Epidural clonidine depresses sympathetic nerve activity in humans by a supraspinal mechanism

Epidural administration of the alpha 2-adrenergic agonist clonidine induces hypotension. Animal experiments have indicated a possible spinal mechanism through activation of alpha 2-adrenergic receptors on sympathetic preganglionic neurons, resulting in a decrease of efferent sympathetic activity. Ho...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 1993-06, Vol.78 (6), p.1021-1027
Hauptverfasser:	KIRNÖ, K, LUNDIN, S, ELAM, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - administration & dosage Adrenergic alpha-Agonists - blood Adrenergic alpha-Agonists - pharmacology Adult Biological and medical sciences Clonidine - administration & dosage Clonidine - blood Clonidine - pharmacology Depression, Chemical Humans Hypnotics. Sedatives Injections, Epidural Injections, Intramuscular Medical sciences Middle Aged Muscles - innervation Neuropharmacology Peroneal Nerve - physiology Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopharmacology Skin - innervation Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiology
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