Lipoprotein(a) plasma concentrations associated with lipolytic activities in eight kindreds with familial combined hyperlipidemia and normolipidemic subjects
The relationship between lipoprotein(a) [Lp(a)] and metabolism of triglyceride-rich lipoproteins (TRL) was studied in 58 untreated patients with familial combined hyperlipidemia (FCH) from eight different kindreds, 17 spouse controls, and 17 unrelated controls. Lp(a) plasma concentrations were not s...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 1993-06, Vol.42 (6), p.756-761 |
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| container_title | Metabolism, clinical and experimental |
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| creator | Cabezas, Manuel Castro de Bruin, Tjerk W.A. Van Linde-Sibenius Trip, Margreet Kock, Luciënne A.W. Jansen, Hans Erkelens, D.Willem |
| description | The relationship between lipoprotein(a) [Lp(a)] and metabolism of triglyceride-rich lipoproteins (TRL) was studied in 58 untreated patients with familial combined hyperlipidemia (FCH) from eight different kindreds, 17 spouse controls, and 17 unrelated controls. Lp(a) plasma concentrations were not significantly different between FCH subjects (343 ± 61 mg/L, mean ± SEM) and controls (249 ± 52 mg/L). In FCH, log-transformed Lp(a) levels correlated positively with postheparin lipoprotein lipase ([LPL]
r = .61,
P = .0002) and hepatic lipase ([HL]
r = .46,
P = .008) activities and total plasma cholesterol level (
r = .30,
P = .03). In controls, Lp(a) correlated with LPL (
r = .50,
P = .04) and total plasma cholesterol level (
r = .51,
P = .003). In eight FCH patients, treatment with the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor simvastatin resulted in significantly increased mean LPL activities and plasma Lp(a) concentrations. In three of these FCH patients, repeated measurements during 1 year demonstrated that changes in Lp(a) concentrations were paralleled by similar changes in LPL activity, but not HL activity. The observed correlation between postheparin plasma lipolytic activities and Lp(a) plasma concentrations suggests a connection between the metabolism of TRL and Lp(a). |
| doi_str_mv | 10.1016/0026-0495(93)90245-J |
| format | Article |
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r = .61,
P = .0002) and hepatic lipase ([HL]
r = .46,
P = .008) activities and total plasma cholesterol level (
r = .30,
P = .03). In controls, Lp(a) correlated with LPL (
r = .50,
P = .04) and total plasma cholesterol level (
r = .51,
P = .003). In eight FCH patients, treatment with the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor simvastatin resulted in significantly increased mean LPL activities and plasma Lp(a) concentrations. In three of these FCH patients, repeated measurements during 1 year demonstrated that changes in Lp(a) concentrations were paralleled by similar changes in LPL activity, but not HL activity. The observed correlation between postheparin plasma lipolytic activities and Lp(a) plasma concentrations suggests a connection between the metabolism of TRL and Lp(a).</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/0026-0495(93)90245-J</identifier><identifier>PMID: 8510521</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>ACTIVIDAD ENZIMATICA ; ACTIVITE ENZYMATIQUE ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; BLOOD LIPIDS ; ENZYMIC ACTIVITY ; FAMILIA ; FAMILIAL INCIDENCE ; FAMILIES ; FAMILLE ; Fatty Acids - physiology ; Female ; FOIE ; Heparin - administration & dosage ; Heparin - pharmacology ; HIGADO ; Humans ; HYPERLIPEMIA ; Hyperlipidemia, Familial Combined - blood ; Hyperlipidemia, Familial Combined - drug therapy ; Hyperlipidemia, Familial Combined - metabolism ; Hypolipidemic Agents - therapeutic use ; Injections, Intravenous ; LIPAEMIA ; Lipase - drug effects ; Lipase - metabolism ; LIPEMIA ; LIPEMIE ; LIPOLISIS ; LIPOLYSE ; LIPOLYSIS ; Lipolysis - physiology ; LIPOPROTEIN