T-cell-mediated response in Dupuytren's disease
The cause of Dupuytren's disease is unknown, but inflammatory cells might have a role. Enzymatic digestion of diseased tissue permits identification and immunofluorescent labelling of a cell subset displaying inflammatory cell morphology. Cytofluorimetry of this cell population demonstrated the...
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| Veröffentlicht in: | The Lancet (British edition) 1993-06, Vol.341 (8861), p.1622-1623 |
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| creator | Baird, K.S Crossan, J.F Alwan, W.H Wojciak, B |
| description | The cause of Dupuytren's disease is unknown, but inflammatory cells might have a role. Enzymatic digestion of diseased tissue permits identification and immunofluorescent labelling of a cell subset displaying inflammatory cell morphology. Cytofluorimetry of this cell population demonstrated the presence of CD3-positive lymphocytes and expression of major histocompatibility complex (MHC) class II proteins. These results raise the possibility that Dupuytren's disease is a T-cell-mediated autoimmune disorder. The development of medical treatment on this basis may reduce the need for surgery, with its associated morbidity and high recurrence rates. |
| doi_str_mv | 10.1016/0140-6736(93)90760-E |
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Enzymatic digestion of diseased tissue permits identification and immunofluorescent labelling of a cell subset displaying inflammatory cell morphology. Cytofluorimetry of this cell population demonstrated the presence of CD3-positive lymphocytes and expression of major histocompatibility complex (MHC) class II proteins. These results raise the possibility that Dupuytren's disease is a T-cell-mediated autoimmune disorder. The development of medical treatment on this basis may reduce the need for surgery, with its associated morbidity and high recurrence rates.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/0140-6736(93)90760-E</identifier><identifier>PMID: 8099992</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; CD4-Positive T-Lymphocytes - immunology ; Cell morphology ; Disease ; Diseases of the osteoarticular system ; Dupuytren Contracture - immunology ; Dupuytren Contracture - pathology ; Fascia - immunology ; Female ; Fibroblasts - immunology ; HLA-DR Antigens - immunology ; Humans ; Immunity (Disease) ; Juxtaarticular diseases. 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Enzymatic digestion of diseased tissue permits identification and immunofluorescent labelling of a cell subset displaying inflammatory cell morphology. Cytofluorimetry of this cell population demonstrated the presence of CD3-positive lymphocytes and expression of major histocompatibility complex (MHC) class II proteins. These results raise the possibility that Dupuytren's disease is a T-cell-mediated autoimmune disorder. The development of medical treatment on this basis may reduce the need for surgery, with its associated morbidity and high recurrence rates.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Cell morphology</subject><subject>Disease</subject><subject>Diseases of the osteoarticular system</subject><subject>Dupuytren Contracture - immunology</subject><subject>Dupuytren Contracture - pathology</subject><subject>Fascia - immunology</subject><subject>Female</subject><subject>Fibroblasts - immunology</subject><subject>HLA-DR Antigens - immunology</subject><subject>Humans</subject><subject>Immunity (Disease)</subject><subject>Juxtaarticular diseases. Extraarticular rhumatism</subject><subject>Lymphocytes</subject><subject>Macrophages - immunology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gUIR8eOwNskm2eQiSK0fUPBSwVvIJlNIaXdrsiv035u1pQcPzmUO88zMy4PQOcH3BBMxwoThTBS5uFX5ncKFwNnkAPUJK1jGWfF5iPp75BidxLjAGDOBeQ_1JFapaB-NZpmF5TJbgfOmATcMENd1FWHoq-FTu243TYDqJg6dj2AinKKjuVlGONv1Afp4nszGr9n0_eVt_DjNLCN5kwkhXZ4eQJlzKudABOeOCidSSmaUlUxZiw0pqROy4MQ47lTuGCe0JCXwfICut3fXof5qITZ65WOX1FRQt1EXvJCUFjiBl3_ARd2GKmXTREklKRY0QWwL2VDHGGCu18GvTNhognUnU3emdGdKq1z_ytSTtHaxu92WSdB-aWcvza92cxOtWc6DqayPe4xJghXtIj5sMUjCvj0EHa2HyiblAWyjXe3_z_EDgIGNfA</recordid><startdate>19930626</startdate><enddate>19930626</enddate><creator>Baird, K.S</creator><creator>Crossan, J.F</creator><creator>Alwan, W.H</creator><creator>Wojciak, B</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>19930626</creationdate><title>T-cell-mediated response in Dupuytren's disease</title><author>Baird, K.S ; Crossan, J.F ; Alwan, W.H ; Wojciak, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-668d3992eb3528fe1655d26d67604a9c849cc0a1b2d68751ad5d93d4512b1be53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Cell morphology</topic><topic>Disease</topic><topic>Diseases of the osteoarticular system</topic><topic>Dupuytren Contracture - immunology</topic><topic>Dupuytren Contracture - pathology</topic><topic>Fascia - immunology</topic><topic>Female</topic><topic>Fibroblasts - immunology</topic><topic>HLA-DR Antigens - immunology</topic><topic>Humans</topic><topic>Immunity (Disease)</topic><topic>Juxtaarticular diseases. 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Enzymatic digestion of diseased tissue permits identification and immunofluorescent labelling of a cell subset displaying inflammatory cell morphology. Cytofluorimetry of this cell population demonstrated the presence of CD3-positive lymphocytes and expression of major histocompatibility complex (MHC) class II proteins. These results raise the possibility that Dupuytren's disease is a T-cell-mediated autoimmune disorder. The development of medical treatment on this basis may reduce the need for surgery, with its associated morbidity and high recurrence rates.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>8099992</pmid><doi>10.1016/0140-6736(93)90760-E</doi><tpages>2</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Cell morphology Disease Diseases of the osteoarticular system Dupuytren Contracture - immunology Dupuytren Contracture - pathology Fascia - immunology Female Fibroblasts - immunology HLA-DR Antigens - immunology Humans Immunity (Disease) Juxtaarticular diseases. Extraarticular rhumatism Lymphocytes Macrophages - immunology Male Medical research Medical sciences Medical treatment Middle Aged T-Lymphocytes - immunology T-Lymphocytes, Cytotoxic - immunology |
| title | T-cell-mediated response in Dupuytren's disease |
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