested in vitro with use of a model of active pulmonary anaphylaxis, the modified Schultz-Dale Test (SDT). In this model, isolated guinea pig lung strips are repeatedly challenged with antigen in the...

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Veröffentlicht in:	Journal of medicinal chemistry 1984-12, Vol.27 (12), p.1629-1633
Hauptverfasser:	Unangst, P C, Carethers, M E, Webster, K, Janik, G M, Robichaud, L J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemical Phenomena Chemistry Drug Evaluation, Preclinical Furans - chemical synthesis Furans - pharmacology Guinea Pigs Histamine H1 Antagonists - chemical synthesis In Vitro Techniques Indicators and Reagents Indoles - chemical synthesis Indoles - pharmacology Lung - drug effects Magnetic Resonance Spectroscopy Male Ovalbumin Pyrilamine - pharmacology Structure-Activity Relationship
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