LIPASE ; Lipoprotein(a) - blood ; LIPOPROTEINA LIPASA ; LIPOPROTEINAS ; LIPOPROTEINE ; LIPOPROTEINE LIPASE ; LIPOPROTEINS ; LIVER ; Lovastatin - analogs & derivatives ; Lovastatin - therapeutic use ; Male ; Medical sciences ; Metabolic diseases ; METABOLIC DISORDERS ; Middle Aged ; Obesity ; Simvastatin ; Time Factors ; TRASTORNOS METABOLICOS ; TRIACILGLICEROL LIPASA ; TRIACYLGLYCEROL LIPASE ; triacylglycerol-rich lipoproteins ; TROUBLE DU METABOLISME</subject><ispartof>Metabolism, clinical and experimental, 1993-06, Vol.42 (6), p.756-761</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-fd395fbb871500749bb9082061d3c1e45a6abbc493eaac44b94515ddbe3c93d63</citedby><cites>FETCH-LOGICAL-c320t-fd395fbb871500749bb9082061d3c1e45a6abbc493eaac44b94515ddbe3c93d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0026-0495(93)90245-J$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4857293$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8510521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cabezas, Manuel Castro</creatorcontrib><creatorcontrib>de Bruin, Tjerk W.A.</creatorcontrib><creatorcontrib>Van Linde-Sibenius Trip, Margreet</creatorcontrib><creatorcontrib>Kock, Luciënne A.W.</creatorcontrib><creatorcontrib>Jansen, Hans</creatorcontrib><creatorcontrib>Erkelens, D.Willem</creatorcontrib><title>Lipoprotein(a) plasma concentrations associated with lipolytic activities in eight kindreds with familial combined hyperlipidemia and normolipidemic subjects</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>The relationship between lipoprotein(a) [Lp(a)] and metabolism of triglyceride-rich lipoproteins (TRL) was studied in 58 untreated patients with familial combined hyperlipidemia (FCH) from eight different kindreds, 17 spouse controls, and 17 unrelated controls. Lp(a) plasma concentrations were not significantly different between FCH subjects (343 ± 61 mg/L, mean ± SEM) and controls (249 ± 52 mg/L). In FCH, log-transformed Lp(a) levels correlated positively with postheparin lipoprotein lipase ([LPL]
r = .61,
P = .0002) and hepatic lipase ([HL]
r = .46,
P = .008) activities and total plasma cholesterol level (
r = .30,
P = .03). In controls, Lp(a) correlated with LPL (
r = .50,
P = .04) and total plasma cholesterol level (
r = .51,
P = .003). In eight FCH patients, treatment with the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor simvastatin resulted in significantly increased mean LPL activities and plasma Lp(a) concentrations. In three of these FCH patients, repeated measurements during 1 year demonstrated that changes in Lp(a) concentrations were paralleled by similar changes in LPL activity, but not HL activity. The observed correlation between postheparin plasma lipolytic activities and Lp(a) plasma concentrations suggests a connection between the metabolism of TRL and Lp(a).</description><subject>ACTIVIDAD ENZIMATICA</subject><subject>ACTIVITE ENZYMATIQUE</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>BLOOD LIPIDS</subject><subject>ENZYMIC ACTIVITY</subject><subject>FAMILIA</subject><subject>FAMILIAL INCIDENCE</subject><subject>FAMILIES</subject><subject>FAMILLE</subject><subject>Fatty Acids - physiology</subject><subject>Female</subject><subject>FOIE</subject><subject>Heparin - administration & dosage</subject><subject>Heparin - pharmacology</subject><subject>HIGADO</subject><subject>Humans</subject><subject>HYPERLIPEMIA</subject><subject>Hyperlipidemia, Familial Combined - blood</subject><subject>Hyperlipidemia, Familial Combined - drug therapy</subject><subject>Hyperlipidemia, Familial Combined - metabolism</subject><subject>Hypolipidemic Agents - therapeutic use</subject><subject>Injections, Intravenous</subject><subject>LIPAEMIA</subject><subject>Lipase - drug effects</subject><subject>Lipase - metabolism</subject><subject>LIPEMIA</subject><subject>LIPEMIE</subject><subject>LIPOLISIS</subject><subject>LIPOLYSE</subject><subject>LIPOLYSIS</subject><subject>Lipolysis - physiology</subject><subject>LIPOPROTEIN LIPASE</subject><subject>Lipoprotein(a) - blood</subject><subject>LIPOPROTEINA LIPASA</subject><subject>LIPOPROTEINAS</subject><subject>LIPOPROTEINE</subject><subject>LIPOPROTEINE LIPASE</subject><subject>LIPOPROTEINS</subject><subject>LIVER</subject><subject>Lovastatin - analogs & derivatives</subject><subject>Lovastatin - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>METABOLIC DISORDERS</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Simvastatin</subject><subject>Time Factors</subject><subject>TRASTORNOS METABOLICOS</subject><subject>TRIACILGLICEROL LIPASA</subject><subject>TRIACYLGLYCEROL LIPASE</subject><subject>triacylglycerol-rich lipoproteins</subject><subject>TROUBLE DU METABOLISME</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhSMEKkPhBRBIXiDULgJ2YifxBglV_FUjsYCureufdG5J7MH2FM3D8K54yDBLVpZ8vnt8fU5VvWD0DaOse0tp09WUS3Eh20tJGy7q6wfViom2qYeO0ofV6oQ8rp6kdEcp7fuhO6vOBsGoaNiq-r3GbdjGkB36C7gk2wnSDMQEb5zPETIGnwikFAxCdpb8wrwhUxma9hkNAZPxHjO6RNATh7ebTH6gt9HZtLAjzDghTMVz1uiLxWa_dbFYoHUzAgFviQ9xDv-uDEk7fedMTk-rRyNMyT07nufVzccP368-1-uvn75cvV_Xpm1orkfbSjFqPfRMlC9yqbWkQ0M7ZlvDHBfQgdaGy9YBGM615IIJa7VrjWxt155XrxffksTPnUtZzZiMmybwLuyS6kVf7BpZQL6AJoaUohvVNuIMca8YVYdW1CFydYhcyVb9bUVdl7GXR_-dnp09DR1rKPqrow7JwDRG8AbTCeOD6MvjBXu-YCMEBbexIDffJG8oa_oivltEV4K6RxdVMuhKjRZjyVLZgP9f8g_X2rXK</recordid><startdate>199306</startdate><enddate>199306</enddate><creator>Cabezas, Manuel Castro</creator><creator>de Bruin, Tjerk W.A.</creator><creator>Van Linde-Sibenius Trip, Margreet</creator><creator>Kock, Luciënne A.W.</creator><creator>Jansen, Hans</creator><creator>Erkelens, D.Willem</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199306</creationdate><title>Lipoprotein(a) plasma concentrations associated with lipolytic activities in eight kindreds with familial combined hyperlipidemia and normolipidemic subjects</title><author>Cabezas, Manuel Castro ; de Bruin, Tjerk W.A. ; Van Linde-Sibenius Trip, Margreet ; Kock, Luciënne A.W. ; Jansen, Hans ; Erkelens, D.Willem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-fd395fbb871500749bb9082061d3c1e45a6abbc493eaac44b94515ddbe3c93d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>ACTIVIDAD ENZIMATICA</topic><topic>ACTIVITE ENZYMATIQUE</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>BLOOD LIPIDS</topic><topic>ENZYMIC ACTIVITY</topic><topic>FAMILIA</topic><topic>FAMILIAL INCIDENCE</topic><topic>FAMILIES</topic><topic>FAMILLE</topic><topic>Fatty Acids - physiology</topic><topic>Female</topic><topic>FOIE</topic><topic>Heparin - administration & dosage</topic><topic>Heparin - pharmacology</topic><topic>HIGADO</topic><topic>Humans</topic><topic>HYPERLIPEMIA</topic><topic>Hyperlipidemia, Familial Combined - blood</topic><topic>Hyperlipidemia, Familial Combined - drug therapy</topic><topic>Hyperlipidemia, Familial Combined - metabolism</topic><topic>Hypolipidemic Agents - therapeutic use</topic><topic>Injections, Intravenous</topic><topic>LIPAEMIA</topic><topic>Lipase - drug effects</topic><topic>Lipase - metabolism</topic><topic>LIPEMIA</topic><topic>LIPEMIE</topic><topic>LIPOLISIS</topic><topic>LIPOLYSE</topic><topic>LIPOLYSIS</topic><topic>Lipolysis - physiology</topic><topic>LIPOPROTEIN LIPASE</topic><topic>Lipoprotein(a) - blood</topic><topic>LIPOPROTEINA LIPASA</topic><topic>LIPOPROTEINAS</topic><topic>LIPOPROTEINE</topic><topic>LIPOPROTEINE LIPASE</topic><topic>LIPOPROTEINS</topic><topic>LIVER</topic><topic>Lovastatin - analogs & derivatives</topic><topic>Lovastatin - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>METABOLIC DISORDERS</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Simvastatin</topic><topic>Time Factors</topic><topic>TRASTORNOS METABOLICOS</topic><topic>TRIACILGLICEROL LIPASA</topic><topic>TRIACYLGLYCEROL LIPASE</topic><topic>triacylglycerol-rich lipoproteins</topic><topic>TROUBLE DU METABOLISME</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cabezas, Manuel Castro</creatorcontrib><creatorcontrib>de Bruin, Tjerk W.A.</creatorcontrib><creatorcontrib>Van Linde-Sibenius Trip, Margreet</creatorcontrib><creatorcontrib>Kock, Luciënne A.W.</creatorcontrib><creatorcontrib>Jansen, Hans</creatorcontrib><creatorcontrib>Erkelens, D.Willem</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cabezas, Manuel Castro</au><au>de Bruin, Tjerk W.A.</au><au>Van Linde-Sibenius Trip, Margreet</au><au>Kock, Luciënne A.W.</au><au>Jansen, Hans</au><au>Erkelens, D.Willem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipoprotein(a) plasma concentrations associated with lipolytic activities in eight kindreds with familial combined hyperlipidemia and normolipidemic subjects</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>1993-06</date><risdate>1993</risdate><volume>42</volume><issue>6</issue><spage>756</spage><epage>761</epage><pages>756-761</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>The relationship between lipoprotein(a) [Lp(a)] and metabolism of triglyceride-rich lipoproteins (TRL) was studied in 58 untreated patients with familial combined hyperlipidemia (FCH) from eight different kindreds, 17 spouse controls, and 17 unrelated controls. Lp(a) plasma concentrations were not significantly different between FCH subjects (343 ± 61 mg/L, mean ± SEM) and controls (249 ± 52 mg/L). In FCH, log-transformed Lp(a) levels correlated positively with postheparin lipoprotein lipase ([LPL]
r = .61,
P = .0002) and hepatic lipase ([HL]
r = .46,
P = .008) activities and total plasma cholesterol level (
r = .30,
P = .03). In controls, Lp(a) correlated with LPL (
r = .50,
P = .04) and total plasma cholesterol level (
r = .51,
P = .003). In eight FCH patients, treatment with the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor simvastatin resulted in significantly increased mean LPL activities and plasma Lp(a) concentrations. In three of these FCH patients, repeated measurements during 1 year demonstrated that changes in Lp(a) concentrations were paralleled by similar changes in LPL activity, but not HL activity. The observed correlation between postheparin plasma lipolytic activities and Lp(a) plasma concentrations suggests a connection between the metabolism of TRL and Lp(a).</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8510521</pmid><doi>10.1016/0026-0495(93)90245-J</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0026-0495 |
| ispartof | Metabolism, clinical and experimental, 1993-06, Vol.42 (6), p.756-761 |
| issn | 0026-0495 1532-8600 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75782029 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | ACTIVIDAD ENZIMATICA ACTIVITE ENZYMATIQUE Adult Aged Aged, 80 and over Biological and medical sciences BLOOD LIPIDS ENZYMIC ACTIVITY FAMILIA FAMILIAL INCIDENCE FAMILIES FAMILLE Fatty Acids - physiology Female FOIE Heparin - administration & dosage Heparin - pharmacology HIGADO Humans HYPERLIPEMIA Hyperlipidemia, Familial Combined - blood Hyperlipidemia, Familial Combined - drug therapy Hyperlipidemia, Familial Combined - metabolism Hypolipidemic Agents - therapeutic use Injections, Intravenous LIPAEMIA Lipase - drug effects Lipase - metabolism LIPEMIA LIPEMIE LIPOLISIS LIPOLYSE LIPOLYSIS Lipolysis - physiology LIPOPROTEIN LIPASE Lipoprotein(a) - blood LIPOPROTEINA LIPASA LIPOPROTEINAS LIPOPROTEINE LIPOPROTEINE LIPASE LIPOPROTEINS LIVER Lovastatin - analogs & derivatives Lovastatin - therapeutic use Male Medical sciences Metabolic diseases METABOLIC DISORDERS Middle Aged Obesity Simvastatin Time Factors TRASTORNOS METABOLICOS TRIACILGLICEROL LIPASA TRIACYLGLYCEROL LIPASE triacylglycerol-rich lipoproteins TROUBLE DU METABOLISME |
| title | Lipoprotein(a) plasma concentrations associated with lipolytic activities in eight kindreds with familial combined hyperlipidemia and normolipidemic subjects |
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